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Thymosin beta 4, X-linked

thymosin beta 4, Tbeta4
This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: beta-4, Actin, CAN, ACID, HAD
Papers using thymosin beta 4 antibodies
Thymosin beta 4 is involved in stabilin-2-mediated apoptotic cell engulfment.
Sham Mai Har, In PLoS ONE, 2007
... Tissue sections were incubated (30 min at room temperature) with the monoclonal anti-thymosin beta 4 antibody (Bachem, Bubendorf, Switzerland) ...
Different hepatocytes express the cholesterol 7 alphe hydroxylase gene during its circadian modulation in vivo
Faa G. et al., In European Journal of Histochemistry : EJH, 1994
... for 60 min to block non-specific binding, followed by incubation (20 h, 4°C) with polyclonal anti-thymosin beta 4 antibody (Bachem-Peninsula Lab, San Carlos, CA, ...
Papers on thymosin beta 4
Plasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock.
Rivers et al., Boston, United States. In Biomarkers, Feb 2016
OBJECTIVE: To compare plasma levels of F-actin, G-actin and thymosin beta 4 (TB4) in humans with septic shock, noninfectious systemic inflammatory response syndrome (SIRS) and healthy controls.
MALDI-imaging reveals thymosin beta-4 as an independent prognostic marker for colorectal cancer.
Habermann et al., Lübeck, Germany. In Oncotarget, Jan 2016
Among these, m/z 4,977 was identified as thymosin beta 4 (Tβ-4).
A thymosin beta-4 is involved in production of hemocytes and immune defense of Hong Kong oyster, Crassostrea hongkongensis.
Yu et al., Guangzhou, China. In Dev Comp Immunol, Jan 2016
UNASSIGNED: Thymosin beta-4 (Tβ4) is a ubiquitous protein with multiple and diverse intracellular and extracellular functions in vertebrates.
Thymosin Beta-4 Suppresses Osteoclastic Differentiation and Inflammatory Responses in Human Periodontal Ligament Cells.
Kim et al., Ch'ŏnan, South Korea. In Plos One, Dec 2015
BACKGROUND: Recent reports suggest that thymosin beta-4 (Tβ4) is a key regulator for wound healing and anti-inflammation.
Expression of thymosin beta-4 in human periodontal ligament cells and mouse periodontal tissue and its role in osteoblastic/cementoblastic differentiation.
Kim et al., Ch'ŏnan, South Korea. In Differentiation, Jul 2015
A recent report showed that thymosin beta-4 (Tβ4) is expressed during the development of tooth germ, but its effect on osteoblastic/cementoblastic differentiation is a controversial topic.
Potential role of thymosin Beta 4 in liver fibrosis.
Jung et al., Pusan, South Korea. In Int J Mol Sci, 2014
Thymosin beta 4 (Tβ4), a major actin-sequestering protein, is known to be involved in various cellular responses.
Thymosin β4 and cardiac regeneration: are we missing a beat?
Chaudhry et al., New York City, United States. In Stem Cell Rev, 2013
Priming with thymosin beta 4, a peptide which has been suggested to be critical for cardiac development and to have cardio-protective properties, was recently shown to induce differentiation of EPDCs into cardiomyocytes in a small animal model of myocardial infarction.
Regulation of glycogen synthase kinase-3 by thymosin beta-4 is associated with gastric cancer cell migration.
Moon et al., Seoul, South Korea. In Int J Cancer, 2012
investigated whether GSK-3 activity is regulated by thymosin beta-4 (Tbeta4) and associated with Tbeta4-mediated migration in gastric cancer cells; expression of GSK-3alpha, beta-catenin and E-cadherin could be negatively regulated by Tbeta4 induced ERK phosphorylation; suggests that Tbeta4 could be a novel regulator to control Wnt signal pathway
Thymosin β4: a potential novel dry eye therapy.
Crockford et al., Detroit, United States. In Ann N Y Acad Sci, 2012
The purpose of this manuscript is to review the clinical entity of dry eye syndrome (DES) and to provide a scientific basis and rationale for the usage of thymosin beta 4 (Tβ4) as a novel therapy for DES.
Thymosin β4 promotes the migration of endothelial cells without intracellular Ca2+ elevation.
Cierniewski et al., Łódź, Poland. In Exp Cell Res, 2012
The Our data confirm the concept that externally added Tbeta4 must be internalized to induce intracellular mechanisms supporting endothelial cell migration.
Thymosin β4 protein therapy for cardiac repair.
Riley et al., London, United Kingdom. In Curr Pharm Des, 2011
Although, future regenerative approaches may likely involve a synergistic protein cocktail, this review will focus on the role of a promising candidate, thymosin beta 4 (Tβ4) in cardioprotection, neovascularization, tissue regeneration and inflammation - all essential components in cardiac repair.
Interleukin-18-mediated interferon-gamma secretion is regulated by thymosin beta 4 in human NK cells.
Cho et al., Seoul, South Korea. In Immunobiology, 2011
Tbeta4 is regulated by IL-18 and is involved in IL-18-enhanced IFN-gamma secretion in NK cells.
Increased levels of thymosin β4 in synovial fluid of patients with rheumatoid arthritis: association of thymosin β4 with other factors that are involved in inflammation and bone erosion in joints.
Kim et al., Seoul, South Korea. In Int J Rheum Dis, 2011
Thymosin beta4 Tbeta4 may play an important role in bone degradation and inflammation in RA but not OA.
Thymosin-β4 (Tβ4) blunts PDGF-dependent phosphorylation and binding of AKT to actin in hepatic stellate cells.
Rojkind et al., Washington, D.C., United States. In Am J Pathol, 2011
findings suggest that Tbeta4 by sequestering actin prevents binding of AKT, thus inhibiting its phosphorylation
Treatment of chronic nonhealing neurotrophic corneal epithelial defects with thymosin beta4.
Sosne et al., Detroit, United States. In Ann N Y Acad Sci, 2010
We describe the results of nine patients (ages 37-84) with chronic nonhealing neurotrophic corneal epithelial defects who were treated with thymosin beta 4 (Tbeta4) sterile eye drops for 28 or 49 days with a follow-up period of 30 days.
Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization.
Riley et al., London, United Kingdom. In Nature, 2007
Here we identify thymosin beta4 (Tbeta4) as essential for all aspects of coronary vessel development in mice, and demonstrate that Tbeta4 stimulates significant outgrowth from quiescent adult epicardial explants, restoring pluripotency and triggering differentiation of fibroblasts, smooth muscle cells and endothelial cells.
Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair.
Srivastava et al., Dallas, United States. In Nature, 2004
Here, we show that the G-actin sequestering peptide thymosin beta4 promotes myocardial and endothelial cell migration in the embryonic heart and retains this property in postnatal cardiomyocytes.
Actin binding proteins: regulation of cytoskeletal microfilaments.
Nosworthy et al., Sydney, Australia. In Physiol Rev, 2003
In this review we selected several ABPs (ADF/cofilin, profilin, gelsolin, thymosin beta4, DNase I, CapZ, tropomodulin, and Arp2/3) that regulate actin-driven assembly, i.e., movement that is independent of motor proteins.
Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids.
Stevenson et al., Glasgow, United Kingdom. In Nat Med, 1999
Here we show that thymosin beta4 sulfoxide is generated by monocytes in the presence of glucocorticoids and acts as a signal to inhibit an inflammatory response.
How profilin promotes actin filament assembly in the presence of thymosin beta 4.
Carlier et al., Gif-sur-Yvette, France. In Cell, 1994
As a consequence, in the presence of thymosin beta 4 (T beta 4), low amounts of profilin promote extensive actin assembly off of the pool of actin-T beta 4 complex.
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