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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


Thl, trichohyalin, THH
Trichohyalin confers mechanical strength to the hair follicle inner root sheath and to other toughened epithelial tissues, such as the hard palate and filiform ridges of the tongue, by forming multiple complex crosslinks with itself and with other structural proteins (Steinert et al., 2003 [PubMed 12853460]).[supplied by OMIM, Dec 2009] (from NCBI)
Top mentioned proteins: TH2, IFN-gamma, IL-4, HAIR, CAN
Papers on Thl
Techno-functional properties and in vitro bile acid-binding capacities of tamarillo (Solanum betaceum Cav.) hydrocolloids.
Muhammad et al., Kuala Selangor, Malaysia. In Food Chem, May 2016
The seed mucilage hydrocolloids that were extracted, using either 1% citric acid (THC) or water (THW), had a good foaming capacity (32-36%), whereas the pulp hydrocolloids that were extracted, using 72% ethanol (THE) or 20mM HEPES buffer (THH), had no foaming capacity.
A Hyalinized Trichilemmoma of the Eyelid in a Teenager.
Mihm et al., Boston, United States. In Ophthal Plast Reconstr Surg, Jan 2016
On excision, the dermal nodule was contiguous with the epidermis, displayed trichohyalin-like bodies in an expanded outer root sheath, and was composed chiefly of small cellular clusters separated by a prominent network of periodic acid Schiff -positive hyaline bands of basement membrane material.
Cutaneous Epithelial Lesions Induced by N-Methyl-N-nitrosourea in Male Sprague-Dawley Rats: A Possible Animal Model for Human Keratoacanthoma.
Kurokawa et al., Hirakata, Japan. In Anticancer Res, Jan 2016
Keratoacanthomas were crater-shaped tumors with thick infoldings of epithelium containing keratohyalin granules (epidermal lip) that abruptly changed to epithelium containing trichohyalin granules.
Ethyl pyruvate ameliorates experimental colitis in mice by inhibiting the HMGB1-Th17 and Th1/Tc1 responses.
Zhou et al., Dongguan, China. In Int Immunopharmacol, Dec 2015
HMGB1 has been implicated in several autoimmune diseases by inducing Thl and Thl7 cells activation.
Promotion of Cancer Stem-Like Cell Properties in Hepatitis C Virus-Infected Hepatocytes.
Ray et al., Saint Louis, United States. In J Virol, Dec 2015
We also found c-Kit is highly expressed in transformed human hepatocytes (THH) infected in vitro with cell culture-grown HCV genotype 2a.
Molecular Heterogeneity and Response to Neoadjuvant Human Epidermal Growth Factor Receptor 2 Targeting in CALGB 40601, a Randomized Phase III Trial of Paclitaxel Plus Trastuzumab With or Without Lapatinib.
Hudis et al., Durham, United States. In J Clin Oncol, Dec 2015
PATIENTS AND METHODS: Patients with stage II to III HER2-positive breast cancer underwent tumor biopsy followed by random assignment to paclitaxel plus trastuzumab alone (TH) or with the addition of lapatinib (THL) for 16 weeks before surgery.
Spiny Papules in an Immunosuppressed Child.
Prok et al., Aurora, United States. In Pediatr Dermatol, Nov 2015
Histologic evaluation revealed hypertrophic bulbs, an expanded inner root sheath, and numerous brightly eosinophilic trichohyalin granules.
[Heparin-treated dendritic cells promote Th0 to Th1 differentiation via the Toll-like receptor 3 in peripheral blood monocytes of patients with chronic hepatitis B].
Gao et al., Qingdao, China. In Zhonghua Gan Zang Bing Za Zhi, Oct 2015
less than 0.01),as was the capability of Thl to generate IFNg (t =20.83,Pless than 0.01).
Vaccination with ubiquitin-hepatitis B core antigen-cytoplasmic transduction peptide enhances the hepatitis B virus-specific cytotoxic T-lymphocyte immune response and inhibits hepatitis B virus replication in transgenic mice.
Tang et al., Shanghai, China. In Mol Med Report, Sep 2015
Chronic hepatitis B virus (HBV) infection is characterized by functionally impaired type 1 T-helper cell (Thl) immunity and poor HBV‑specific T‑cell responses.
The proteomics of wool fibre morphogenesis.
Scobie et al., Christchurch, New Zealand. In J Struct Biol, Sep 2015
The first epithelial KAP, trichohyalin, was detected in the bulb portion and the first cortical KAP, KAP11.1 was found in the elongation portion.
Kozlova et al., In Ross Fiziol Zh Im I M Sechenova, Aug 2015
Growth factors modulate the functions of Thl, Th2, Treg, Thl7, Th9.
Diagnosis of 'double hit' diffuse large B-cell lymphoma and B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma: when and how, FISH versus IHC.
Swerdlow, Pittsburgh, United States. In Hematology Am Soc Hematol Educ Program, 2015
Large B-cell lymphomas with MYC plus BCL2 and/or BCL6 rearrangements, so-called 'double hit' (DHL) or 'triple hit' (THL) lymphomas, are one such group of cases often recognized using cytogenetic FISH studies.
The biology of hair diversity.
Tobin et al., Bradford, United Kingdom. In Int J Cosmet Sci, 2013
The recent discovery that the gene for trichohyalin contributes to hair shape comes as no surprise to the hair biologists who have believed for 100 years that hair shape is linked to the structure and function of the inner root sheath.
Double-hit and triple-hit lymphomas arising from follicular lymphoma following acquisition of MYC: report of two cases and literature review.
Zhang et al., Tianjin, China. In Int J Clin Exp Pathol, 2012
Double-hit or triple-hit B-cell lymphomas (DHL and THL) are rare subtype lymphomas usually associated with poor prognosis.
Perspectives on hair evolution based on some comparative studies on vertebrate cornification.
Alibardi, Bologna, Italy. In J Exp Zool B Mol Dev Evol, 2012
In a following stage, involucrin, trichohyalin, and keratins were produced in the central cells of the gland and formed a solid medulla surrounded by keratinocytes of the inner root sheath.
Identification of the C-terminal tail domain of AHF/trichohyalin as the critical site for modulation of the keratin filamentous meshwork in the keratinocyte.
Hirai et al., Sanda, Japan. In J Dermatol Sci, 2012
In anagenic hair follicles AHF latches onto the keratin bundles by its C-terminus and rearranges the keratin meshwork by intrinsic cohesive activity for the granule formation.
Trichohyalin is a potential major autoantigen in human alopecia areata.
Tobin et al., Bradford, United Kingdom. In J Proteome Res, 2010
Data suggest that an immune response to trichohyalin and K16 may have a role in the pathogenesis of the enigmatic disorder.
Common variants in the trichohyalin gene are associated with straight hair in Europeans.
Martin et al., Brisbane, Australia. In Am J Hum Genet, 2009
Common variants in the TCHH gene are associated with straight hair in Europeans.
Molecular elements of the regulatory control of keratin filament modulator AHF/trichohyalin in the hair follicle.
Hirai et al., Kyoto, Japan. In Exp Dermatol, 2009
BMP-4 signalling activates AHF/THH transcription in hair follicles.
Trichohyalin mechanically strengthens the hair follicle: multiple cross-bridging roles in the inner root shealth.
Marekov et al., Bethesda, United States. In J Biol Chem, 2003
Trichohyalin is a multi-functional cross-bridging protein that functions in the inner root sheath and other specialized epithelial tissues
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