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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Heart and neural crest derivatives expressed transcript 2

TH2, Hand2, dHAND
Top mentioned proteins: IL-4, CAN, IL-10, CD4, IL-13
Papers using TH2 antibodies
Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2.
Nurminsky Dmitry I., In PLoS ONE, 2002
... (Santacruz, sc-1615), Nucleolin (Santacruz, sc13057), Lamin A (Santacruz, sc-20680), MEF2C (Abcam, ab65252), HDAC4 (Cell Signaling, #2072), HAND2 (Abcam, ab56590), Tropomyosin C (Santacruz, sc73225), ...
Papers on TH2
Dimethyl fumarate treatment alters circulating T helper cell subsets in multiple sclerosis.
Klotz et al., Münster, Germany. In Neurol Neuroimmunol Neuroinflamm, Feb 2016
METHODS: Peripheral lymphocyte subsets, including CD4(+) and CD8(+) memory cells and T helper (TH) cells TH1, TH2, TH17, and peripheral regulatory T cell (pTreg) subpopulations were analyzed before and 6 months after onset of DMF treatment.
T-cell-intrinsic Tif1α/Trim24 regulates IL-1R expression on TH2 cells and TH2 cell-mediated airway allergy.
Wilson et al., London, United Kingdom. In Proc Natl Acad Sci U S A, Feb 2016
Although a variety of immune cells contribute to allergy, cytokine-secreting αβ(+)CD4(+) T-helper 2 (TH2) cells orchestrate the type-2-driven immune response in a large proportion of atopic asthmatics.
Pro- and Anti-Inflammatory Role of ChemR23 Signaling in Pollutant-Induced Inflammatory Lung Responses.
Joos et al., Gent, Belgium. In J Immunol, Feb 2016
We previously demonstrated that exposure to DEP was associated with increased recruitment and maturation of monocytes and conventional dendritic cells (DCs), resulting in TH2 polarization.
Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease.
Chan et al., San Francisco, United States. In Cell, Feb 2016
Dennd1b(-/-) TH2, but not other TH cells, exhibit delayed receptor-induced T cell receptor (TCR) downmodulation, enhanced TCR signaling, and increased production of effector cytokines.
Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit.
Locksley et al., San Francisco, United States. In Nature, Feb 2016
This response, known as 'weep and sweep', requires interleukin (IL)-13 production by tissue-resident group 2 innate lymphoid cells (ILC2s) and recruited type 2 helper T cells (TH2 cells).
Cord blood monocyte-derived inflammatory cytokines suppress IL-2 and induce nonclassic "TH2-type" immunity associated with development of food allergy.
BIS Investigator Group et al., Australia. In Sci Transl Med, Feb 2016
Infants who develop food allergy display a proinflammatory immune profile in cord blood, but how this is related to interleukin-4 (IL-4)/T helper 2 (TH2)-type immunity characteristic of allergy is unknown.
Motor Behavior Mediated by Continuously Generated Dopaminergic Neurons in the Zebrafish Hypothalamus Recovers after Cell Ablation.
Dorsky et al., Salt Lake City, United States. In Curr Biol, Feb 2016
Here, we have identified a progenitor population in the zebrafish hypothalamus that continuously generates neurons that express tyrosine hydroxylase 2 (th2).
Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses.
Koyasu et al., Yokohama, Japan. In Nat Immunol, Jan 2016
IFN-γ effectively suppressed the function of tissue-resident ILC2 cells but not that of inflammatory ILC2 cells, and IL-27 suppressed tissue-resident ILC2 cells but not tissue-resident TH2 cells during lung inflammation induced by Alternaria alternata.
Targeting key proximal drivers of type 2 inflammation in disease.
Yancopoulos et al., New York City, United States. In Nat Rev Drug Discov, Jan 2016
Systemic type 2 inflammation encompassing T helper 2 (TH2)-type responses is emerging as a unifying feature of both classically defined allergic diseases, such as asthma, and a range of other inflammatory diseases.
Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses.
McKenzie et al., Columbia, United States. In Nat Immunol, Jan 2016
Rapid activation of memory CD4(+) T helper 2 (TH2) cells during allergic inflammation requires their recruitment into the affected tissue.
Drivers of chronic rhinosinusitis: Inflammation versus infection.
Hamilos, Boston, United States. In J Allergy Clin Immunol, Dec 2015
Conversely, certain innate factors, namely IL-25, IL-33, and thymic stromal lymphopoietin (TSLP), are elaborated by sinus epithelial cells in response to microbial stimulation or airway injury and promote local TH2 inflammation.
Current and future treatment options for adult chronic rhinosinusitis: Focus on nasal polyposis.
Gevaert et al., Gent, Belgium. In J Allergy Clin Immunol, Dec 2015
Several clinical phenotypes often leading to uncontrolled disease, including adult nasal polyposis, aspirin-exacerbated respiratory disease, and allergic fungal rhinosinusitis, are characterized by a common endotype: a TH2 bias is associated with a higher likelihood of comorbid asthma and recurrence after surgical treatment.
Effect of allergen-specific immunotherapy on CD4+ T cells.
Wambre, Seattle, United States. In Curr Opin Allergy Clin Immunol, Dec 2015
Recent studies have demonstrated that AIT may restore tolerance by transiently inducing interleukin (IL)-10 producing T cells followed by selective deletion of allergen-specific TH2 cell subset.
Prenatal Stress, Prematurity, and Asthma.
Celedón et al., Pittsburgh, United States. In Obstet Gynecol Surv, Dec 2015
Moreover, maternal stress can alter fetal cytokine balance, favoring TH2 (allergic) immune responses characteristic of atopic asthma: interleukin 6 (IL-6), which has been associated with premature labor, can promote TH2 responses by stimulating production of IL-4 and IL-13.
Along the Axis between Type 1 and Type 2 Immunity; Principles Conserved in Evolution from Fish to Mammals.
Dijkstra et al., Greifswald, Germany. In Biology (basel), 2014
A phenomenon already discovered more than 25 years ago is the possibility of naïve helper T cells to polarize into TH1 or TH2 populations.
Identification and characterization of the zebrafish pharyngeal arch-specific enhancer for the basic helix-loop-helix transcription factor Hand2.
Clouthier et al., Aurora, United States. In Dev Biol, 2012
Data indicate that mouse and zebrafish hand2 enhancers both drive transgene expression in the pharyngeal arches.
Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2.
Ruest et al., Dallas, United States. In Dev Dyn, 2012
Twist1, along with Hand2, is essential for the proximodistal patterning and development of the mandible and ossification.
Targeted deletion of Hand2 in enteric neural precursor cells affects its functions in neurogenesis, neurotransmitter specification and gangliogenesis, causing functional aganglionosis.
Howard et al., Toledo, United States. In Development, 2011
Results suggest that Hand2 is essential for neurogenesis, neurotransmitter specification and neural network patterning in the developing enteric nervous system.
Expression level of Hand2 affects specification of enteric neurons and gastrointestinal function in mice.
Gershon et al., Paris, France. In Gastroenterology, 2011
We now show that enteric neurogenesis is a quantitative function of Hand2 expression in mice.
Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis.
Clouthier et al., Aurora, United States. In Development, 2011
Hand2 plays key role in lower jaw patterning in part by establishing negative-feedback loop in which Hand2 represses Dlx5 and Dlx6 expression in distal arch ectomesenchyme following Dlx5- and Dlx6-mediated induction of Hand2 expression in the same region
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