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TGFB-induced factor homeobox 2-like, X-linked

This gene encodes a member of the TALE/TGIF homeobox family of transcription factors. Testis-specific expression suggests that this gene may play a role in spermatogenesis. A homolog of this gene lies within the male specific region of chromosome Y, in a block of sequence that is thought to be the result of a large X-to-Y transposition. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: TGIF2, TGIF, TGIFLY, MEN, HAD
Papers on TGIFLX
Induction of Apoptosis and Growth Suppression by Homeobox Gene TGIFLX in Prostate Cancer Cell Line Lncap.
Shirkoohi et al., Tehrān, Iran. In Iran J Public Health, 2013
BACKGROUND: TGIFLX, a Homoproteins cluster member located on the X chromosome, has a critical role in male reproduction and prostate development.
Differential expression of human homeodomain TGIFLX in brain tumor cell lines.
Heidari et al., Tehrān, Iran. In Acta Med Iran, 2012
Our previous study showed implications of TGIFLX in prostate cancer and azoospermia, although the molecular mechanism by which TGIFLX acts is unknown.
Copy number variants on the X chromosome in women with primary ovarian insufficiency.
Dutch Primary Ovarian Insufficiency Consortium et al., Utrecht, Netherlands. In Fertil Steril, 2011
Moreover, CNVs in two genes on the Xq21.3 locus (i.e., PCDH11X and TGIF2LX) were statistically significantly associated with the POI phenotype.
Differential roles of TGIF family genes in mammalian reproduction.
Pask et al., Melbourne, Australia. In Bmc Dev Biol, 2010
BACKGROUND: TG-interacting factors (TGIFs) belong to a family of TALE-homeodomain proteins including TGIF1, TGIF2 and TGIFLX/Y in human.
Association of TGIFLX/Y mRNA expression with prostate cancer.
Heidari et al., Tehrān, Iran. In Med Oncol, 2008
most prostate tumors (73.5%) express at least one of these genes (TGIFLX and TGIFLY), although different patterns of mRNA expression were observed. These results suggest an association of TGIFLX/Y expression with the progression of prostate cancer.
Association of TGIFLX/Y mRNA expression with azoospermia in infertile men.
Heidari et al., Tehrān, Iran. In Mol Reprod Dev, 2008
Association of TGIFLX/Y mRNA expression with azoospermia in infertile men.(
Transgenic analyses of TGIF family proteins in Drosophila imply their role in cell growth.
Wang et al., Beijing, China. In J Genet Genomics, 2008
TG-interacting factors (TGIFs) belong to a family of TALE-homeodomain proteins including TGIF, TGIF2, and TGIF2LX/Y (TGIF2 like on X or Y chromosome) in human.
Rapid evolution of mammalian X-linked testis-expressed homeobox genes.
Zhang et al., Ann Arbor, United States. In Genetics, 2004
TGIFLX is an X-linked homeobox gene that originated by retroposition of the autosomal gene TGIF2, most likely in a common ancestor of rodents and primates.
The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon.
Affara et al., Cambridge, United Kingdom. In Mamm Genome, 2002
This paper reports the genomic structure, expression, and evolutionary conservation of a third (X-Y homologous) transcribed sequence, TGIFLX/Y (TGIF-like X/Y), mapping to this region.
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