gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

TGFB-induced factor homeobox 2

The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: TGIF, CAN, TGF-beta, ACID, miR
Papers on TGIF2
MicroRNA-34c targets TGFB-induced factor homeobox 2, represses cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma.
Liu et al., Jinan, China. In Oncol Lett, Nov 2015
transforming growth factor-β-induced factor homeobox 2 (TGIF2), a transcription factor repressing transforming growth factor-β (TGFβ) signaling, was observed to be upregulated and was identified as a target gene of miR-34c.
[Metabolism enzyme controls cancer stemness].
Ishii et al., In Nihon Rinsho, May 2015
TGIF2 was identified which interacted with PKM2 in nucleus in response to EMT induction, which was considered to have a key role in controlling EMT induction.
TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia.
Porse et al., Copenhagen, Denmark. In Leukemia, May 2015
TGIF1/TGIF2 are relatively uncharacterized TALE transcription factors, which, in contrast to the remaining family, have been shown to act as transcriptional repressors.
Role of TG-interacting factor (Tgif) in lipid metabolism.
Parini et al., Huddinge, Sweden. In Biochim Biophys Acta, 2015
As these proteins can interact with the ligand binding domain of retinoid X receptor α, a common heterodimeric partner of several nuclear receptors [e.g., liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs)], Tgif1 and Tgif2 might repress other transcriptional pathways activated by lipids.
MicroRNA-34a inhibits tumor invasion and metastasis in gastric cancer by targeting Tgif2.
Lin et al., Chengdu, China. In Int J Clin Exp Pathol, 2014
First, real-time polymerase chain reaction (PCR) and western blot analysis were used to analyze the expression of miR-34a and Tgif2 in gastric cancer tissues and the adjacent normal tissues.
Role of 5'TG3'-interacting factors (TGIFs) in Vorinostat (HDAC inhibitor)-mediated Corneal Fibrosis Inhibition.
Mohan et al., Morocco. In Mol Vis, 2014
RNA isolation, cDNA preparation, and PCR were performed to detect the presence of TGIF1 and TGIF2 transcripts.
Down-Regulation of miR-148a Promotes Metastasis by DNA Methylation and is Associated with Prognosis of Skin Cancer by Targeting TGIF2.
Yang et al., Beijing, China. In Med Sci Monit, 2014
The purpose of this study was to investigate the methylation status of miR-148a and its effects on the metastasis and prognosis of skin cancer, as well as the interaction with TGIF2 gene.
Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.
Ishii et al., Ōsaka, Japan. In Proc Natl Acad Sci U S A, 2014
Immunoprecipitation and LC-electrospray ionized TOF MS analyses revealed that EMT stimulation causes direct interaction of PKM2 in the nucleus with TGF-β-induced factor homeobox 2 (TGIF2), a transcriptional cofactor repressor of TGF-β signaling.
miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.
Wan et al., Dallas, United States. In Nature, 2014
Mechanistically, we identify transforming growth factor-β-induced factor 2 (Tgif2) as an essential direct miR-34a target that is pro-osteoclastogenic. Tgif2 deletion reduces bone resorption and abolishes miR-34a regulation.
Identification of FoxR2 as an oncogene in medulloblastoma.
Watanabe et al., Tokyo, Japan. In Cancer Res, 2014
Tgif2 and Alx4, 2 new putative oncogenes identified in the screen, are strongly expressed in the SHH subtype of human medulloblastoma.
A multi-resource data integration approach: identification of candidate genes regulating cell proliferation during neocortical development.
Nowakowski et al., Tallahassee, United States. In Front Neurosci, 2013
We used a mouse in situ hybridization dataset (The Allen Institute for Brain Science) to identify 13 genes (Cdon, Celsr1, Dbi, E2f5, Eomes, Hmgn2, Neurog2, Notch1, Pcnt, Sox3, Ssrp1, Tead2, Tgif2) with high correlation of expression in the proliferating cells of the VZ of the neocortex at early stages of development (E15.5).
Whole genome sequence analysis suggests intratumoral heterogeneity in dissemination of breast cancer to lymph nodes.
Shaw et al., Leicester, United Kingdom. In Plos One, 2013
Novel mutations unique to the node included those found in two CIN25 targets, TGIF2 and CCNB2, which are related to transcription cyclin activity and chromosomal stability, respectively, and a unique frameshift in PDS5B, which is required for accurate sister chromatid segregation during cell division.
Expression of microRNA-30c and its target genes in human osteoblastic cells by nano-bioglass ceramic-treatment.
Selvamurugan et al., India. In Int J Biol Macromol, 2013
TGIF2 and HDAC4 were found to be its putative target genes and their expression was down regulated by nBGC-treatment in MG63 cells.
Identification of a neuronal transcription factor network involved in medulloblastoma development.
Jackson et al., Newcastle upon Tyne, United Kingdom. In Acta Neuropathol Commun, 2012
Strikingly, these candidate genes were enriched for transcription factors (p=2x10-5), the majority of which (6/7; Crebbp, Myt1L, Nfia, Nfib, Tead1 and Tgif2) were linked within a single regulatory network enriched for genes associated with a differentiated neuronal phenotype.
Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation.
Wotton et al., Charlottesville, United States. In Development, 2010
Data show that loss-of-function mutations in both Tgif1 and Tgif2 result in a failure of gastrulation.
The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm.
Brivanlou et al., New York City, United States. In Development, 2008
TGIF2 is the molecular link between dorsoventral patterning of the endoderm and pancreatic specification.
Functional analysis of mutations in TGIF associated with holoprosencephaly.
Muenke et al., Bethesda, United States. In Mol Genet Metab, 2007
In contrast, no potentially pathogenic sequence alterations were detected in the related gene TGIF2.
The Tgif2 gene contains a retained intron within the coding sequence.
Wotton et al., Charlottesville, United States. In Bmc Mol Biol, 2005
The Tgif2 gene contains a retained intron, within the second coding exon. One splice variant encodes the full length 237 amino acid Tgif2, whereas the shorter form results in the removal of 39 codons from the centre of the coding region.
Expression pattern of TG-interacting factor 2 during mouse development.
Chen et al., Shanghai, China. In Gene Expr Patterns, 2005
TGIF2 has a wide but well controlled expression pattern during mouse development.
share on facebooktweetadd +1mail to friends