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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Transforming growth factor, alpha

This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: Epidermal Growth Factor, EGFR, CAN, HAD, TGF-beta
Papers on TGF-alpha
The body mass index (BMI) is significantly correlated with levels of cytokines and chemokines in cerebrospinal fluid.
Thulin et al., Uppsala, Sweden. In Cytokine, Dec 2015
In contrast, at a false discovery rate of 10%, 19 markers were significantly associated with BMI (in decreasing significance: FGF-5, ADA, Beta-NGF, CD40, IL-10RB, CCL19, TGF-alpha, SIRT2, TWEAK, SCF, CSF-1, 4E-BP1, DNER, LIF-R, STAMPB, CXCL10, CXCL6, VEGF-A and CX3CL1).
Pretreatment levels of the serum biomarkers CEA, CYFRA 21-1, SCC and the soluble EGFR and its ligands EGF, TGF-alpha, HB-EGF in the prediction of outcome in erlotinib treated non-small-cell lung cancer patients.
Páez de la Cadena et al., Vigo, Spain. In Springerplus, 2014
The aim of this study has been to investigate the potential of serum biomarkers used in clinical practice (CEA, CYFRA 21-1, SCC) together with the serum epidermal growth factor receptor (EGFR) and its associated ligands (EGF, TGF-α, HB-EGF) as outcome predictors of non-small cell lung cancer (NSCLC) patients treated with the TKI erlotinib.
[Prognostic value of clinical and morphological characteristics in radiation and combined treatment for tongue cancer].
Plavnik et al., In Vopr Onkol, 2014
It is now possible to identify several key factors that determine biological characteristics of squamous cell cancer of the head and neck: genes p53, p16, cyclin D1, P13-K/Akt connected with metastasis proteins (proteases, proteins mesenchymal cells, cell adhesion molecules chemokines), angiogenesis factors (VEGF, PDGF, FGF, TGF-alpha and TGF-beta), IL-8; epidermal growth factor receptors.
Possible implications of TGF-alpha in oesophageal dysmotility in systemic sclerosis.
Perkovic et al., Dubrovnik, Croatia. In Clin Exp Rheumatol, 2014
OBJECTIVES: Hypoxia is a characteristic feature of systemic sclerosis (SSc).Transforming growth factor alpha (TGF-α) has an important role in excessive inflammation under hypoxic conditions.
Transforming growth factor alpha controls the transition from hypertrophic cartilage to bone during endochondral bone growth.
Beier et al., London, Canada. In Bone, 2012
TGFalpha appears to be an important growth factor regulating the conversion of cartilage to bone during the process of endochondral ossification.
Transforming growth factor α immunoreactivity. A study in hepatocellular carcinoma and in non-neoplastic liver tissue.
Avancini-Alves et al., Rio de Janeiro, Brazil. In Ann Hepatol, 2012
Report TGF-alpha expression in hepatocellular carcinoma.
Transforming growth factor-α mRNA expression and its possible roles in mouse endometrial stromal cells.
Takahashi et al., Okayama, Japan. In Zoolog Sci, 2012
These results imply that TGFalpha stimulates proliferation of endometrial stromal cells through multiple mechanisms, including its regulation of Igfbp3 and Mmp3 transcription.
Genetic variation in the transforming growth factor-β-signaling pathway, lifestyle factors, and risk of colon or rectal cancer.
Caan et al., Salt Lake City, United States. In Dis Colon Rectum, 2012
Colon and rectal cancer risk increased with the number of at-risk genotypes within the transforming growth factor-beta-signaling pathway (OR 3.68, 95% CI 2.74,4.94 for colon cancer; OR 3.89, 95% CI 2.66,5.69 for rectal cancer).
ADAM-17/tumor necrosis factor-α-converting enzyme inhibits neurogenesis and promotes gliogenesis from neural stem cells.
Estrada et al., Madrid, Spain. In Stem Cells, 2011
ADAM-17 and TGF-alpha are strongly and locally upregulated following adult mice cortical damage.
Molecular mechanisms of liver regeneration and protection for treatment of liver dysfunction and diseases.
Ozaki et al., Sapporo, Japan. In J Hepatobiliary Pancreat Sci, 2011
Hepatocytes are "primed" mainly by Kupffer cells via cytokines (IL-6 and TNF-alpha) and then "proliferation" and "cell growth" of hepatocytes are induced by the stimulations of cytokines and growth factors (HGF and TGF-alpha).
Vitamin D inhibition of TACE and prevention of renal osteodystrophy and cardiovascular mortality.
Tokumoto et al., Saint Louis, United States. In J Steroid Biochem Mol Biol, 2010
1,25(OH)2D prevents/moderates not only the onset and progression of parathyroid TACE/TGFalpha-driven secondary hyperparathyroidism, but, more significantly, renal TACE/TGFalpha-driven fibrotic and inflammatory lesions to the renal parenchyma, and TACE/TNFalpha-driven systemic inflammation, which is known to aggravate renal and cardiovascular lesions and enhance the risk of vascular calcification and cardiovascular mortality.
Epithelial repair mechanisms in the lung.
Waters et al., Memphis, United States. In Am J Physiol Lung Cell Mol Physiol, 2010
Injury causes the release of factors that contribute to repair mechanisms including members of the epidermal growth factor and fibroblast growth factor families (TGF-alpha, KGF, HGF), chemokines (MCP-1), interleukins (IL-1beta, IL-2, IL-4, IL-13), and prostaglandins (PGE(2)), for example.
TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation.
Xu et al., Ann Arbor, United States. In Cell, 2010
Wavy hair phenotypes in mice result from naturally occurring loss-of-function mutations in the genes for TGF-alpha and EGFR.
Cutaneous vascular patterns in psoriasis.
Nasca et al., Catania, Italy. In Int J Dermatol, 2010
Investigational studies have shown that activated keratinocytes in lesional skin undergo an accelerated epidermal cell turnover and are a major source of pro-angiogenic cytokines, like as VEGF, ESAF, PDECGE/TP, TNF-alpha, TGF-alpha and PDGF, suggesting that the epidermis is capable of inducing vascular proliferation.
The antiproliferative effect of kefir cell-free fraction on HuT-102 malignant T lymphocytes.
Baydoun et al., Beirut, Lebanon. In Clin Lymphoma Myeloma, 2008
Kefir cell-free fraction caused the downregulation of TGF-alpha, which is a cytokine that induces the proliferation and replication of cells.
Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.
Schmid et al., München, Germany. In Cancer Cell, 2007
Concomitant expression of TGFalpha and Kras(G12D) accelerates the progression of mPanIN lesions to metastatic pancreatic cancer and leads to the development of cystic papillary lesions resembling human intraductal papillary mucinous neoplasms (IPMN).
The response of human epithelial cells to TNF involves an inducible autocrine cascade.
Sorger et al., Cambridge, United States. In Cell, 2006
By applying classifier-based regression to a cytokine-signaling compendium of approximately 8000 intracellular protein measurements, we demonstrate that cells respond to TNF both directly, via activated TNF receptor, and indirectly, via the sequential release of transforming growth factor-alpha (TGF-alpha), interleukin-1alpha (IL-1alpha), and IL-1 receptor antagonist (IL-1ra).
Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma.
Coffey et al., Nashville, United States. In J Clin Oncol, 2006
Serial serum samples were measured for amphiregulin and transforming growth factor-alpha (TGFalpha).
Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach.
Terzi et al., Paris, France. In Nat Med, 2005
Transforming growth factor-alpha (TGF-alpha) and its sheddase, TACE (also known as ADAM17), were induced by AngII treatment, TACE was redistributed to apical membranes and EGFR was phosphorylated.
Polyamines Regulate Growth Factor-Induced Protein Phosphorylation in MCF-7 Human Breast Cancer Cells.
Kim et al., In Cancer Res Treat, 2002
RESULTS: E2, TGF-alpha, and EGF enhanced the protein phosphorylation in very similar pattern.
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