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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Tripartite motif containing 39

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, CaM, HAD, V1a
Papers on TFP
Effects of Phospholipase A2 Inhibitors on Bilayer Lipid Membranes.
Belosludtsev et al., Moscow, Russia. In J Membr Biol, Feb 2016
It was established that trifluoroperazine (TFP) and, to a lesser extent, arachidonyl trifluoromethyl ketone (AACOCF3) and palmitoyl trifluoromethyl ketone (PACOCF3) were able to permeabilize artificial lipid membranes (BLM and liposomes).
Novel bispecific PSMA/GRPr targeting radioligands with optimized pharmacokinetics for improved PET imaging of prostate cancer.
Kopka et al., In Bioconjug Chem, Feb 2016
The two pharmacophores were coupled through Copper(I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC) to the bis(tetrafluorophenyl) (TFP) ester of the chelating agent HBED-CC chelator via amino acid-linkers made of positively charged His and (H) and negatively charged Glug acid (E): -(HE)n-, (n=0-3).
Calmodulin inhibition regulates morphological and functional changes related to the actin cytoskeleton in pure microglial cells.
Gulya et al., Szeged, Hungary. In Brain Res Bull, Jan 2016
The roles of calmodulin (CaM), a multifunctional intracellular calcium receptor protein, as concerns selected morphological and functional characteristics of pure microglial cells derived from mixed primary cultures from embryonal forebrains of rats, were investigated through use of the CaM antagonists calmidazolium (CALMID) and trifluoperazine (TFP).
Reversal of Pathological Features of Graves' Orbitopathy by Activation of Forkhead Transcription Factors, FOXOs.
Ludgate et al., Cardiff, United Kingdom. In J Clin Endocrinol Metab, Jan 2016
DESIGN/SETTING/PARTICIPANTS: Human orbital and sc primary PFs were treated with small interfering RNA/chemical inhibitor (AS1842856) of FOXOs or FOXO enhancer trifluoperazine hydrochloride (TFP; Food and Drug Administration approved drug), in serum-free medium for 24 hours, or TFP treatment in adipogenic medium for 15 days.
The interaction of salicylic acid and Ca(2+) alleviates aluminum toxicity in soybean (Glycine max L.).
Yang et al., Changchun, China. In Plant Physiol Biochem, Jan 2016
The Al-induced inhibition of root elongation was ameliorated by Ca(2+) and SA but aggravated by Ca(2+) channel inhibitor (VP), CaM antagonists (TFP), Ca(2+) chelator (EGTA), and SA biosynthesis inhibitor (PAC).
Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats.
Boyce et al., Thousand Oaks, United States. In Bone, Jan 2016
Animals were administered Scl-Ab 3 or 50mg/kg/wk or vehicle (VEH) for up to 26weeks (d183), followed by a treatment-free period (TFP).
Anion Channel Inhibitor NPPB-Inhibited Fluoride Accumulation in Tea Plant (Camellia sinensis) Is Related to the Regulation of Ca(2+), CaM and Depolarization of Plasma Membrane Potential.
Wan et al., Hefei, China. In Int J Mol Sci, Dec 2015
Besides, pretreatment with the Ca(2+) chelator (EGTA) and CaM antagonists (CPZ and TFP) suppressed NPPB-elevated cytosolic Ca(2+) fluorescence intensity and CaM concentration in tea roots, respectively.
Bioanalytical approaches to assess the proteolytic stability of therapeutic fusion proteins.
Rock et al., San Francisco, United States. In Bioanalysis, Dec 2015
Characterizing the proteolytic liabilities of a TFP can guide engineering efforts to inhibit or hinder partial proteolysis.
Effective treatment of hypertension by recombinant Lactobacillus plantarum expressing angiotensin converting enzyme inhibitory peptide.
Wang et al., Changchun, China. In Microb Cell Fact, 2014
Angiotensin-converting enzyme inhibitory peptides (ACEIPs), which are made from tuna frame protein (TFP) and yellow fin sole frame protein (YFP), have been used previously to treat hypertension.
Regulation of Type IV Pili Contributes to Surface Behaviors of Historical and Epidemic Strains of Clostridium difficile.
Tamayo et al., Chapel Hill, United States. In J Bacteriol, 2014
Recent findings that flagellar motility, toxin synthesis, and type IV pilus (TFP) formation are regulated by cyclic diguanylate (c-di-GMP) reveal the importance of this second messenger for C. difficile gene regulation.
Retraction of enteropathogenic E. coli type IV pili promotes efficient host cell colonization, effector translocation and tight junction disruption.
Donnenberg et al., Jerusalem, Israel. In Gut Microbes, 2012
Type IV pili (Tfp) play a primary role in mediating the adherence of pathogenic bacteria to their hosts.
Observations regarding retinopathy in mitochondrial trifunctional protein deficiencies.
Gillingham et al., Portland, United States. In Mol Genet Metab, 2012
Trifunctional protein is a heteroctomer; two genes encode the alpha and beta subunits of TFP respectively, HADHA and HADHB.
Psychological therapies for people with borderline personality disorder.
Lieb et al., Freiburg, Germany. In Cochrane Database Syst Rev, 2011
Interventions were classified as comprehensive psychotherapies if they included individual psychotherapy as a substantial part of the treatment programme, or as non-comprehensive if they did not.Among comprehensive psychotherapies, dialectical behaviour therapy (DBT), mentalisation-based treatment in a partial hospitalisation setting (MBT-PH), outpatient MBT (MBT-out), transference-focused therapy (TFP), cognitive behavioural therapy (CBT), dynamic deconstructive psychotherapy (DDP), interpersonal psychotherapy (IPT) and interpersonal therapy for BPD (IPT-BPD) were tested against a control condition.
TRIM39 and RNF39 are associated with Behçet's disease independently of HLA-B∗51 and -A∗26.
Inoko et al., Isehara, Japan. In Biochem Biophys Res Commun, 2010
these findings suggest that RNF39 and TRIM39 are involved in the etiology of Behcet's disease.
Mitochondrial fatty acid oxidation disorders: clinical presentation of long-chain fatty acid oxidation defects before and after newborn screening.
Spiekerkoetter, Düsseldorf, Germany. In J Inherit Metab Dis, 2010
Only in disorders of the mitochondrial trifunctional protein (TFP) complex, including long-chain 3-hydroxyacyl-coenzyme A (CoA) dehydrogenase (LCHAD) deficiency, neuropathy and retinopathy develop that are progressive and irreversible despite current treatment measures.
TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process.
Yu et al., Singapore, Singapore. In Exp Cell Res, 2009
Data suggest that TRIM39 can promote apoptosis signalling through stabilization of MOAP-1.
Pilus retraction powers bacterial twitching motility.
Sheetz et al., Portland, United States. In Nature, 2000
Type IV pili (Tfp) are required for twitching and social gliding, but the mechanism by which these filaments promote motility has remained enigmatic.
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