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Transcription factor EC

TFEC, Tcfec, transcription factor EC, mTFEC
This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: TFE3, Microphthalmia-Associated Transcription Factor, TFEB, CAN, ACID
Papers using TFEC antibodies
A novel imaging technique for experimental choroidal neovascularization.
van Heyningen Veronica, In PLoS Genetics, 2005
... Tyr-Tfec transgenic mice (strain C57BL/6N) were ...
Papers on TFEC
Association between gene and miRNA expression profiles and stereotyped subset #4 B-cell receptor in chronic lymphocytic leukemia.
Neri et al., Milano, Italy. In Leuk Lymphoma, Nov 2015
Gene and miRNA expression profiling evidenced that the leukemic cells of subset #4 cases showed significant downregulation of WDFY4, MF2A and upregulation of PDGFA, FGFR1 and TFEC gene transcripts, as well as the upregulation of miR-497 and miR-29c.
MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5.
Youle et al., Bethesda, United States. In J Cell Biol, Sep 2015
Analysis of clustered regularly interspaced short palindromic repeats-generated TFEB/MITF/TFE3/TFEC single, double, and triple knockout cell lines revealed that these proteins partly facilitate Parkin-mediated mitochondrial clearance.
Integrated microRNA-mRNA analysis of coronary artery disease.
Ma et al., Shanghai, China. In Mol Biol Rep, 2014
Further analysis showed miR-545-TFEC and miR-585-SPOCK1 were highly positively correlated (ρ = 0.808091264; ρ = 0.874680776) in CAD samples.
Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis.
Puertollano et al., Bethesda, United States. In Cell Mol Life Sci, 2014
The MiTF/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF, TFEB, TFE3, and TFEC.
Identification of non-cell-autonomous networks from engineered feeder cells that enhance murine hematopoietic stem cell activity.
Sauvageau et al., Montréal, Canada. In Exp Hematol, 2013
Five of these factors, namely FOS, SPI1, KLF10, TFEC, and PRDM16, show robust transcriptional cross-regulation and are often associated with osteoclastogenesis.
The CD20 homolog Ms4a8a integrates pro- and anti-inflammatory signals in novel M2-like macrophages and is expressed in parasite infection.
Goerdt et al., Mannheim, Germany. In Eur J Immunol, 2012
Upregulation of Hdc, Tcfec, and Sla was confirmed both in primary LPS/dexamethasone/IL-4-stimulated Ms4a8a(+) BMDMs and in peritoneal macrophages from late-stage Taenia crassiceps infection.
A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development.
Arnheiter et al., Bethesda, United States. In Plos Genet, 2012
Gene expression analyses show that, together with MITF or its paralog TFEC, PAX6 suppresses the expression of Fgf15 and Dkk3.
A genome-wide RNAi screen identifies novel targets of neratinib resistance leading to identification of potential drug resistant genetic markers.
Ryan et al., Cambridge, United States. In Mol Biosyst, 2012
FOXP4, TFEC, ZNF), cellular ion transport (e.g.
Cell line derived multi-gene predictor of pathologic response to neoadjuvant chemotherapy in breast cancer: a validation study on US Oncology 02-103 clinical trial.
Pusztai et al., Pittsburgh, United States. In Bmc Med Genomics, 2011
The chemotherapy predictor (TFEC-MGP) was developed from publicly available gene expression data of 42 breast cancer cell-lines with corresponding in vitro chemotherapy sensitivity results for the four chemotherapy drugs.
Embryonic expression of zebrafish MiT family genes tfe3b, tfeb, and tfec.
Lunney et al., Richmond, United States. In Dev Dyn, 2011
The MiT family comprises four genes in mammals: Mitf, Tfe3, Tfeb, and Tfec, which encode transcription factors of the basic-helix-loop-helix/leucine zipper class.
Biology and clinical relevance of the micropthalmia family of transcription factors in human cancer.
Fisher et al., Boston, United States. In J Clin Oncol, 2011
Members of the micropthalmia (MiT) family of transcription factors (MITF, TFE3, TFEB, and TFEC) are physiologic regulators of cell growth, differentiation, and survival in several tissue types.
Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1.
Goerdt et al., Mannheim, Germany. In Hepatology, 2010
The LSEC differentiation program comprised distinct sets of growth (Wnt2, Fzd4, 5, 9, Wls, vascular endothelial growth factors [VEGFR] 1, 2, 3, Nrp2) and transcription factors (Gata4, Lmo3, Tcfec, Maf) as well as endocytosis-related (Stabilin-1/2, Lyve1, and Ehd3) and cytoskeleton-associated molecules (Rnd3/RhoE).
Dynamic patterning at the pylorus: formation of an epithelial intestine-stomach boundary in late fetal life.
Gumucio et al., Ann Arbor, United States. In Dev Dyn, 2009
We identify specific transcription factors (Hnf4 gamma, Creb3l3, and Tcfec) and examine signaling pathways (Hedgehog and Wnt) that may play a role in this process.
A functional screen to identify novel effectors of hematopoietic stem cell activity.
Sauvageau et al., Montréal, Canada. In Cell, 2009
Interestingly, at least four of the 18 factors, Fos, Tcfec, Hmgb1, and Sfpi1, show non-cell-autonomous functions.
Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor.
Andreesen et al., Regensburg, Germany. In J Immunol, 2005
Transcription factor EC, along with several other transcription factors, is a Stat6-dependent target of IL-4.
Melanocytes and the microphthalmia transcription factor network.
Jenkins et al., Reykjavík, Iceland. In Annu Rev Genet, 2003
Like Myc, Mitf regulates gene expression by binding to DNA as a homodimer or as a heterodimer with another related family member, in the case of Mitf the Tfe3, Tfeb, and Tfec proteins.
TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells.
Kawamoto et al., Bethesda, United States. In Biochemistry, 2001
Two alternatively spliced TFEC isoforms have been found to be sequence-specific transcriptional activators of the nonmuscle myosin II heavy chain-A gene in transfected cells.
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