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Transcription factor binding to IGHM enhancer 3

The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1); it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.[provided by RefSeq, Dec 2009] (from NCBI)
Top mentioned proteins: XRCC1, HAD, CAN, TFEB, Microphthalmia-Associated Transcription Factor
Papers using TFE3 antibodies
A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells.
Bryk Mary, In PLoS ONE, 1990
... ); Human TFE3 siRNA pool (siTFE3, Thermo Scientific, L-009363-00-0005); Mouse Flcn siRNA ...
Papers on TFE3
ALK-Rearranged Renal Cell Carcinomas in Children.
Perlman et al., Omaha, United States. In Genes Chromosomes Cancer, Feb 2016
In our review of 168 pediatric RCC prospectively registered on Children's Oncology Group AREN03B2 protocol, we identified six RCC (3.5%) that demonstrated a unique epithelioid morphology and a peculiar immunophenotypic profile that includes expression of ALK, TFE3 and retention of INI1.
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
Zuna et al., In N Engl J Med, Feb 2016
Type 1 tumors were associated with MET alterations, whereas type 2 tumors were characterized by CDKN2A silencing, SETD2 mutations, TFE3 fusions, and increased expression of the NRF2-antioxidant response element (ARE) pathway.
Unsuspected Xp11 Translocation Renal Neoplasm Associated With Contralateral Clear Cell Carcinoma.
Zeppa et al., Pagani, Italy. In Int J Surg Pathol, Feb 2016
Immunohistochemical panel showed negativity for cytokeratin-pan, cytokeratin-7, PAX8, and CD10 but positive immunostaining for cathepsin K, racemase, Melan-A, and TFE3.
Cardiopulmonary bypass-assisted surgery for the treatment of Xp11.2 translocation/TFE3 gene fusion renal cell carcinoma with a tumor thrombus within the inferior vena cava: A case report.
Guo et al., Nanjing, China. In Oncol Lett, Dec 2015
Xp11.2 translocation/TFE3 gene fusion RCC is currently classified as a distinct type of RCC.
Alveolar Soft Part Sarcoma.
Kirby et al., Iowa City, United States. In Arch Pathol Lab Med, Nov 2015
It is characterized by a specific chromosomal alteration, der(17)t(X:17)(p11:q25), resulting in fusion of the transcription factor E3 (TFE3) with alveolar soft part sarcoma critical region 1 (ASPSCR1) at 17q25.
MiT Family Translocation-Associated Renal Cell Carcinoma: A Contemporary Update With Emphasis on Morphologic, Immunophenotypic, and Molecular Mimics.
Mehra et al., Ann Arbor, United States. In Arch Pathol Lab Med, Oct 2015
Translocation-associated renal cell carcinoma (t-RCC) is a relatively uncommon subtype of renal cell carcinoma characterized by recurrent gene rearrangements involving the TFE3 or TFEB loci.
Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome.
Linehan et al., Bethesda, United States. In Nat Rev Urol, Oct 2015
Emerging evidence links FLCN with a number of other molecular pathways and cellular processes important for cell homeostasis that are frequently deregulated in cancer, including regulation of TFE3 and/or TFEB transcriptional activity, amino-acid-dependent mTOR activation through Rag GTPases, TGFβ signalling, PGC1α-driven mitochondrial biogenesis, and autophagy.
[Novel biomarkers in renal cell carcinoma : Identification and functional characterization].
Macher-Göppinger, Heidelberg, Germany. In Pathologe, Oct 2015
Furthermore, our data demonstrate that molecular tests are necessary to correctly classify a RCC with Xp11.2 translocation, since in addition to translocation, amplification can also result in TFE3 activation.
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.
Bardeesy et al., Boston, United States. In Nature, Sep 2015
In human PDA cells, the MiT/TFE proteins--MITF, TFE3 and TFEB--are decoupled from regulatory mechanisms that control their cytoplasmic retention.
Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment.
Jones et al., Salt Lake City, United States. In Cancer Cell, 2015
Alveolar soft part sarcoma (ASPS), a deadly soft tissue malignancy with a predilection for adolescents and young adults, associates consistently with t(X;17) translocations that generate the fusion gene ASPSCR1-TFE3.
Expression of CD44 and CD29 by PEComa cells suggests their possible origin of mesenchymal stem cells.
Li et al., Shihezi, China. In Int J Clin Exp Pathol, 2014
In addition to observed histopathologic morphology, we also performed PEComa relevant clinical diagnostic markers (HMB-45, SMA, melan-A, Desmin, Ki-67, S-100 and TFE3) to identify whether they belonged to PEComas.
Markers of Pluripotency in Human Amniotic Epithelial Cells and Their Differentiation to Progenitor of Cortical Neurons.
Díaz et al., Ciudad López Mateos, Mexico. In Plos One, 2014
Also, we determined the presence of OCT4, SOX2, NANOG, SSEA3, SSEA4, TRA-1-60, E-cadherin, KLF4, TFE3 as well as the proliferation and epigenetic state by immunocytochemistry of the cells.
Landscape of gene fusions in epithelial cancers: seq and ye shall find.
Chinnaiyan et al., Ann Arbor, United States. In Genome Med, 2014
Tumor-specific gene fusions can serve as diagnostic biomarkers or help define molecular subtypes of tumors; for example, gene fusions involving oncogenes such as ERG, ETV1, TFE3, NUT, POU5F1, NFIB, PLAG1, and PAX8 are diagnostically useful.
Transcription factor E3, a major regulator of mast cell-mediated allergic response.
Nechushtan et al., Jerusalem, Israel. In J Allergy Clin Immunol, 2012
a major regulator of mast cell-mediated allergic response
Translocation renal cell carcinomas in adults: a single-institution experience.
Cai et al., New York City, United States. In Am J Surg Pathol, 2012
Describes the clinical and histopathologic features of TFE3 and TFEB translocation renal cell carcinoma.
Perivascular epithelioid cell tumors (PEComas) harboring TFE3 gene rearrangements lack the TSC2 alterations characteristic of conventional PEComas: further evidence for a biological distinction.
Argani et al., In Am J Surg Pathol, 2012
Perivascular epithelioid cell tumors with TFE3 gene fusions demonstrated intact, robust tuberin protein labeling and no TSC2 loss of heterozygosity.
TFE3 rearrangements in adult renal cell carcinoma: clinical and pathologic features with outcome in a large series of consecutively treated patients.
Cheville et al., Rochester, United States. In Am J Surg Pathol, 2012
Results suggest that adult renal cell carcinoma with TFE3 rearrangement may be a clinically aggressive tumor.
TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice.
Shimano et al., Tsukuba, Japan. In Am J Physiol Endocrinol Metab, 2012
The potential role of TFE3 in regulating metabolic genes and glucose metabolism within skeletal muscle suggests that it may be used for treating metabolic diseases
Biology and clinical relevance of the micropthalmia family of transcription factors in human cancer.
Fisher et al., Boston, United States. In J Clin Oncol, 2011
Members of the micropthalmia (MiT) family of transcription factors (MITF, TFE3, TFEB, and TFEC) are physiologic regulators of cell growth, differentiation, and survival in several tissue types.
Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity.
Roman et al., New York City, United States. In Nat Immunol, 2006
Maximum Cd40lg promoter activity and gene expression required TFE3 or TFEB.
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