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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Transcription factor 4

TFE, Me2, E2-2, Celsr1
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, SDSL, V1a
Papers using TFE antibodies
Structure-guided de novo design of α-helical antimicrobial peptide with enhanced specificity
Chen Yu-Xin et al., In International Journal of Molecular Sciences, 2009
... -α-Fmoc protected amino acids and coupling reagents for peptide synthesis, trifluoroacetic acid (TFA), 2,2,2-trifluoroethanol (TFE) were purchased from GL Biochem (Shanghai, China) ...
Phosphatidylethanolamine mediates insertion of the catalytic domain of leader peptidase in membranes
Raja Mobeen, In The Journal of Membrane Biology, 1997
... 2,2,2-Trifluoroethanol (TFE) was obtained from Merck.
Papers on TFE
Source regional contributions to PM2.5 in a megacity in China using an advanced source regional apportionment method.
Feng et al., Tianjin, China. In Chemosphere, Feb 2016
Sources were determined by Multilinear Engine 2 (ME2) model, and results showed that the PM2.5 in Tianjin was mainly influenced by secondary sulphate & secondary organic carbon SOC (percent contribution of 26.2%), coal combustion (24.6%), crustal dust & cement dust (20.3%), secondary nitrate (14.9%) and traffic emissions (14.0%).
Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway.
Botas et al., Houston, United States. In Autophagy, Feb 2016
In mammals, TFEB and other members of the MiTF-TFE family of transcription factors control this network.
Lateral orbitotomy for a maxillary nerve schwannoma: case report.
Cho et al., Bethesda, United States. In J Neurosurg, Feb 2016
UNASSIGNED: Authors of this report describe a Fukushima Type D(b) or Kawase Type ME2 trigeminal schwannoma involving the right maxillary division in a 59-year-old woman who presented with intermittent right-sided facial numbness and pain.
3,3'-Diindolylmethane Inhibits Flt3L/GM-CSF-induced-bone Marrow-derived CD103(+) Dendritic Cell Differentiation Regulating Phosphorylation of STAT3 and STAT5.
Jeong et al., Ch'angwŏn, South Korea. In Immune Netw, Dec 2015
DIM interfered with phosphorylation of STAT3 and STAT5 inhibiting the expression of genes, including Id2, E2-2, IDO-1, and Aldh1a2, which are associated with DC differentiation and functions.
Study of conformational properties of solid phase synthesized ovine kisspeptin-14 using Circular Dichroism spectroscopy.
Naqvi et al., In Indian J Exp Biol, Oct 2015
However, the peptide adopted more ordered β-sheet conformation in the solvents such as TFE and HFIP.
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.
Bardeesy et al., Boston, United States. In Nature, Sep 2015
Here we show that autophagy induction in PDA occurs as part of a broader transcriptional program that coordinates activation of lysosome biogenesis and function, and nutrient scavenging, mediated by the MiT/TFE family of transcription factors.
Beyond indigestion: emerging roles for lysosome-based signaling in human disease.
Ferguson, New Haven, United States. In Curr Opin Cell Biol, Aug 2015
This is illustrated by the discovery of a growing number of lysosome-localized proteins that respond to changes in growth factor and nutrient availability to regulate mTORC1 signaling as well as the identification of MiT/TFE transcription factors (MITF, TFEB and TFE3) as proteins that shuttle between lysosomes and the nucleus to elicit a transcriptional response to ongoing changes in lysosome status.
PEComas of the kidney and of the genitourinary tract.
Bonetti et al., Verona, Italy. In Semin Diagn Pathol, Mar 2015
In addition, a distinctive subset of PEComas harboring TFE3 gene fusions has been reported, giving rise to a possible relationship between them and MiTF/TFE family translocation renal cell carcinomas.
Identification of a novel antimicrobial peptide from amphioxus Branchiostoma japonicum by in silico and functional analyses.
Zhang et al., Qingdao, China. In Sci Rep, 2014
Moreover, the synthesized putative mature AMP, mBjAMP1, underwent a coil-to-helix transition in the presence of TFE or SDS, agreeing well with the expectation that BjAMP1 was a potential AMP.
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Schiöth et al., Amsterdam, Netherlands. In Pharmacol Rev, 2014
The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98).
Understanding cadherin EGF LAG seven-pass G-type receptors.
Sun et al., Jinan, China. In J Neurochem, 2014
All three members of the CELSR family (CELSR1-3) have large ecto-domains that form homophilic interactions and encompass more than 2000 amino acids.
Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation.
Jarriault et al., Strasbourg, France. In Science, 2014
We report that a conserved H3K27me3/me2 demethylase, JMJD-3.1, and the H3K4 methyltransferase Set1 complex cooperate to ensure invariant transdifferentiation (Td) of postmitotic Caenorhabditis elegans hindgut cells into motor neurons.
Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives.
Cano et al., Madrid, Spain. In Cancer Manag Res, 2013
The EMT triggering leads to the activation of a core of transcription factors (EMT-TFs) - SNAIL1/SNAIL2, bHLH (E47, E2-2, and TWIST1/TWIST2), and ZEB1/ZEB2 - that act as E-cadherin repressors and, ultimately, coordinate EMT.
A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential.
Ohteki et al., Tokyo, Japan. In Immunity, 2013
Although both MDPs and CDPs express the macrophage colony stimulating factor (M-CSF) receptor (M-CSFR), the progenitors were confined to a M-CSFR(-) fraction, identified as Lin(-)c-Kit(int/lo)Flt3(+)M-CSFR(-), and expressed high amounts of E2-2 (also known as Tcf4) an essential transcription factor for pDC development.
Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence.
Yang et al., Philadelphia, United States. In Nature, 2013
We show that p53 represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 in human and mouse cells.
Role of the planar cell polarity gene CELSR1 in neural tube defects and caudal agenesis.
Kibar et al., Montréal, Canada. In Birth Defects Res A Clin Mol Teratol, 2012
CELSR1 is a risk factor for neural tube defects or caudal agenesis via pathogenic role of planar cell polarity signaling in these malformations.
Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis.
Stanier et al., London, United Kingdom. In Hum Mutat, 2012
Missense variants in CELSR1 may represent a cause of craniorachischisis in humans, as in mice, with defective planar cell polarity protein trafficking to the plasma membrane a likely pathogenic mechanism.
The GM-CSF receptor utilizes β-catenin and Tcf4 to specify macrophage lineage differentiation.
D'Andrea et al., Adelaide, Australia. In Differentiation, 2012
We show that forced expression of Tcf4 or a stabilised beta-catenin mutant is sufficient to promote macrophage differentiation in response to GM-CSF and that GM-CSF can regulate beta-catenin stability, most likely via GSK3b.
Multi-level interactions between the nuclear receptor TRα1 and the WNT effectors β-catenin/Tcf4 in the intestinal epithelium.
Plateroti et al., Lyon, France. In Plos One, 2011
increased beta-catenin/Tcf4 levels i) correlated with reduced TRalpha1 transcriptional activity on its target genes and, ii) were likely responsible for the shift of TRalpha1 binding on WNT targets
Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury.
Botchkarev et al., Bradford, United Kingdom. In Development, 2011
Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury.
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