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Testis-specific kinase 1

TESK1, testicular protein kinase 1, testis-specific protein kinase 1
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, cofilin, ACID, fibronectin, LIMK2
Papers on TESK1
Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation.
Kim et al., Taejŏn, South Korea. In Embo J, Jan 2016
Our siRNA library screening identifies actin dynamics regulator TESK1 as a novel vulnerable point of the YAP/TAZ-dependent resistance pathway.
Distinct differences in global gene expression profiles in non-implanted blastocysts and blastocysts resulting in live birth.
Lykke-Hartmann et al., Århus, Denmark. In Gene, Nov 2015
EFNB1, CYTL1 and TEX26 and TESK1, MSL1 and EVI5 in trophectoderm biopsies associated with live birth and non-implanting, respectively.
Differential Genes Expression between Fertile and Infertile Spermatozoa Revealed by Transcriptome Analysis.
Rajender et al., Lucknow, India. In Plos One, 2014
Some of these transcripts were related to heat shock proteins (DNAJB4, DNAJB14), testis specific genes (TCP11, TESK1, TSPYL1, ADAD1), and Y-chromosome genes (DAZ1, TSPYL1).
Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking.
Kim et al., Taejŏn, South Korea. In Nat Commun, 2014
We also identify actin remodelling factors LIMK2 and TESK1 as key players in the ciliogenesis control network in which YAP/TAZ and directional vesicle trafficking are integral components.
Kinome-wide functional analysis highlights the role of cytoskeletal remodeling in somatic cell reprogramming.
Rana et al., Los Angeles, United States. In Cell Stem Cell, 2014
We found that shRNA-mediated knockdown of the serine/threonine kinases TESK1 or LIMK2 promoted mesenchymal-to-epithelial transition, decreased COFILIN phosphorylation, and disrupted Actin filament structures during reprogramming of mouse embryonic fibroblasts.
Cloning and characterization of tesk1, a novel spermatogenesis-related gene, in the tongue sole (Cynoglossus semilaevis).
Chen et al., Qingdao, China. In Plos One, 2013
Testis-specific protein kinase 1 (Tesk1) is a serine/threonine kinase with unique structural features.
Spatiotemporal expression of testicular protein kinase 1 after rat sciatic nerve injury.
Wang et al., Nantong, China. In J Mol Neurosci, 2012
Testicular protein kinase 1 (TESK1), a serine/threonine kinase, has been found expressing in various tissues and cell lines.
Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.
Xavier et al., Boston, United States. In Plos Pathog, 2011
Using an expression screen we identify FLRT3, C22orf28 and TESK1 as novel activators of SRF.
Temporal blastemal cell gene expression analysis in the kidney reveals new Wnt and related signaling pathway genes to be essential for Wilms' tumor onset.
Carraro et al., São Paulo, Brazil. In Cell Death Dis, 2010
The protein expression of CRABP2, IGF2, GRK7, TESK1, HDGF, WNT5B, FZD2 and TIMP3 was characterized in WTs and in a panel of human fetal kidneys displaying remarkable aspects of differentiation, which was recapitulated in the tumor.
Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton.
Mandelkow et al., Hamburg, Germany. In Mol Biol Cell, 2008
enhanced TESK1 activity results in increased stress fibers (via phospho-cofilin), but this can be blocked by elevating Spred1
Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.
Guy et al., Singapore, Singapore. In J Biol Chem, 2008
By selectively modulating the downstream effects of Spry2, Tesk1 may thus serve as a molecular determinant of the signaling outcome.
The Cdi/TESK1 kinase is required for Sevenless signaling and epithelial organization in the Drosophila eye.
Serras et al., Barcelona, Spain. In J Cell Sci, 2007
Cdi is homologous to the human testis-specific kinase 1 (TESK1), a member of the LIM kinases involved in cytoskeleton control through ADF/cofilin phosphorylation.
Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin.
Turner et al., Syracuse, United States. In J Biol Chem, 2005
the association between actopaxin and TESK1, which is likely regulated by phosphorylation of actopaxin, regulates TESK1 activity and subsequent cellular spreading on fibronectin
Sprouty-4 negatively regulates cell spreading by inhibiting the kinase activity of testicular protein kinase.
Mizuno et al., Sendai, Japan. In Biochem J, 2005
TESK1 (testicular protein kinase 1) is a serine/threonine kinase that phosphorylates cofilin and plays a critical role in integrin-mediated actin cytoskeletal reorganization and cell spreading.
[Establishment of animal model for in vitro spermatogenesis by heterotopic grafting of neonatal mouse testis].
Cai et al., Shenzhen, China. In Beijing Da Xue Xue Bao, 2004
METHODS: Tissue grafting was performed using testis from 1-2 days old Kun-ming mice as donor tissue and immunodefective mice as recipients; the expression of TESK1 mRNA in grafts was determined by RT-PCR and the spermatogenesis further observed with histological analysis of grafts.
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