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Adenosine deaminase domain containing 1

Tenr, testis nuclear RNA-binding protein
Top mentioned proteins: HAD, DPB1, CTLA-4, PTPN22, PBC
Papers on Tenr
The genetic basis of graves' disease.
Bednarczuk et al., Warsaw, Poland. In Curr Genomics, 2011
We review recent findings implicating variants of FCRL3 (gene for FC receptor-like-3 protein), SCGB3A2 (gene for secretory uteroglobin-related protein 1- UGRP1) as well as other unverified possible candidate genes for GD selected through their documented association with type 1 diabetes mellitus: Tenr-IL2-IL21, CAPSL (encoding calcyphosine-like protein), IFIH1(gene for interferon-induced helicase C domain 1), AFF3, CD226 and PTPN2.
Analysis of IL2/IL21 gene variants in cholestatic liver diseases reveals an association with primary sclerosing cholangitis.
Pusl et al., München, Germany. In Digestion, 2010
METHODS: Four strongly UC-associated single nucleotide polymorphisms (SNPs) within the KIAA1109/TENR/IL2/IL21 linkage disequilibrium block were genotyped in 124 PBC and 41 PSC patients.
Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance.
Merriman et al., Dunedin, New Zealand. In Arthritis Res Ther, 2009
The KIAA1109-TENR-IL2-IL21 gene cluster, that encodes an interleukin (IL-21) that plays an important role in Th17 cell biology, is the 20th locus for which there is a genome-wide level of support for association with rheumatoid arthritis.
Multiple sclerosis association study with the TENR-IL2-IL21 region in a Spanish population.
Matesanz et al., Granada, Spain. In Tissue Antigens, 2009
Polymorphisms from the TENR-IL2-IL21 block in the 4q27 chromosome were recently associated with type 1 diabetes, celiac disease, rheumatoid arthritis and psoriasis.
Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease.
Brand et al., München, Germany. In Am J Gastroenterol, 2009
METHODS: Five SNPs strongly associated with celiac disease within the KIAA1109/TENR/IL2/IL21 linkage disequilibrium block on chromosome 4q27 and one coding SNP within the IL21 gene were analyzed in a large German IBD cohort.
Origins and evolution of ADAR-mediated RNA editing.
Li et al., Hangzhou, China. In Iubmb Life, 2009
ADAR1 and ADAR2 arose by gene duplications in early metazoan evolution, approximately 700 million years ago, while ADAR3 and TENR might originate after Urochordata-Vertebrata divergence.
Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study.
European Consortium on Rheumatoid Arthritis Families et al., Paris, France. In Arthritis Res Ther, 2008
Using a family-based study, we have provided a trend for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in populations of European descent
Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families.
Torinsson Naluai et al., Göteborg, Sweden. In Genes Immun, 2008
The first genome-wide association study performed in a UK coeliac disease (CD) case-control cohort revealed association with a linkage disequilibrium block containing the KIAA1109/Tenr/IL2/IL21 genes.
Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.
Wijmenga et al., Utrecht, Netherlands. In Am J Hum Genet, 2007
Recently, association of celiac disease with common single-nucleotide polymorphism (SNP) variants in an extensive linkage-disequilibrium block of 480 kb containing the KIAA1109, Tenr, IL2, and IL21 genes has been demonstrated in three independent populations (rs6822844P combined=1.3 x 10(-14)).
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
Wijmenga et al., London, United Kingdom. In Nat Genet, 2007
Genetic variation in a linkage disequilibrium block encompassing the KIAA1109-TENR-IL2-IL21 genes predisposes to celiac disease.
Disruption of murine Tenr results in teratospermia and male infertility.
Braun et al., Seattle, United States. In Dev Biol, 2005
Targeted mutation of the Tenr gene causes male sterility. Tenr mutant males have a reduced sperm count, and Tenr-/- sperm show a decrease in motility and an increase in malformed heads.
Crystal structure of TB-RBP, a novel RNA-binding and regulating protein.
Robertus et al., Austin, United States. In J Mol Biol, 2002
2.65 A crystal structure of mouse TB-RBP
Statistical modelling and phylogenetic analysis of a deaminase domain.
Chatterjee et al., Berkeley, United States. In J Comput Biol, 1997
In some of the newly identified DM domains, the glutamate is changed to a residue that could not function as a proton shuttle and in one instance (Mus musculus spermatid protein TENR) the cysteines are also changed to lysine and serine.
Distribution of Tenr, an RNA-binding protein, in a lattice-like network within the spermatid nucleus in the mouse.
Braun et al., Seattle, United States. In Biol Reprod, 1995
In a molecular screen for cDNAs that encode protamine RNA-binding proteins, we obtained seven independent clones that encode Tenr, a testis nuclear RNA-binding protein.
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