Local trauma in human patellar tendon leads to widespread changes in the tendon gene expression.
Nottingham, United Kingdom. In J Appl Physiol, Feb 2016
Results for DNA content were inconclusive, and no changes were detected in expression of Insulin-like growth factor-I, connective tissue growth factor, scleraxis, decorin, fibromodulin, tenascin-C, tenomodulin, VEGFa, CD68, IL-6, MMP12 and MMP13.
Tenogenic induction of equine mesenchymal stem cells by means of growth factors and low-level laser technology.
Padova, Italy. In Vet Res Commun, Feb 2016
PB-MSCs were used to study the effects of the addition of some growth factors (GFs) as TGFβ3 (transforming growth factor), EGF2 (Epidermal growth factor), bFGF2 (Fibroblast growth factor) and IGF-1 (insulin-like growth factor) in presence or without Low Level Laser Technology (LLLT) on the mRNA expression levels of genes important in the tenogenic induction as Early Growth Response Protein-1 (EGR1), Tenascin (TNC) and Decorin (DCN).
Molecular identity of human outer radial glia during cortical development.
San Francisco, United States. In Cell, Oct 2015
By analyzing gene expression across single cells, we find that outer radial glia preferentially express genes related to extracellular matrix formation, migration, and stemness, including TNC, PTPRZ1, FAM107A, HOPX, and LIFR.
The Function of Matricellular Proteins in the Lamina Cribrosa and Trabecular Meshwork in Glaucoma.
Dublin, Ireland. In J Ocul Pharmacol Ther, Sep 2015
Matricellular proteins are a family of nonstructural secreted glycoproteins, which enable cells to communicate with their surrounding ECM, including CTGF, also known as CCN2, TSPs, SPARC, periostin, osteonectin, and tenascin-C and -X, and other ECM proteins.
Tenascin-C: Its functions as an integrin ligand.
Davis, United States. In Int J Biochem Cell Biol, Aug 2015
This review summarizes the experimental evidence of tenascin-C/integrin interactions, emphasizing the identification of integrin binding sites and the effects of specific interactions on cell behavior.
Tenascin-X: beyond the architectural function.
Lyon, France. In Cell Adh Migr, 2014
Tenascin-X is the largest member of the tenascin (TN) family of evolutionary conserved extracellular matrix glycoproteins, which also comprises TN-C, TN-R and TN-W.
Matricellular proteins in cardiac adaptation and disease.
United States. In Physiol Rev, 2012
Thrombospondin (TSP)-1, -2, and -4 as well as tenascin-C and -X secreted protein acidic and rich in cysteine (SPARC), osteopontin, periostin, and members of the CCN family (including CCN1 and CCN2/connective tissue growth factor) are involved in a variety of cardiac pathophysiological conditions, including myocardial infarction, cardiac hypertrophy and fibrosis, aging-associated myocardial remodeling, myocarditis, diabetic cardiomyopathy, and valvular disease.