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Tektin 1

This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GDF9, SCP3, BOULE, Acrosin, MLH1
Papers on TEKT1
Bone morphogenetic protein 4 (BMP4) induces buffalo (Bubalus bubalis) embryonic stem cell differentiation into germ cells.
Chauhan et al., Karnāl, India. In Biochimie, Dec 2015
qPCR analysis revealed that BMP4 at a concentration of 50-100 ngml(-1) for a culture period of 14 days led to maximum induction of germ lineage genes like DAZL, VASA, PLZF (PGC-specific); SYCP3, MLH1, TNP1/2 and PRM2 (Meiotic genes); BOULE and TEKT1 (Spermatocyte markers); GDF9, ZP2 and 3 (Oocyte markers).
Cumulus cell-conditioned medium supports embryonic stem cell differentiation to germ cell-like cells.
Chauhan et al., In Reprod Fertil Dev, Dec 2015
Quantitative polymerase chain reaction analysis revealed that 20%-40% CCM induced the highest expression of primordial germ cell-specific (deleted in Azoospermia- like (Dazl), dead (Asp-Glu-Ala-Asp) box polypeptide 4 (Vasa also known as DDX4) and promyelocytic leukemia zinc finger protein (Plzf)); meiotic (synaptonemal complex protein 3 (Sycp3), mutl homolog I (Mlh1), transition protein 1/2 (Tnp1/2) and protamine 2 (Prm2); spermatocyte-specific boule-like RNA binding protein (Boule) and tektin 1 (Tekt1)) and oocyte-specific growth differentiation factor 9 (Gdf9) and zona pellucida 2 /3 (Zp2/3)) genes over 8-14 days in culture.
Comparative analysis of testis transcriptomes from triploid and fertile diploid cyprinid fish.
Liu et al., Changsha, China. In Biol Reprod, Apr 2015
A series of genes (DNAHs, DNAL1, IFTs, and DNAAF1) associated with sperm flagellar assembly and motility, and testis-specific candidate markers (Tcte1, Tekt1, Tekt4, Spag17, Spag5, Spag9a, Spag1b, and Spef2), had low expression levels in the testis of triploid fish.
Localization of Tektin 1 at both acrosome and flagella of mouse and bull spermatozoa.
Iida et al., Fukuoka, Japan. In Zoolog Sci, 2014
In mammals, five TEKTs (TEKT1, 2, 3, 4, and 5) have been identified in testis and spermatozoa.
Retinoic acid improve germ cell differentiation from human embryonic stem cells.
Guijin et al., Yantai, China. In Iran J Reprod Med, 2013
MATERIALS AND METHODS: hESCs were differentiated as embryoid bodies (EBs) in suspension with all-trans RA (atRA) or without atRA for 0, 1, 3, 5 and 7 days, and then the expression of VASA, SCP3, GDF9 and TEKT1 were compared by real-time PCR.
Male infertility and copy number variants (CNVs) in the dog: a two-pronged approach using Computer Assisted Sperm Analysis (CASA) and Fluorescent In Situ Hybridization (FISH).
Ventura et al., Bari, Italy. In Bmc Genomics, 2012
These two regions harbor two important genes for spermatogenesis: DNM2 and TEKT1.
Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni.
Keiser et al., Basel, Switzerland. In Acta Trop, 2011
The aim of this study was to characterize the fasciocidal properties of 1,2,4,5-tetraoxane (MT04 and MT14) and 1,2,4-trioxane (ST16 and ST28) analogues of the fasciocidal drug candidate OZ78, a 1,2,4-trioxolane.
Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study.
Gough et al., Birmingham, United Kingdom. In Eur J Hum Genet, 2010
Although none of these loci showed evidence of association with GD in the independent data set, when combined with the original Wellcome Trust Case-Control Consortium study group, minor differences in allele frequencies (P>or=10(-3)) remained in the combined collection of 5924 subjects for four of the nsSNPs, present within HDLBP, TEKT1, JSRP1 and UTX.
Tissue expression patterns identify mouse cilia genes.
Bergman et al., Lexington, United States. In Physiol Genomics, 2008
Tekt1 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Behavioral responses to odorants in drosophila require nervous system expression of the beta integrin gene myospheroid.
Grotewiel et al., Richmond, United States. In Chem Senses, 2006
Expression of mys-RNAi transgenes in the antennae, antennal lobes, and mushroom bodies via two Gal4 lines, H24 and MT14, disrupted olfactory behavior but did not alter locomotor abilities or central nervous system structure.
Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma.
Clark et al., San Francisco, United States. In Cancer, 2005
The adult meiotic germ cell markers BOULE and TEKT1 were undetectable in seminoma, whereas the embryonic and adult germ cell markers DAZL and VASA were significantly reduced.
Spontaneous differentiation of germ cells from human embryonic stem cells in vitro.
Pera et al., San Francisco, United States. In Hum Mol Genet, 2004
Upon ES cell differentiation into embryoid bodies (EBs), we observed a shift in expression from RNA and protein markers of immature germ cells to those indicative of mature germ cells, including expression of VASA, BOL, SCP1, SCP3, GDF9 and TEKT1.
Cloning and characterization of the human tektin-t gene.
Nishimune et al., Ōsaka, Japan. In Mol Hum Reprod, 2002
tektin-t localized specifically to the principal piece of sperm flagella and to the post-acrosomal region; the h-tektin-t gene was assigned to chromosome 1
Neutralizing human Fab fragments against measles virus recovered by phage display.
Björling et al., Stockholm, Sweden. In J Virol, 2002
In radioimmunoprecipitation assays two of the Fabs, MV12 and MT14, precipitated an approximately equal 80-kDa protein band corresponding to the hemagglutinin (H) protein from MV-infected Vero cell cultures, while two other Fabs, MT64 and GL29, precipitated an approximately equal 60-kDa protein corresponding the nucleocapsid (N) protein.
Cloning and characterization of a novel human TEKTIN1 gene.
Mao et al., Shanghai, China. In Int J Biochem Cell Biol, 2001
We hence named it the human TEKTIN1 gene.
The spatial and temporal expression of Tekt1, a mouse tektin C homologue, during spermatogenesis suggest that it is involved in the development of the sperm tail basal body and axoneme.
Höög et al., Stockholm, Sweden. In Eur J Cell Biol, 2000
Recently we described the sequence of the first mammalian tektin protein, Tekt1 (from mouse testis), which is most homologous with sea urchin tektin C. We have now investigated the temporal and spatial expression of Tekt1 during mouse male germ cell development.
Larval chemosensory projections and invasion of adult afferents in the antennal lobe of Drosophila.
Stocker et al., Fribourg, Switzerland. In J Neurobiol, 1997
P[GAL4] lines MT14 and KL116 demonstrate that adult antennal afferents have arrived in the antennal lobe 24 h after pupariation and extend to the contralateral lobe 6 h later.
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