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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

CAM1 Cam1p

TEF3, RTEF-1, TEAD4, eEF1Bgamma
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: fibrillin-1, YAP, CDX2, TEF, CAN
Papers on TEF3
RTEF-1 protects against oxidative damage induced by H2O2 in human umbilical vein endothelial cells through Klotho activation.
He et al., Wuhan, China. In Exp Biol Med (maywood), Dec 2015
Related transcriptional enhancer factor-1 (RTEF-1) has been suggested to regulate many genes expression which are involved in the endothelial angiogenesis and vasodilation.
9p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor-Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle Cells.
Stewart et al., Ottawa, Canada. In Circulation, Dec 2015
TEAD3 and TEAD4 overexpression induced p16 in HAoSMCs homozygous for the nonrisk allele, but not for the risk allele.
Increased TEAD4 expression and nuclear localization in colorectal cancer promote epithelial-mesenchymal transition and metastasis in a YAP-independent manner.
Cui et al., Shanghai, China. In Oncogene, Oct 2015
To further explore the potential role of Hippo pathway dysregulation in tumor development and progression, we investigated its downstream transcription factor TEAD4 in colorectal cancer (CRC).
Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival.
Wei et al., Nanjing, China. In Int J Cancer, Sep 2015
We used the genotyping data of 1,115 common single nucleotide polymorphisms (SNPs) in the 12 pathway core genes (i.e., MST1, MST2, SAV1, LATS1, LATS2, MOB1A, MOB1B, YAP1, TEAD1, TEAD2, TEAD3 and TEAD4) from the dataset of our previously published CM genome-wide association study and comprehensively analyzed their associations with CM-specific survival (CSS) in 858 CM patients by using the Kaplan-Meier analyses and Cox proportional hazards regression models.
Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth.
Oren et al., Israel. In Cell Death Differ, Aug 2015
TEAD4 mRNA was confirmed as a direct target of miR-512; likewise, miR-373 was found to target RelA and PIK3CA mRNA directly.
The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27Kip1.
Chen et al., Kunming, China. In Oncotarget, Aug 2015
Here we found that TEAD4 was expressed in breast cancer cell lines, especially in triple negative breast cancers (TNBC) cell lines.
Blastomeres aggregation as an efficient alternative for trophoblast culture from porcine parthenogenetic embryos.
Lee et al., Seoul, South Korea. In Dev Growth Differ, Jun 2015
The primary colonies derived from the ZPF embryos in both culture conditions were able to establish secondary and tertiary colonies and showed mRNA expression of CDX2, TEAD4 and KRT8 as trophoblast markers, while outgrowths from the ZPI embryos could not grow beyond primary colonies.
Characterization of the transcriptional activation domains of human TEF3-1 (transcription enhancer factor 3 isoform 1).
Liu et al., Wuhan, China. In Arch Biochem Biophys, Apr 2015
TEF3-1 (transcription enhancer factor 3 isoform 1) is a human transcriptional factor, which has a N-terminal TEA/ATTS domain supposedly for DNA binding and C-terminal PRD and STY domains for transcriptional activation.
Isolation and characterization of trophoblast-derived stem-like cells from peri-implantation porcine embryos.
Isom et al., Logan, United States. In Anim Reprod Sci, Mar 2015
Semiquantitative and quantitative gene expression analyses of cells in culture from 0 to 30 days confirmed the presence (and relative abundance) of mRNA transcripts from genes involved in trophoblast function (CDX2, TEAD4, CYP17A1, HSD17B1, FGFR2, PLET, HAND1) as well as some genes known to mediate pluripotency (POU5F1, KLF4, CMYC).
Transcriptional regulators in the Hippo signaling pathway control organ growth in Xenopus tadpole tail regeneration.
Yokoyama et al., Sendai, Japan. In Dev Biol, 2015
To examine the requirement of Hippo pathway transcriptional regulators in epimorphic regeneration, including organ size control, we inhibited these regulators during Xenopus tadpole tail regeneration by overexpressing a dominant-negative form of Yap (dnYap) or Tead4 (dnTead4) under a heat-shock promoter in transgenic animal lines.
The Efficient Derivation of Trophoblast Cells from Porcine In Vitro Fertilized and Parthenogenetic Blastocysts and Culture with ROCK Inhibitor Y-27632.
Li et al., Hohhot, China. In Plos One, 2014
The expression of TR lineage markers, such as CDX2, KRT7, KRT18, TEAD4, ELF5 and HAND1, imprinted genes such as IGF2, PEG1 and PEG10, and telomerase activity related genes TERC and TERF2 were detected by immunofluorescence staining, reverse transcription PCR and quantitative real-time PCR analyses.
miR-125a-5p impairs endothelial cell angiogenesis in aging mice via RTEF-1 downregulation.
Wang et al., Guangzhou, China. In Aging Cell, 2014
Western blot assays showed a lower expression level of an mir-125a-5p target known as related transcriptional enhancer factor-1 (RTEF-1) in OECs compared with its expression levels in young cells.
Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst.
Manzanares et al., Madrid, Spain. In Dev Cell, 2014
Here, we show an unsuspected role of Notch signaling in regulating trophectoderm-specific expression of Cdx2 in cooperation with TEAD4.
Endothelial cells require related transcription enhancer factor-1 for cell-cell connections through the induction of gap junction proteins.
Li et al., Beijing, China. In Arterioscler Thromb Vasc Biol, 2012
endothelial-specific RTEF-1 overexpressing mice had enhanced angiogenic sprouting and vascular structure remodeling, resulting in the formation of a denser and more highly interconnected superficial capillary plexus
Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes.
Hong et al., Singapore, Singapore. In Structure, 2012
Vgll1 interacts with TEAD4 in a manner similar to the transcription coactivators, as well as oncogenes YAP and TAZ, despite having a varied primary sequence. Vgll1 has the potential to promote cancer progression.
Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment.
Paul et al., Kansas City, United States. In Proc Natl Acad Sci U S A, 2012
Data suggest that altered subcellular localization of TEAD4 in blastomeres dictates first mammalian cell fate specification.
Transcription factor TEAD4 regulates expression of myogenin and the unfolded protein response genes during C2C12 cell differentiation.
Davidson et al., Illkirch-Graffenstaden, France. In Cell Death Differ, 2012
TEAD factors directly induce Myogenin, CDKN1A and Caveolin 3 expression to promote myoblast differentiation.
Related transcriptional enhancer factor 1 increases endothelial-dependent microvascular relaxation and proliferation.
Li et al., Boston, United States. In J Vasc Res, 2011
RTEF-1 plays an important role in FGFR1- stimulated vasodilatation.
The role of transcription enhancer factors in cardiovascular biology.
Li et al., Boston, United States. In Trends Cardiovasc Med, 2011
Among the TEF family, TEF-1, RTEF-1, and DTEF-1 are critical regulators of cardiac and smooth muscle-specific genes during cardiovascular development and cardiac disorders including cardiac hypertrophy.
Mechanisms of trophectoderm fate specification in preimplantation mouse development.
Sasaki, Kōbe, Japan. In Dev Growth Differ, 2010
TE development is regulated by a transcription factor cascade, the core transcription factors of which are Tead4 and Cdx2.
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