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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Nuclear receptor subfamily 4, group A, member 3

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: CAN, Btk, V1a, ACID, Src
Papers using Tec antibodies
Pacemaker endocarditis due to Propionibacterium acnes
Tselepides Anastasios et al., In Environmental Health Perspectives, 2002
... Total organic carbon and nitrogen concentrations were determined using a CHN 2400 analyzer (PerkinElmer, Waltham, MA, USA) ( ...
A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
Farrar William L et al., In Molecular Cancer, 1999
... used: Anti-human IL-6 antibody (R&D Systems, Minneapolis, MN), PI3K inhibitor LY294002 (Cell Signaling, Danvers, MA), Tec Kinase inhibitor LFM-A13 (Tocris, Ellisville, MO), MEK inhibitor ...
Papers on Tec
Na(+) /Ca(2+) exchanger-heterozygote knockout mice display increased relaxation in gastric fundus and accelerated gastric transit in vivo.
Takeuchi et al., Ōsaka, Japan. In Neurogastroenterol Motil, Feb 2016
The magnitude of NOR-1- and PACAP-induced relaxations in NCX1 HET and NCX2 HET was similar to that of WT.
Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1.
Graziani et al., Novara, Italy. In Sci Transl Med, Feb 2016
We show that down-regulation of DGKα activity in SAP-deficient T cells restores diacylglycerol signaling at the immune synapse and rescues RICD via induction of the proapoptotic proteins NUR77 and NOR1.
MicroRNA-199a-5p inhibits VEGF-induced tumorigenesis through targeting oxidored-nitro domain-containing protein 1 in human HepG2 cells.
Nie et al., Changsha, China. In Oncol Rep, Feb 2016
Oxidored-nitro domain-containing protein 1 (NOR1), a nitroreductase, was identified as a downstream target gene of miR-199a-5p, and upregulation of NOR1 proved critical for the inhibition of VEGF-induced cell proliferation and migration in HepG2 cells by miR-199a-5p.
Human Gb3/CD77 synthase reveals specificity toward two or four different acceptors depending on amino acid at position 211, creating P(k), P1 and NOR blood group antigens.
Czerwinski et al., Wrocław, Poland. In Biochem Biophys Res Commun, Feb 2016
Recently, it was shown that c.631C > G mutation in A4GALT, which causes p.Q211E substitution in the open reading frame of the enzyme, broadens the enzyme specificity, making it able also to synthesize Gal(α1-4)GalNAc moiety, which constitutes the defining terminal disaccharide of the NOR antigen (carried by two glycosphingolipids: NOR1 and NOR2).
The Startling Properties of Fibroblast Growth Factor 2: How to Exit Mammalian Cells without a Signal Peptide at Hand.
Nickel et al., Heidelberg, Germany. In J Biol Chem, Dec 2015
This includes the integral membrane protein ATP1A1, the phosphoinositide phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2), and Tec kinase, as well as membrane-proximal heparan sulfate proteoglycans on cell surfaces.
Evans et al., In J Ayub Med Coll Abbottabad, Jul 2015
Issues relating to the principles and processes used in mapping minor curriculum themes were explored, and the costs and benefits were identified.
Recommendations for laparoscopic liver resection: a report from the second international consensus conference held in Morioka.
Strasberg et al., São Paulo, Brazil. In Ann Surg, Apr 2015
The jury concluded that MINOR LLRs had become standard practice (IDEAL 3) and that MAJOR liver resections were still innovative procedures in the exploration phase (IDEAL 2b).
Total proximal interphalangeal joint arthroplasty for osteoarthritis versus rheumatoid arthritis--a systematic review.
Chakrabarti et al., London, United Kingdom. In Hand Surg, 2014
The study quality was assessed using the Methodological Index for Non-Randomised Studies (MINOR).
The nuclear orphan receptor NR4A1 and NR4A3 as tumor suppressors in hematologic neoplasms.
Deutsch et al., Graz, Austria. In Curr Drug Targets, 2014
NR4A1 (Nur77) belongs together with NR4A2 (Nurr1) and NR4A3 (NOR-1) to the nuclear orphan receptors of the NR4A-family.
Inducible tyrosine kinase inhibitors: a review of the patent literature (2010 - 2013).
Norman, Norman, United States. In Expert Opin Ther Pat, 2014
Itk, and the other Tec family members, Rlk and Tec, are viewed as attractive drug targets for new agents for the treatment of autoimmune and inflammatory diseases.
CD28 and ITK signals regulate autoreactive T cell trafficking.
Kang et al., Worcester, United States. In Nat Med, 2013
Concurrent ablation of the CD28-activated Tec family kinase ITK does not block spontaneous T cell activation but instead causes self-reactive Ctla4(-/-) T cells to accumulate in secondary lymphoid organs.
Dual function of Pin1 in NR4A nuclear receptor activation: enhanced activity of NR4As and increased Nur77 protein stability.
de Vries et al., Amsterdam, Netherlands. In Biochim Biophys Acta, 2012
Pin1 enhances the transcriptional activity of all three NR4A nuclear receptors and increases protein stability of Nur77 through inhibition of its ubiquitination.
The TFG-TEC fusion gene created by the t(3;9) translocation in human extraskeletal myxoid chondrosarcomas encodes a more potent transcriptional activator than TEC.
Kim et al., Seoul, South Korea. In Carcinogenesis, 2012
results suggest that the oncogenic effect of the t(3;9) translocation may be due to the TFG-TEC chimeric protein and that fusion of the TFG (NTD) to the TEC protein produces a gain-of-function chimeric product
NR4A3 rearrangement reliably distinguishes between the clinicopathologically overlapping entities myoepithelial carcinoma of soft tissue and cellular extraskeletal myxoid chondrosarcoma.
Mentzel et al., Nijmegen, Netherlands. In Virchows Arch, 2012
The pathognomic rearrangement of NR4A3 is a useful diagnostic feature in identifying cellular extraskeletal myxoid chondrosarcomas.
Expression and regulation of chemerin during rat pregnancy.
Caminos et al., Bogotá, Colombia. In Placenta, 2012
serum levels decreased significantly as gestation progressed
The nuclear receptor, Nor-1, markedly increases type II oxidative muscle fibers and resistance to fatigue.
Muscat et al., Brisbane, Australia. In Mol Endocrinol, 2012
Nor-1 expression in skeletal muscle significantly improved glucose tolerance, oxygen consumption, and endurance/fatigue resistance, consistent with the acquisition of a more oxidative muscle phenotype.
Bruton and Tec: new links in osteoimmunology.
Xing et al., Rochester, United States. In Cell Metab, 2008
A new study by Shinohara et al. (2008) shows that protein phosphorylation by the tyrosine kinases Bruton and Tec links immunity and bone as well as two signaling pathways in precursors of osteoclasts, the cells that degrade bone.
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.
Takayanagi et al., Sendai, Japan. In Cell, 2008
Study reports that mice lacking the tyrosine kinases Btk and Tec show severe osteopetrosis caused by a defect in bone resorption.
Requirements for selection of conventional and innate T lymphocyte lineages.
Schwartzberg et al., Bethesda, United States. In Immunity, 2007
Mice deficient in the Tec kinase Itk develop a large population of CD8(+) T cells with properties, including expression of memory markers, rapid production of cytokines, and dependence on Interleukin-15, resembling NKT and other innate T cell lineages.
Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia.
Conneely et al., Houston, United States. In Nat Med, 2007
Simultaneous deletion of Nr4a3 and Nr4a1 results in acute myeloid leukemia.
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