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T cell receptor beta locus

T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Several V segments and one J segment of the beta locus are known to be incapable of encoding a protein and are considered pseudogenes. The beta locus also includes eight trypsinogen genes, three of which encode functional proteins and five of which are pseudogenes. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, POLYMERASE, HAD, ACID, CD8
Papers on TCRB
Kinetics of the Interaction between BAL29880 and LK157 and the CHE-1 Class C β-lactamase.
Frère et al., Liège, Belgium. In Antimicrob Agents Chemother, Feb 2016
UNASSIGNED: The chromosome-encoded class C CHE-1 β-lactamase produced by Enterobacter cloacae exhibits a lower sensitivity to avibactam than the P99 enzyme from which it derives by a 6-residue deletion in the H-10 helix.
High-throughput pairing of T cell receptor α and β sequences.
Robins et al., Seattle, United States. In Sci Transl Med, Sep 2015
Recently, high-throughput immunosequencing methods have been developed to profile the TCR α (TCRA) and TCR β (TCRB) repertoires.
Clonal rearrangements and Malignant Clones in Peripheral T-cell Lymphoma.
Sudarikov et al., Moscow, Russia. In Acta Naturae, Jul 2015
Rearranged TCRG and TCRB gene fragments were PCR-amplified according to the BIOMED-2 protocol and analyzed by capillary electrophoresis on ABI PRISM 3130 (Applied Biosystems).
Common clonal origin of central and resident memory T cells following skin immunization.
Kupper et al., Boston, United States. In Nat Med, Jun 2015
We then analyzed antigen-activated T cells from different tissues using high-throughput sequencing (HTS) of the gene encoding the T cell receptor (TCR) β-chain (Trb, also known as Tcrb) using CDR3 sequences to simultaneously track thousands of unique T cells.
Detection and Tracking of NY-ESO-1-Specific CD8+ T Cells by High-Throughput T Cell Receptor β (TCRB) Gene Rearrangements Sequencing in a Peptide-Vaccinated Patient.
Kakimi et al., Tokyo, Japan. In Plos One, 2014
Using well-characterized clinical samples from a high responder patient (TK-f01) in an NY-ESO-1f peptide vaccine study, we performed high-throughput T cell receptor β-chain (TCRB) gene next generation sequencing (NGS) to monitor the frequency of NY-ESO-1-specific CD8+ T cells.
Spatial Regulation of V-(D)J Recombination at Antigen Receptor Loci.
Busslinger et al., Vienna, Austria. In Adv Immunol, 2014
V(D)J recombination takes place in the 3' proximal domain containing the D, J, and C gene segments, whereas 31 (Tcrb) to 200 (Igh) V genes are spread over a large region of 0.67 (Tcrb) to 3 (Igk) megabase pairs.
Discovering Che-1/AATF: a new attractive target for cancer therapy.
Fanciulli et al., Roma, Italy. In Front Genet, 2014
The transcriptional cofactor Che-1/AATF is currently emerging as an important component of the DNA damage response (DDR) machinery, the complex signaling network that maintains genome integrity and prevents tumorigenesis.
Regulation of Tcrb Gene Assembly by Genetic, Epigenetic, and Topological Mechanisms.
Oltz et al., Saint Louis, United States. In Adv Immunol, 2014
This chapter focuses on the cross talk between these mechanisms at the T cell receptor beta (Tcrb) locus, and how they sculpt a diverse TCRβ repertoire while maintaining monospecificity of this antigen receptor on each mature T lymphocyte.
Gene expression profiling and inhibition of adipose tissue accumulation of G. bimaculatus extract in rats on high fat diet.
Park et al., South Korea. In Lipids Health Dis, 2014
Compared to the control, the GB treated rat group (treated at a dose of 100 and 200 mg/kg), had 190 up-regulated genes including Gpm6a (glycoprotein m6a), Tmem14a (transmembrane protein 14A) and Fasin (fatty acid synthase), with down-regulated 235 genes including Cc121b (chemokine ligand 21b), Glycan1 (glycosylation dependent cell adhesion moleule, Serpinb1a (serine proteinase inhibitor) and Tcrb (T-cell receptor beta chain).
Effect of granulocyte colony-stimulating factor mobilization on the expression patterns, clonality and signal transduction of TRAV and TRBV repertoire.
Liu et al., Guangzhou, China. In Immunobiology, 2012
Data show that of granulocyte colony-stimulating factor (G-CSF) mobilization had an effect on the expression patterns, clonality signal transduction of T cell receptors TRAV and TRBV repertoire of alphabeta(+) T cells.
Illegitimate V(D)J recombination involving nonantigen receptor loci in lymphoid malignancy.
Aplan et al., Bethesda, United States. In Genes Chromosomes Cancer, 2012
V(D)J recombination of antigen receptor loci (IGH, IGK, IGL, TCRA, TCRB, TCRG, and TCRD) is an essential mechanism that confers enormous diversity to the mammalian immune system.
The impact of a large and frequent deletion in the human TCR β locus on antiviral immunity.
Burrows et al., Brisbane, Australia. In J Immunol, 2012
in the size of the TRBV repertoire of the TCR beta-chain gene clearly contributes toward interindividual variability in immune responses
DNA double-strand breaks relieve USF-mediated repression of Dβ2 germline transcription in developing thymocytes.
Sikes et al., Raleigh, United States. In J Immunol, 2012
A mechanism is suggested by which variable chain V(D)J recombination may feed back to regulate local transgenic Dbeta2 recombinational accessibility during thymocyte development.
Disparate degrees of hypervariable loop flexibility control T-cell receptor cross-reactivity, specificity, and binding mechanism.
Baker et al., United States. In J Mol Biol, 2012
analysis of hypervariable loop flexibility control T-cell receptor cross-reactivity, specificity, and binding mechanism
Genetic and epigenetic regulation of Tcrb gene assembly.
Oltz et al., Raleigh, United States. In Curr Top Microbiol Immunol, 2011
This chapter describes our current understanding of the cross-talk between key genetic elements and epigenetic programs during recombination of the Tcrb locus in developing T cells, how each contributes to the regulation of chromatin accessibility at individual DNA targets for recombination, and potential mechanisms that coordinate their actions.
Mitochondria as a sequestration site for incomplete TCRβ peptides: the TCRβ transmembrane domain is a sufficient mitochondrial targeting signal.
Zipori et al., Israel. In Mol Immunol, 2011
These results indicate that any given partial form of TCRbeta, that contains the transmembrane domain, is bound to be sequestered by the mitochondrion
CXCR4 acts as a costimulator during thymic beta-selection.
Ravichandran et al., Charlottesville, United States. In Nat Immunol, 2010
Passage through the beta-selection developmental checkpoint requires productive rearrangement of segments of the T cell antigen receptor-beta gene (Tcrb) and formation of a pre-TCR on the surface of CD4(-)CD8(-) thymocytes.
Initiation of allelic exclusion by stochastic interaction of Tcrb alleles with repressive nuclear compartments.
Krangel et al., Durham, United States. In Nat Immunol, 2008
Here we provide evidence for a fundamentally different basis for T cell antigen receptor-beta (Tcrb) allelic exclusion.
Regulation of Tcrb recombination ordering by c-Fos-dependent RAG deposition.
Liu et al., Shanghai, China. In Nat Immunol, 2008
Antigen receptor variable-(diversity)-joining (V(D)J) recombination at the locus encoding the T cell antigen receptor-beta (Tcrb) is ordered, with D(beta)-to-J(beta) assembly preceding V(beta)-to-DJ(beta) joining.
Essential function for SWI-SNF chromatin-remodeling complexes in the promoter-directed assembly of Tcrb genes.
Oltz et al., Nashville, United States. In Nat Immunol, 2007
Here we show that the recruitment of SWI-SNF chromatin-remodeling complexes compensated for the accessibility-control element function of a promoter but not an enhancer of the T cell receptor-beta locus (Tcrb).
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