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Protein tyrosine phosphatase, non-receptor type 2

TCPTP, T-cell protein tyrosine phosphatase, PTPN2
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: Protein-Tyrosine-Phosphatase, Pts, CAN, Insulin, ACID
Papers on TCPTP
The myeloperoxidase-derived oxidant hypothiocyanous acid inhibits protein tyrosine phosphatases via oxidation of key cysteine residues.
Davies et al., Sydney, Australia. In Free Radic Biol Med, Jan 2016
The present study extends this previous work and shows that physiologically-relevant concentrations of HOSCN alter the activity and structure of other members of the wider PTP family (including leukocyte antigen-related PTP, PTP-LAR; T-cell PTP, TC-PTP; CD45 and Src homology phosphatase-1, Shp-1) by targeting Cys residues.
Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.
Guo et al., Shanghai, China. In Bioorg Med Chem Lett, Jan 2016
Their inhibitory effects on PTP1B and other PTPs (TCPTP, SHP1, SHP2 and LAR) were evaluated.
Novel PTP1B inhibitors identified by DNA display of fragment pairs.
Winssinger et al., Genève, Switzerland. In Bioorg Med Chem Lett, Dec 2015
Screening of the focused library against PTP1B and closely related TCPTP revealed orthogonal inhibitors.
Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic.
Li et al., Jinan, China. In Bioorg Med Chem, Dec 2015
Among them, compound P7 exhibited high inhibitory activity (IC50=222nM) with moderate selectivity (8-fold) over T-cell PTPase (TCPTP) through interacting with the A, B and C binding sites of PTP1B enzyme.
Immunogenetics of juvenile idiopathic arthritis: A comprehensive review.
Prahalad et al., Salt Lake City, United States. In J Autoimmun, Nov 2015
Besides PTPN22, STAT4 and PTPN2 variants, IL2, IL2RA, IL2RB, as well as IL6 and IL6R loci also harbor variants associated with oligoarticular and RF-negative polyarticular JIA.
Generation of N-Heterocycles via Tandem Reactions of N '-(2-Alkynylbenzylidene)hydrazides.
Wu et al., Jiaxing, China. In Chem Rec, Nov 2015
Biological evaluation suggested that some compounds showed promising activities for inhibition of CDC25B, TC-PTP, HCT-116, and PTP1B.
Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling.
Tiganis et al., Indianapolis, United States. In Trends Pharmacol Sci, Oct 2015
In rodents, this has been attributed partly to the increased expression of the tyrosine phosphatases Protein Tyrosine Phosphatase 1B (PTP1B) and T cell protein tyrosine phosphatase (TCPTP), which attenuate leptin and insulin signaling.
Non-alternant non-benzenoid kekulenes: the birth of a new kekulene family.
Tobe et al., Toyonaka, Japan. In Chem Soc Rev, Oct 2015
Recently, new kekulene-related molecules, septulene, which is a non-alternant benzenoid hydrocarbon, and a tetracyclopentatetraphenylene (TCPTP) derivative belonging to non-alternant non-benzenoid hydrocarbons, were synthesized.
Role of protein tyrosine phosphatases in regulating the immune system: implications for chronic intestinal inflammation.
Scharl et al., Zürich, Switzerland. In Inflamm Bowel Dis, Mar 2015
Evidence emerges that expression levels of PTPN2, PTPN11, and PTPN22 are altered in actively inflamed intestinal tissue.
Leptin and insulin act on POMC neurons to promote the browning of white fat.
Tiganis et al., Australia. In Cell, Feb 2015
Deletion of the phosphatases PTP1B and TCPTP enhanced insulin and leptin signaling in proopiomelanocortin neurons and prevented diet-induced obesity by increasing WAT browning and energy expenditure.
Genetic Predictors of Poor Prognosis in Portuguese Patients with Juvenile Idiopathic Arthritis: Data from
Canhão et al., Lisbon, Portugal. In J Immunol Res, 2014
In univariate analysis, we found significant associations with poor prognosis for allele A of TNFA1P3/20 rs6920220, allele G of TRAF1/C5 rs3761847, and allele G of PTPN2 rs7234029.
Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease.
Naser et al., Orlando, United States. In Front Cell Infect Microbiol, 2014
This review article is focused on the impact of SNP's in PTPN2 (protein tyrosine phosphatase, non-receptor type 2) and PTPN22 (protein tyrosine phosphatase non-receptor type 22) on the development of Crohn's disease and T1D.
The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2.
Bishop et al., United States. In Nat Immunol, 2014
TRAF3 dampened interleukin 2 (IL-2) signaling by facilitating recruitment of the tyrosine phosphatase TCPTP to the IL-2 receptor complex, which resulted in dephosphorylation of the signaling molecules Jak1 and Jak3 and negative regulation of signaling via Jak and the transcription factor STAT5.
Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2.
Tiganis et al., Australia. In Cell Metab, 2014
In obese mice, hepatic PTPN2 (TCPTP) inactivation promoted lipogenesis and steatosis and insulin-STAT-5 signaling.
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis.
Thompson et al., Manchester, United Kingdom. In Nat Genet, 2013
We confirmed association of 3 known JIA risk loci (the human leukocyte antigen (HLA) region, PTPN22 and PTPN2) and identified 14 loci reaching genome-wide significance (P < 5 × 10(-8)) for the first time.
The role for protein tyrosine phosphatase nonreceptor type 2 in regulating autophagosome formation.
Rogler et al., Zürich, Switzerland. In Ann N Y Acad Sci, 2012
Genome-wide association studies have identified single nucleotide polymorphisms within the gene locus encoding protein tyrosine phosphatase nonreceptor type 2 (PTPN2) as a risk factor for the development of chronic inflammatory diseases
Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2.
McCole, San Diego, United States. In Ann N Y Acad Sci, 2012
These data identify an important functional role for PTPN2 as a protector of the intestinal epithelial barrier and provide clues as to how PTPN2 mutations may contribute to the pathophysiology of CD.
PTPN2 is associated with Crohn's disease and its expression is regulated by NKX2-3.
Lin et al., United States. In Dis Markers, 2011
A positive correlation was observed between mRNA expression of PTPN2 and NKX2-3 in B cells and in intestinal tissues from both Crohn's disease and ulcerative colitis patients.
PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.
Brand et al., München, Germany. In Plos One, 2011
data confirm the association of PTPN2 variants with susceptibility to both Crohn's disease and ulcerative colitis, suggesting a common disease pathomechanism for these diseases
Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice.
Tiganis et al., Australia. In Plos One, 2011
these results reaffirm TCPTP's important role in lymphocyte development and indicate that the effects on morbidity, mortality, bone development and the myeloid compartment are strain-dependent.
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