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DDB1 and CUL4 associated factor 12

TCC52, WDR40A, CT-102
This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009] (from NCBI)
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Top mentioned proteins: TGF-beta, Epidermal Growth Factor, FAN, MM2, CAN
Papers on TCC52
Pediatric multicenter evaluation of the Verigene gram-negative blood culture test for rapid detection of inpatient bacteremia involving gram-negative organisms, extended-spectrum beta-lactamases, and carbapenemases.
Mortensen et al., Cincinnati, United States. In J Clin Microbiol, 2014
The Check MDR CT-102 microarray (Check Points B.V., Wageningen, Netherlands) was used as an alternative method for detecting resistance determinants.
Gene-based bio-signature patterns and cardiac allograft rejection.
Benitez et al., Baltimore, United States. In Heart Fail Clin, 2010
The informative genes represent several biologic pathways, including T-cell activation (PDCD1), T-cell migration (ITGA4), and mobilization of hematopoietic precursors (WDR40A and microRNA gene family cMIR), and steroid-responsive genes such as IL1R2, the decoy receptor for interleukin 2. The greatest value may include the ability to inform on the potential of future proclivity for rejection, allowing patients to be stratified into low, intermediate, or high risk subsets for future rejection.
Novel centrosome protein, TCC52, is a cancer-testis antigen.
He et al., Beijing, China. In Cancer Sci, 2008
TCC52, as a novel CT antigen, would be a promising candidate for cancer immunotherapy.
Gene expression profiling distinguishes a molecular signature for grade 1B mild acute cellular rejection in cardiac allograft recipients.
Kobashigawa et al., Stanford, United States. In J Heart Lung Transplant, 2007
Of the classifier's 11 informative genes, expression of MIR and WDR40 showed statistically significant increases for both Grade 1B and Grade >or=3A rejection.
Randomized prospective double-blind trial in healing chronic diabetic foot ulcers. CT-102 activated platelet supernatant, topical versus placebo.
Webster et al., Pittsburgh, United States. In Diabetes Care, 1992
OBJECTIVE: To assess the efficacy of topically applied CT-102 APST for treating diabetic neurotrophic foot ulcers.
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