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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: titin, CAN, teneurin-1, HAD, V1a
Papers on TCAP
Role of the teneurins, teneurin C-terminal associated peptides (TCAP) in reproduction: clinical perspectives.
Pavlović et al., In Horm Mol Biol Clin Investig, Dec 2015
Structurally complex, these genes possess a sequence in their terminal exon that encodes for a bioactive peptide sequence termed the 'teneurin C-terminal associated peptide' (TCAP).
Manipulation of sarcoplasmic reticulum Ca(2+) release in heart failure through mechanical intervention.
Terracciano et al., Philadelphia, United States. In J Physiol, Sep 2015
While there are multiple molecular pathways which underpin t-tubule regulation, Telethonin (Tcap) appears to be important in regulating the effect of altered loading on the t-tubule system.
A prospective study on the immunophenotypic characterization of limb girdle muscular dystrophies 2 in India.
Preethish-Kumar et al., Bengaluru, India. In Neurol India, Jul 2015
LGMD2G was present in 8 patients (3.25%), and LGMD2H and 2J in 2 cases each, respectively.
Clinical applications of next-generation sequencing-based gene panel in patients with muscular dystrophy: Korean experience.
Chae et al., Seoul, South Korea. In Clin Genet, Jul 2015
LGMD2B was the most common LGMD type, followed by LGMD1B, LGMD2A, and LGMD2G.
Characterization of the teneurin C-terminal associated peptide (TCAP) in the vase tunicate, Ciona intestinalis: A novel peptide system associated with energy metabolism and reproduction.
Lovejoy et al., Toronto, Canada. In Gen Comp Endocrinol, Jun 2015
The teneurin C-terminal associated peptides (TCAP) are a family of highly conserved peptide hormones found in most metazoans.
Conserved expression of truncated telethonin in a patient with limb-girdle muscular dystrophy 2G.
Straub et al., Newcastle upon Tyne, United Kingdom. In Neuromuscul Disord, Apr 2015
Limb-girdle muscular dystrophy 2G is caused by mutations in the TCAP gene that encodes for telethonin.
Interplay of Coil-Globule Transition and Surface Adsorption of a Lattice HP Protein Model.
Wang et al., Hangzhou, China. In J Phys Chem B, 2015
We find that the critical adsorption phenomenon can always be observed; however, the critical adsorption temperature TCAP is influenced by the attractive H-H interactions in some cases.
A phase I/II trial of epirubicin and docetaxel in locally advanced breast cancer (LABC) on 2-weekly or 3-weekly schedules: NCIC CTG MA.22.
Parissenti et al., Toronto, Canada. In Springerplus, 2014
Pre-treatment expression of several genes was associated with clinical response, including those within a likely amplicon at 17q12 (ERBB2, TCAP, GSDMB, and PNMT).
Ancient interaction between the teneurin C-terminal associated peptides (TCAP) and latrophilin ligand-receptor coupling: a role in behavior.
Lovejoy et al., Toronto, Canada. In Front Neurosci, 2014
Synthetic TCAP-1 interacts with LPHN, with an association with β-dystroglycan, to induce a tissue-dependent signal cascade to modulate cytoskeletal dynamics.
Induction of Ankrd1 in Dilated Cardiomyopathy Correlates with the Heart Failure Progression.
Labeit et al., Mannheim, Germany. In Biomed Res Int, 2014
Expression patterns of 8 mechanoptotic machinery-associated titin ligands (ANKRD1, ANKRD2, TRIM63, TRIM55, NBR1, MLP, FHL2, and TCAP) were quantitated in endomyocardial biopsies from 25 patients with advanced IDCM.
OBSCN Mutations Associated with Dilated Cardiomyopathy and Haploinsufficiency.
Knöll et al., London, United Kingdom. In Plos One, 2014
Also identified were 6 truncating mutations in TTN, 3 mutations in MYH7, 2 in DSP and one each in TNNC1, TNNI3, MYOM1, VCL, GLA, PLB, TCAP, PKP2 and LAMA4.
Genetic basis of limb-girdle muscular dystrophies: the 2014 update.
Savarese et al., Napoli, Italy. In Acta Myol, 2014
The autosomal recessive forms (LGMD2) are: LGMD2A (calpain 3), LGMD2B (dysferlin), LGMD2C (γ sarcoglycan), LGMD2D (α sarcoglycan), LGMD2E (β sarcoglycan), LGMD2F (δ sarcoglycan), LGMD2G (telethonin), LGMD2H (TRIM32), LGMD2I (FKRP), LGMD2J (titin), LGMD2K (POMT1), LGMD2L (anoctamin 5), LGMD2M (fukutin), LGMD2N (POMT2), LGMD2O (POMTnG1), LGMD2P (dystroglycan), LGMD2Q (plectin), LGMD2R (desmin), LGMD2S (TRAPPC11), LGMD2T (GMPPB), LGMD2U (ISPD), LGMD2V (Glucosidase, alpha ), LGMD2W (PINCH2).
Teneurin C-terminal associated peptides (TCAP): modulators of corticotropin-releasing factor (CRF) physiology and behavior.
Lovejoy et al., Toronto, Canada. In Front Neurosci, 2012
The existence of the teneurin C-terminal associated peptides (TCAP) was reported in 2004 after screening a rainbow trout hypothalamic cDNA for corticotropin-releasing factor (CRF)-related homologs.
Modulation of neuroplastic changes and corticotropin-releasing factor-associated behavior by a phylogenetically ancient and conserved peptide family.
Lovejoy et al., Toronto, Canada. In Gen Comp Endocrinol, 2012
TCAP-1 is a potent regulator of CRF-associated physiology and behavior and may play a significant role in the regulation of cell-to-cell communication and neuroplasticity in neurons.
A study of FHL1, BAG3, MATR3, PTRF and TCAP in Australian muscular dystrophy patients.
Clarke et al., Sydney, Australia. In Neuromuscul Disord, 2011
This study identified no pathogenic mutations in BAG3, MATR3, PTRF or TCAP in Australian muscular dystrophy.
Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.
Chien et al., London, United Kingdom. In Circ Res, 2011
Telethonin knockout mice develop heart failure following biomechanical stress, owing at least in part to apoptosis of cardiomyocytes, an effect that may also play a role in human heart failure.
Transcriptional analysis of the titin cap gene.
Davie et al., Carbondale, United States. In Mol Genet Genomics, 2011
Whereas both promotor E boxes in Tcap are required for full activation by MyoD or myogenin in NIH3T3 cells, the promoter proximal E box has a greater contribution to activation in C2C12 cells and to activation by MyoD in NIH3T3 cells.
Decreased myocardial expression of dystrophin and titin mRNA and protein in dilated cardiomyopathy: possibly an adverse effect of TNF-alpha.
Talwar et al., Chandīgarh, India. In J Clin Immunol, 2010
reduced expression of dystrophin and titin is associated with the pathophysiology of dilated cardiomyopathy, and TNF-alpha may modulate the expression of these proteins via NF-kappaB pathway.
Depletion of zebrafish Tcap leads to muscular dystrophy via disrupting sarcomere-membrane interaction, not sarcomere assembly.
Xu et al., Rochester, United States. In Hum Mol Genet, 2009
Genetic studies of tcap in zebrafish suggested that pathogenesis in LGMD2G is due to a disruption of sarcomere-T-tubular interaction, but not of sarcomere assembly per se.
The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy.
Chien et al., San Diego, United States. In Cell, 2003
MLP interacts with and colocalizes with telethonin (T-cap), a titin interacting protein.
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