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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

T-box 2

Tbx2, Tbx2b
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Tbx3, CAN, HAD, p16, p21
Papers using Tbx2 antibodies
Beta and gamma oscillations in the olfactory system of the urethane-anesthetized rat
Yoshihara Yoshihiro et al., In Neural Systems & Circuits, 2002
... Zonal expression of gapVenus in the primary olfactory pathway of Tbx2.6gV transgenic mouse (line #120) ...
Papers on Tbx2
TBX2 represses PTEN in rhabdomyosarcoma and skeletal muscle.
Davie et al., Carbondale, United States. In Oncogene, Jan 2016
TBX2, a T-box family member, is highly upregulated in tumor cells of both major RMS subtypes where it functions as an oncogene.
Rare copy number variants implicated in posterior urethral valves.
Mills et al., Bethesda, United States. In Am J Med Genet A, Jan 2016
Other interesting CNVs, each detected in a single PUV case included: a deletion of PIK3R3 and TSPAN1, duplication/triplication in FGF12, duplication of FAT1-a gene essential for normal growth and development, a large deletion (>2 Mb) on chromosome 17q that involves TBX2 and TBX4, and large duplications (>1 Mb) on chromosomes 3q and 6q.
Microphthalmia-associated transcription factor/T-box factor-2 axis acts through Cyclin D1 to regulate melanocyte proliferation.
Hou et al., Wenzhou, China. In Cell Prolif, Dec 2015
Here, we have analysed the role of microphthalmia-associated transcription factor MITF and its direct target, T-box factor TBX2, in regulating proliferation of mammalian neural crest-derived melanocytes.
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
Chambers et al., Tokyo, Japan. In Nat Genet, Nov 2015
The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function.
T-box 2 expression predicts poor prognosis in gastric cancer.
Zhao et al., Jinan, China. In Oncol Lett, Sep 2015
UNASSIGNED: T-Box 2 (TBX2) plays a critical role in embryonic development.
Characteristic expression of MSX1, MSX2, TBX2 and ENTPD1 in dental pulp cells.
Kato et al., Hiroshima, Japan. In Biomed Rep, Jul 2015
The msh homeobox 1, msh homeobox 2, T-box 2 and ectonucleoside triphosphate diphosphohydrolase 1 mRNA levels in DPCs were higher than that of the levels identified in the following cell types: MSCs derived from bone marrow, synovium and adipose tissue; and in cells such as FBs, osteoblasts, adipocytes and chondrocytes.
Genome-wide Analysis of Body Proportion Classifies Height-Associated Variants by Mechanism of Action and Implicates Genes Important for Skeletal Development.
Hirschhorn et al., Boston, United States. In Am J Hum Genet, Jun 2015
Six regions reached genome-wide significance (p < 5 × 10(-8)) for association with SHR and overlapped biological candidate genes, including TBX2 and IGFBP3.
T-box transcription factors in cancer biology.
Prince et al., Cape Town, South Africa. In Biochim Biophys Acta, 2014
Of these the best characterised is TBX2, whose expression is upregulated in cancers including breast, pancreatic, ovarian, liver, endometrial adenocarcinoma, glioblastomas, gastric, uterine cervical and melanoma.
Putative Breast Cancer Driver Mutations in TBX3 Cause Impaired Transcriptional Repression.
Pflugfelder et al., Mainz, Germany. In Front Oncol, 2014
The closely related T-box transcription factors TBX2 and TBX3 are frequently overexpressed in melanoma and various types of human cancers, in particular, breast cancer.
The T-box transcription factors TBX2 and TBX3 in mammary gland development and breast cancer.
Papaioannou et al., New York City, United States. In J Mammary Gland Biol Neoplasia, 2013
TBX2 and TBX3, closely related members of the T-box family of transcription factor genes, are expressed in mammary tissue in both humans and mice.
Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation.
Christoffels et al., Hannover, Germany. In Cell Mol Life Sci, 2012
Tbx2 and Tbx3 trigger development of the endocardial cushions through a regulatory feed-forward loop with Bmp2, thus providing a mechanism for the co-localization and coordination of these important processes in heart development.
Dynamic expression of Tbx2 subfamily genes in development of the mouse reproductive system.
Papaioannou et al., New York City, United States. In Dev Dyn, 2012
This study lays the foundation for investigation of functional requirements for Tbx2 subfamily genes in development of the mammalian reproductive system.
Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence.
Bischof et al., Paris, France. In Embo J, 2012
PML and TBX2 act in an autoregulatory loop to control the effective execution of the senescence program.
Ectopic retinoic acid signaling affects outflow tract cushion development through suppression of the myocardial Tbx2-Tgfβ2 pathway.
Saga et al., Mishima, Japan. In Development, 2012
The Tbx2-Tgfbeta2 cascade is one of the key pathways involved in inducing the transposition of the great arteries phenotype.
Dynamic expression of Tbx2 and Tbx3 in developing mouse pancreas.
Papaioannou et al., New York City, United States. In Gene Expr Patterns, 2011
Tbx2 and Tbx3 are both expressed in the pancreatic mesenchyme throughout development
A de novo 3.54 Mb deletion of 17q22-q23.1 associated with hydrocephalus: a case report and review of literature.
Bhandari et al., New Haven, United States. In Am J Med Genet A, 2011
Review of reported cases with genomic findings noted one case with proximal deletion involving the NOG gene and a case series with distal recurrent microdeletions involving the TBX2 and TBX4 genes.
TBX2 and TBX3: the special value for anticancer drug targets.
He et al., Guangzhou, China. In Biochim Biophys Acta, 2010
TBX2 and TBX3 are members of the T-box family of transcription factors, which are implicated in embryonic development.
omb and circumstance.
Pflugfelder, Mainz, Germany. In J Neurogenet, 2008
The orthologous genes, TBX2 and TBX3, are found overexpressed or amplified in an increasing number of human cancers, emphasizing the importance of Tbx genes also in postdevelopmental processes.
Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression.
Watabe et al., Springfield, United States. In Nat Med, 2006
Our results indicate that the cancer cells expressing KAI1 attach to vascular endothelial cells through direct interaction between KAI1 and DARC, and that this interaction leads to inhibition of tumor cell proliferation and induction of senescence by modulating the expression of TBX2 and p21.
Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.
van Lohuizen et al., Amsterdam, Netherlands. In Nat Genet, 2000
We identified the T-box member TBX2 as a potent immortalizing gene that acts by downregulating Cdkn2a (p19(ARF)).
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