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Solute carrier family 26, member 8

TAT1, tat-I, SLC26A8
This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010] (from NCBI)
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Top mentioned proteins: ACID, CAN, V1a, HAD, DTDST
Papers on TAT1
Yeast Cyc8p and Tup1p proteins function as coactivators for transcription of Stp1/2p-dependent amino acid transporter genes.
Mukai et al., Nagahama, Japan. In Biochem Biophys Res Commun, Jan 2016
Herein, we found tryptophan transporter genes, TAT1 and TAT2, that, when overexpressed, suppressed the slow growth of Δcyc8.
Uncovering the clinical utility of miR-143, miR-145 and miR-224 for predicting the survival of bladder cancer patients following treatment.
Scorilas et al., Athens, Greece. In Carcinogenesis, May 2015
Important associations with disease aggressiveness were observed for all three microRNAs; elevated levels were observed in tumors of higher stage and grade, as well as in 'high-risk' TaT1 patients.
Maternal Factors Are Associated with the Expression of Placental Genes Involved in Amino Acid Metabolism and Transport.
Cleal et al., Southampton, United Kingdom. In Plos One, 2014
Placental mRNA expression of TAT1 (p = 0.01), ASCT1 (p = 0.03), mitochondrial branched chain aminotransferase (p = 0.02) and glutamine synthetase (p = 0.05) was positively associated with maternal strenuous exercise.
A Multi-Breed Genome-Wide Association Analysis for Canine Hypothyroidism Identifies a Shared Major Risk Locus on CFA12.
Rosengren Pielberg et al., Uppsala, Sweden. In Plos One, 2014
This breed-shared risk haplotype includes three genes (LHFPL5, SRPK1 and SLC26A8) and does not extend to the dog leukocyte antigen (DLA) class II gene cluster located in the vicinity.
Molecular cloning and characterization of tyrosine aminotransferase and hydroxyphenylpyruvate reductase, and rosmarinic acid accumulation in Scutellaria baicalensis.
Park et al., In Nat Prod Commun, 2014
cDNA clones encoding tyrosine aminotransferase (TAT1 and 2) and hydroxyphenylpyruvate reductase (HPPR) have been isolated from Scutellaria baicalensis.
Functional interaction of the cystic fibrosis transmembrane conductance regulator with members of the SLC26 family of anion transporters (SLC26A8 and SLC26A9): physiological and pathophysiological relevance.
Touré et al., Paris, France. In Int J Biochem Cell Biol, 2014
In this review, we will focus on the functional interaction of SLC26A8 and SLC26A9 with the CFTR channel.
The SLC26 gene family of anion transporters and channels.
Sharma et al., Boston, United States. In Mol Aspects Med, 2013
Additional disease phenotypes evident only in mouse knockout models include oxalate urolithiasis for Slc26a6 and Slc26a1, non-syndromic deafness for Slc26a5, gastric hypochlorhydria for Slc26a7 and Slc26a9, distal renal tubular acidosis for Slc26a7, and male infertility for Slc26a8.
The SLC16 gene family - structure, role and regulation in health and disease.
Halestrap, Bristol, United Kingdom. In Mol Aspects Med, 2013
SLC16A2 encodes a high affinity thyroid hormone transporter (MCT8) and SLC16A10 an aromatic amino acid transporter (TAT1).
Monocarboxylate transporter 10 functions as a thyroid hormone transporter in chondrocytes.
Ozono et al., Suita, Japan. In Endocrinology, 2012
The results suggest that Mct10 functions as a thyroid hormone transporter in chondrocytes and can explain at least in part why Allan-Herndon-Dudley syndrome patients do not exhibit significant growth impairment.
Developmental and cell-specific expression of thyroid hormone transporters in the mouse cochlea.
Forrest et al., Bethesda, United States. In Endocrinology, 2011
expression of candidate thyroid hormone transporters Lat1, Mct8, Mct10, and Oatp1c1 in mouse cochlear development
Septins at the annulus of mammalian sperm.
Gacon et al., Paris, France. In Biol Chem, 2011
A septin complex is assembled early in spermiogenesis with the cochaperone DNAJB13 and, in mature sperm, associates with Testis Anion Transporter 1; SLC26A8 (Tat1), a transmembrane protein of the SLC26 family.
Absence of annulus in human asthenozoospermia: case report.
Touré et al., Paris, France. In Hum Reprod, 2009
structural defects in sperm are not caused by abnormal transcription or point mutations of the TAT1 and SEPT4 genes; however, although both proteins are expressed, they are not properly localized at sperm annulus
The SLC16 monocaboxylate transporter family.
Christian et al., Oxford, United Kingdom. In Xenobiotica, 2008
2. Of the other members of the MCT family, MCT8 (a thyroid hormone transporter) and TAT1 (an aromatic amino acid transporter) have been characterized more recently, and their physiological roles are reviewed herein.
Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry.
Xue et al., Boulder, United States. In Science, 2008
We report that the Caenorhabditis elegans P-type adenosine triphosphatase homolog, TAT-1, is critical for maintaining cell surface asymmetry of phosphatidylserine (PS).
The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse.
Gacon et al., Paris, France. In Hum Mol Genet, 2007
Tat1 (Slc26A8) is a critical component of the sperm annulus that is essential for proper sperm tail differentiation and motility
Recycling of aromatic amino acids via TAT1 allows efflux of neutral amino acids via LAT2-4F2hc exchanger.
Verrey et al., Zürich, Switzerland. In Pflugers Arch, 2007
the aromatic amino acid diffusion pathway TAT1 can control neutral amino acid efflux via neighboring exchanger LAT2-4F2hc, by recycling its aromatic influx substrates
HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kappa B-like factor.
Nabel et al., Ann Arbor, United States. In Nature, 1988
In particular, HTLV-I infected T cells synthesize interleukin-2 receptor alpha (IL-2R alpha) chain, which is probably induced through the mediation of the tat-I gene product of the virus.
Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-I.
Greene et al., Durham, United States. In Science, 1988
Phytohemagglutinin (PHA), a mitogenic lectin; phorbol 12-myristic 13-acetate, a tumor promoter; ionomycin, a calcium ionophore; and tat-1, the trans-activator protein from the human T cell leukemia/lymphoma virus type I (HTLV-I) each stimulated the HIV-1 LTR.
Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I.
Leonard et al., In Cell, 1987
Deletions to -267 and -265 were active only in HTLV-I-transformed T cells, but their activity in Jurkat cells was restored by cotransfection of a construct expressing the HTLV-I transactivator protein (tat-I).
In Science, 1987
In the Technical Comment "Trans-activator gene of HTLV-II: Interpretation" by W. C. Greene et al. (27 Feb., p. 1073), the third-from-the-last sentence should have read, "In addition, using Jurkat or other T-cell lines, Inoue and colleagues (2) and Maruyama et al. (3) have described activation of both the IL-2 receptor and IL-2 genes by the tat-I gene isolated from HTLV-I, which shares similar structural and functional properties with the tat-II gene."
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