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Taspase, threonine aspartase, 1

Taspase1, TASP1, threonine aspartase, TASPI
This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Asparaginase, MLL, CAN, ACID, Inactive
Papers using Taspase1 antibodies
The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activity.
Bogyo Matthew, In PLoS ONE, 2007
... (directed against the N-terminus of Taspase1, sc-85945; Santa Cruz Biotechnology, Heidelberg, Germany) ...
Papers on Taspase1
Cleaving for growth: threonine aspartase 1-a protease relevant for development and disease.
Wünsch et al., Mainz, Germany. In Faseb J, Dec 2015
The highly conserved protease threonine aspartase 1 is a member of such developmental proteases and critically involved in the regulation of complex processes, including segmental identity, head morphogenesis, spermatogenesis, and proliferation.
Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription.
Hsieh et al., In J Clin Invest, Apr 2015
Here, we demonstrate that, during mouse head formation, taspase1-mediated (TASP1-mediated) cleavage of the general transcription factor TFIIA ensures proper coordination of rapid cell proliferation and morphogenesis by maintaining limited transcription of the negative cell cycle regulators p16Ink4a and p19Arf from the Cdkn2a locus.
Integrative Analysis of the Developing Postnatal Mouse Heart Transcriptome.
Lee et al., Hong Kong, Hong Kong. In Plos One, 2014
In addition, Regulator Effects network analysis suggested that TASP1, TOB1, C1orf61, AIF1, ROCK1, TFF2 and miR503-5p may be acting on the cardiomyocytes in 13-day-old mouse hearts to inhibit cardiomyocyte proliferation and G1/S phase transition.
Peptidyl succinimidyl peptides as taspase 1 inhibitors.
Kaiser et al., Essen, Germany. In Chembiochem, 2014
Taspase 1 is an N-terminal threonine protease implicated in leukemia and other cancers.
The importin-alpha/nucleophosmin switch controls taspase1 protease function.
Stauber et al., Mainz, Germany. In Traffic, 2011
Taspase1 appears to exploit the nuclear export activity of importin-alpha/nucleophosmin to gain transient access to the cytoplasm required to also cleave its cytoplasmic substrates.
Aptamer-based turn-on fluorescent four-branched quaternary ammonium pyrazine probe for selective thrombin detection.
Zhou et al., Wuhan, China. In Chem Commun (camb), 2011
In this thrombin detection system, the bright fluorescence of TASPI is almost eliminated by the DNA aptamer TBA (turn-off); however, in the presence of thrombin, it specifically binds to TBA by folding unrestricted TBA into an anti-parallel G-quadruplex structure and then releasing TASPI molecules, resulting in vivid and facile fluorescence recovery (turn-on).
mll ortholog containing functional domains of human MLL is expressed throughout the zebrafish lifespan and in haematopoietic tissues.
Felix et al., Philadelphia, United States. In Br J Haematol, 2011
The protein encoded by the 35-exon ORF exhibited 46·4% overall identity to human MLL and 68-100% conservation in functional domains (AT-hooks, SNL, CXXC, PHD, bromodomain, FYRN, taspase1 sites, FYRC, SET).
Cell-based analysis of structure-function activity of threonine aspartase 1.
Stauber et al., Mainz, Germany. In J Biol Chem, 2011
Cell-based analysis of structure-function activity of threonine aspartase 1.
Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis.
Hsieh et al., Saint Louis, United States. In Cancer Res, 2010
Taspase1 is overexpressed in primary human cancers, and deficiency of Taspase1 in cancer cells not only disrupts proliferation but also enhances apoptosis.
Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR.
Tone et al., Ribeirão Preto, Brazil. In J Neurooncol, 2008
The gene expression levels were significantly higher in glioblastomas than in non-neoplastic white matter in 18 out of 20 genes analyzed: P < 0.00001 for CDKN2C, CKS2, EEF1A1, EMP3, PDPN, BNIP2, CA12, CD34, CDC42EP4, PPIE, SNAI2, GDF15 and MMP23b; and NFIA (P: 0.0001), GPS1 (P: 0.0003), LAMA1 (P: 0.002), STIM1 (P: 0.006), and TASP1 (P: 0.01).
EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.
Borlak et al., Hannover, Germany. In Gastroenterology, 2008
TASP1, EPS15R, and PRPF3 expression were significantly induced in HCCs of transgenic EGF2B mice as was P2 promoter-driven HNF4alpha
Species selectivity of mixed-lineage leukemia/trithorax and HCF proteolytic maturation pathways.
Herr et al., Lausanne, Switzerland. In Mol Cell Biol, 2007
MLL is processed by a protease called taspase 1, whereas the precise mechanisms of HCF-1 maturation are unclear, although they are known to depend on a series of sequence repeats called HCF-1(PRO) repeats.
Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.
Hsieh et al., Saint Louis, United States. In Genes Dev, 2006
This paper describes the quintessential function of Taspase1 in orchestrating cell cycle progression.
Crystal structure of plant asparaginase.
Jaskolski et al., Poznań, Poland. In J Mol Biol, 2006
Detailed analysis of the active site suggests why the plant enzyme hydrolyzes asparagine and its beta-peptides but is inactive towards substrates accepted by similar Ntn-hydrolases, such as taspase1, an enzyme implicated in some human leukemias.
Uncleaved TFIIA is a substrate for taspase 1 and active in transcription.
Stunnenberg et al., Nijmegen, Netherlands. In Mol Cell Biol, 2006
Transfected taspase 1 enhances cleavage of TFIIA, and RNA interference knockdown of endogenous taspase 1 diminishes cleavage of TFIIA in vivo.
Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.
Korsmeyer et al., Boston, United States. In Cell, 2003
purification and cloning of threonine aspartase 1 responsible for cleaving MLL; RNAi-mediated knockdown of Taspase1 results in the appearance of unprocessed MLL and the loss of proper HOX gene expression
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