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Taste receptor, type 2, member 5

This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: hTAS2R16, TAS2R38, Pirh2, Glucuronosyltransferase, AGE
Papers on TAS2R5
Genetic variation in taste receptor pseudogenes provides evidence for a dynamic role in human evolution.
Drayna et al., In Bmc Evol Biol, 2013
At the TAS2R6P locus, two SNPs were found in strong linkage disequilibrium (r2 > 0.9) with variants in the functional TAS2R5 gene, which showed signatures of selection.
Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain.
Ferrer et al., Barcelona, Spain. In J Neuropathol Exp Neurol, 2013
Olfactory receptors OR2L13, OR1E1, OR2J3, OR52L1, and OR11H1 and taste receptors TAS2R5 and TAS2R50 were downregulated, but TAS2R10 and TAS2R13 were upregulated at premotor and parkinsonian stages in the frontal cortex area 8 in PD patient brains.
Different phenolic compounds activate distinct human bitter taste receptors.
De Freitas et al., Porto, Portugal. In J Agric Food Chem, 2013
(-)-Epicatechin activated three receptors, TAS2R4, TAS2R5, and TAS2R39, whereas only two receptors, TAS2R5 and TAS2R39, responded to PGG.
The expression and relaxant effect of bitter taste receptors in human bronchi.
Devillier et al., Paris, France. In Respir Res, 2012
Receptor expression analysis together with the use of selective agonists suggest a predominant role for TAS2R5, 10 and 14 in bitter taste agonist-induced relaxation.
Allelic variation in TAS2R bitter receptor genes associates with variation in sensations from and ingestive behaviors toward common bitter beverages in adults.
Duffy et al., United States. In Chem Senses, 2011
A haploblock across TAS2R3, TAS2R4, and TAS2R5 explained some variability in the bitterness of espresso coffee.
Comparison of the power between microsatellite and single-nucleotide polymorphism markers for linkage and linkage disequilibrium mapping of an electrophysiological phenotype.
Cheng et al., New York City, United States. In Bmc Genet, 2004
The SNPs rs1476640 and rs768055 are located in the FLJ40852 gene (a hypothetical protein), and SNP rs1859646 is located in the TAS2R5 gene (a taste receptor).
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