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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Transient receptor potential cation channel, subfamily C, member 4 associated protein

TAP1 protein, transient receptor potential cation channel, subfamily C, member 4 associated protein, TRPC4AP
Top mentioned proteins: TAP1, MHC, C-1, IFN-gamma, ACID
Papers on TAP1 protein
Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex.
He et al., Shanghai, China. In Hepatology, 2014
This identified 24 somatic nonsynonymous mutations in 21 genes, many of which were novel, including three novel mutations targeting the CTNNB1 (G512V) and CAPRIN2 (R968H/S969C) genes in the Wnt pathway, and genes previously shown to be involved in the ubiquitin ligase complex (SPOP, KLHL22, TRPC4AP, and RNF169).
Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample.
Craddock et al., Cardiff, United Kingdom. In Mol Psychiatry, 2013
Second, rs3818253 (P=3.88 × 10(-8), OR=1.16), an intronic SNP on chromosome 20q11.2 in the gene TRPC4AP, which lies in a high linkage disequilibrium region along with the genes GSS and MYH7B.
Localization, expression change in PRRSV infection and association analysis of the porcine TAP1 gene.
Wu et al., Guangzhou, China. In Int J Biol Sci, 2011
Subcellular localization of TAP1 by transient transfection of PK15 cells indicated that the TAP1 protein might be located in the endoplasmic reticulum (ER) in pig kidney epithelial cells (PK-15).
HMME-based PDT restores expression and function of transporter associated with antigen processing 1 (TAP1) and surface presentation of MHC class I antigen in human glioma.
Li et al., Guangzhou, China. In J Neurooncol, 2011
Furthermore, the newly synthesized TAP1 protein was capable of potentiating the activity of transporting antigen peptides.
Use of biological knowledge to inform the analysis of gene-gene interactions involved in modulating virologic failure with efavirenz-containing treatment regimens in ART-naïve ACTG clinical trials participants.
Ritchie et al., Nashville, United States. In Pac Symp Biocomput, 2010
The TAP1 protein is responsible for intracellular transport of antigen to MHC class I molecules, while ABCC9 codes for a transporter which is part of the subfamily of ABC transporters associated with multi-drug resistance.
TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling.
Riches et al., Denver, United States. In J Cell Physiol, 2010
These findings suggest that TNF-R1, TRUSS, and TRPC4 augment Ca(2+) loading of endoplasmic reticulum Ca(2+) stores in the context of m1AchR stimulation
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells.
Cole et al., United States. In Genes Dev, 2010
TRPC4AP/TRUSS binds specifically to the Myc C terminus and promotes its ubiquitination and destruction through the recognition of evolutionarily conserved domains in the Myc N terminus
The CRAL/TRIO and GOLD domain protein TAP-1 regulates RAF-1 activation.
Kornfeld et al., Saint Louis, United States. In Dev Biol, 2010
TAP-1 mRNA was expressed in many tissues, and TAP-1 protein colocalized with Ras and Raf at the cell membrane.
Mouse strains with point mutations in TAP1 and TAP2.
Fahrer et al., Canberra, Australia. In Immunol Cell Biol, 2010
TAP1 protein levels are also decreased in Jasmine mice, demonstrating a new role for mouse TAP2 in stabilizing TAP1 protein expression.
The frequency of the TRPC4AP haplotype in Alzheimer's patients.
Huang et al., Augusta, United States. In Neurosci Lett, 2009
The latent classification method of analysis showed that the TRPC4AP H1 haplotype was characteristic of Alzheimer's patients, with ages-of-onset between 66 and 80 years.
Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis.
Smith et al., Augusta, United States. In Am J Med Genet B Neuropsychiatr Genet, 2009
results suggest that TRPC4AP is involved with the disease in these late-onset Alzheimer's families
Reduced expression of the transporter associated with antigen processing 1 molecule in malignant glioma cells, and its restoration by interferon-gamma and -beta.
Naganuma et al., Japan. In J Neurosurg, 2006
METHODS: Five glioma cells expressed undetectable or very low levels of TAP1 protein and did not express TAP1 messenger (m)RNA.
IFN regulatory factor-2 cooperates with STAT1 to regulate transporter associated with antigen processing-1 promoter activity.
Dusanter-Fourt et al., Paris, France. In J Immunol, 2005
In this study we report that IFN-gamma and thrombopoietin (TPO) strongly increase TAP1 protein expression in megakaryocytes, followed by an enhanced expression of MHC(I) on the cell surface.
TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB.
Riches et al., Denver, United States. In Mol Cell Biol, 2003
cloning and characterization of tumor necrosis factor receptor 1 (TNF-R1)-associated ubiquitous scaffolding and signaling protein (TRUSS)
Impaired transporter associated with antigen processing (TAP) function attributable to a single amino acid alteration in the peptide TAP subunit TAP1.
Seliger et al., Mainz, Germany. In J Immunol, 2003
Thus, biochemical and functional evidence is presented that the Glu(263) of the TAP1 protein, but not the Phe(265), is critical for proper TAP function.
Tobacco reduces membrane HLA class I that is restored by transfection with transporter associated with antigen processing 1 cDNA.
McCutcheon et al., New York City, United States. In J Immunol, 2002
Culture in tobacco extracts, but not extracts of other substances, reduces TAP1 protein, but does not reduce expression of HLA class I H chain, L chain, or the housekeeping protein beta-actin.
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