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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

tankyrase 2, TNKS2, TANK2, TNKL
Top mentioned proteins: tankyrase, POLYMERASE, TRF1, CAN, Axin
Papers using tankyrase 2 antibodies
The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease.
Hotchin Neil A., In PLoS ONE, 2004
... cDNAs for human RNF146 (NM_030963), TNKS1 (NM_003747), TNKS2 (NM_025235), and PARP1 (NM_001618) were purchased from OriGene and subcloned into pRK ...
Papers on tankyrase 2
Development and structural analysis of adenosine site binding tankyrase inhibitors.
Lehtiö et al., Oulu, Finland. In Bioorg Med Chem Lett, Feb 2016
The scaffold also enables a fine modulation of selectivity towards either tankyrase 1 or tankyrase 2. In order to get insight about the binding mode of the inhibitors, we solved crystal structures of the compounds in complex with tankyrase 2. The compounds bind to the adenosine pocket of the catalytic domain and cause changes in the protein structure that are modulated by the chemical modifications of the compounds.
MicroRNA-1 down-regulates proliferation and migration of breast cancer stem cells by inhibiting the Wnt/β-catenin pathway.
Liu et al., Changchun, China. In Oncotarget, Jan 2016
Enhanced miR-1 expression significantly reduced the Frizzled 7 and Tankyrase-2 (TNKS2)-regulated luciferase activity in 293T cells and decreased Frizzled 7, TNKS2, c-Myc, octamer-binding transcription factor 4 (Oct4) and Nanog expression and the ratios of nuclear to cytoplasmic β-catenin as well as β-catenin-dependent luciferase activity in breast CSCs in vitro.
Genetic variants in the TEP1 gene are associated with prostate cancer risk and recurrence.
Ye et al., Shanghai, China. In Prostate Cancer Prostatic Dis, Dec 2015
After adjustment for clinicopathologic risk factors, the presence of heterozygotes or rare homozygotes of TEP1 rs1760904 and TNKS2 rs1539042 were associated with BCR in the RP cohorts (hazard ratio: 0.53, 95% CI: 0.36-0.79,
Tankyrase 2 (TNKS2) polymorphism associated with risk in developing non-small cell lung cancer in a Chinese population.
Zhang et al., Hangzhou, China. In Pathol Res Pract, Oct 2015
OBJECTIVES: We investigated the association between poly(ADP-ribose) polymerase Tankyrase 2 (TNKS2) single-nucleotide polymorphisms (SNPs) and the risk of developing non-small cell lung cancer (NSCLC) in a Han Chinese population.
Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells.
So et al., Stanford, United States. In Oncotarget, Oct 2015
Within this pathway, the tankyrase enzymes (TNKS1 and TNKS2) degrade AXIN and thereby enhance β-catenin activity.
Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics.
Lehtiö et al., Oulu, Finland. In Bioorg Med Chem, Sep 2015
Crystal structures of tankyrase 2 with the compounds showed that they bind to the nicotinamide binding site of the catalytic domain.
Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases.
Threadgill et al., Bath, United Kingdom. In Bioorg Med Chem, Aug 2015
One compound (7-(4-bromophenyl)-1-methyl-1,2,3,4-tetrahydro-1,6-naphthyridin-5-one) showed 70-fold selectivity for inhibition of tankyrase-2 versus tankyrase-1.
Global Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans.
Rotimi et al., Bethesda, United States. In J Endocrinol Metab, Jun 2015
Telomere extension by telomerase (HNRNPA1, TNKS2), D-myo-inositol (1, 4, 5)-trisphosphate biosynthesis (PIP5K1A, PIP4K2A), and regulation of actin-based motility by Rho (ARPC3) were the most significant canonical pathways and overlay with T2D signaling pathway.
Tankyrases as drug targets.
Krauss et al., Oulu, Finland. In Febs J, 2013
Tankyrase 1 and tankyrase 2 are poly(ADP-ribosyl)ases that are distinguishable from other members of the enzyme family by the structural features of the catalytic domain, and the presence of a sterile α-motif multimerization domain and an ankyrin repeat protein-interaction domain.
miR-20a promotes migration and invasion by regulating TNKS2 in human cervical cancer cells.
Tang et al., Tianjin, China. In Febs Lett, 2012
Data suggest that miR-20a can promote migration and invasion of cervical cancer cells through the upregulation of TNKS2.
Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors.
Weigelt et al., Stockholm, Sweden. In Nat Biotechnol, 2012
Here we evaluated a series of 185 small-molecule inhibitors, including research reagents and compounds being tested clinically, for the ability to bind to the catalytic domains of 13 of the 17 human PARP family members including the tankyrases, TNKS1 and TNKS2.
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.
Sicheri et al., Toronto, Canada. In Cell, 2012
Study reports crystal structures of a representative ankyrin repeat clusters of TNKS2 bound to targeting peptides from six substrates.
Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.
Costa et al., San Francisco, United States. In Plos One, 2010
RNF146 RING-type ubiquitin E3 ligase as a positive regulator of Wnt signaling that operates with tankyrase to maintain low steady-state levels of Axin proteins
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.
Cong et al., Cambridge, United States. In Nature, 2009
Using a quantitative chemical proteomic approach, we discovered that XAV939 stabilizes axin by inhibiting the poly-ADP-ribosylating enzymes tankyrase 1 and tankyrase 2. Both tankyrase isoforms interact with a highly conserved domain of axin and stimulate its degradation through the ubiquitin-proteasome pathway.
Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients.
Nedospasov et al., Moscow, Russia. In Cancer Immunol Immunother, 2008
TNKL and TNKS are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients
Isolation and physicochemical properties of tankyrase of human embryonic kidney cells of line 293.
Kuimov et al., Moscow, Russia. In Biochemistry (mosc), 2008
pH dependence and kinetic study of the enzyme activity of tankyrase 2.
Tankyrase function at telomeres, spindle poles, and beyond.
Smith et al., New York City, United States. In Biochimie, 2008
An understanding of how tankyrase 1 functions at telomeres has been confounded by its complexity; it localizes to multiple subcellular sites, it has many diverse binding partners, and it has a closely related homolog (tankyrase 2) with which it may functionally overlap.
The emerging role of poly(ADP-ribose) polymerase-1 in longevity.
Beneke et al., Konstanz, Germany. In Int J Biochem Cell Biol, 2005
In particular, tankyrase-1, tankyrase-2, PARP-2 as well as PARP-1 have been found in association with telomeric DNA and are able to poly(ADP-ribosyl)ate the telomere-binding proteins TRF-1 and TRF-2, thus blocking their DNA-binding activity and controlling telomere extension by telomerase.
Importance of poly(ADP-ribose) polymerases in the regulation of DNA-dependent processes.
Oei et al., Berlin, Germany. In Cell Mol Life Sci, 2005
Two other nuclear PARP enzymes, tankyrase-1 and tankyrase-2, are important for telomere maintenance.
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