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Talin 2

Talin2, TLN2
This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, vinculin, CAN, V1a, miR
Papers using Talin2 antibodies
Talin depletion reveals independence of initial cell spreading from integrin activation and traction
Monkley Susan J. et al., In European Journal of Cell Biology, 2007
... Mouse talin1 cDNAs and human talin2 cDNA were amplified by PCR and cloned into either pEGFP-N1 (Clontech) or mCherry-N1 (a kind ...
Papers on Talin2
Extracellular rigidity sensing by talin isoform-specific mechanical linkages.
Grashoff et al., Martinsried, Germany. In Nat Cell Biol, Dec 2015
Intriguingly, talin mechanics are isoform specific so that expression of either talin-1 or talin-2 modulates extracellular rigidity sensing.
Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish.
Xiong et al., Beijing, China. In Faseb J, Dec 2015
tln1, but neither tln2 nor -2a, was dominantly expressed in the heart and vessels.
Proteins involved in focal adhesion signaling pathways are differentially regulated in experimental branch retinal vein occlusion.
Vorum et al., Aalborg, Denmark. In Exp Eye Res, Sep 2015
Proteins involved in focal adhesion signaling included collagen α-2 chain, laminin subunit β-2, laminin subunit γ-1, lipocalin-7, nidogen-2, osteopontin, integrin-β, α-actinin-1, isoform 2 of α-actinin-1, talin-2 and filamin C. The identified proteins indicate that BRVO was associated with extracellular matrix remodeling processes.
Genomic landscape of adenoid cystic carcinoma of the breast.
Weigelt et al., New York City, United States. In J Pathol, Jul 2015
MYB and TLN2 were affected by somatic mutations in two cases each.
Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis.
Gallick et al., Houston, United States. In Oncogene, May 2015
Using knockdown experiments, we first demonstrated that talin1, but not talin2, is important in β1 integrin activation.
Characterization of miR-126-3p and its target talin2 in the bovine corpus luteum during the oestrus cycle.
Zhang et al., Changchun, China. In Reprod Domest Anim, 2014
It was revealed that miR-126-3p could target talin2 (TLN2) directly by binding the responsive element within the 3'-UTR.
Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.
Ross et al., San Diego, United States. In J Biol Chem, 2013
Vertebrates contain two talin genes, tln1 and tln2.
Clinical utility of measuring expression levels of KAP1, TIMP1 and STC2 in peripheral blood of patients with gastric cancer.
Wang et al., Hangzhou, China. In World J Surg Oncol, 2012
METHODS: Real-time reverse transcription-polymerase chain reaction was used to detect the expression levels of KAP1, TIMP1, STC2, talin 2 (TLN2), sushi-repeat-containing protein, X-linked 2 (SRPX2) and secreted protein, acidic, cysteine-rich (SPARC) in the patients' peripheral blood karyocytes.
Regulator of G-Protein Signalling-14 (RGS14) Regulates the Activation of αMβ2 Integrin during Phagocytosis.
Caron et al., Birmingham, United Kingdom. In Plos One, 2012
Surprisingly, overexpression of talin2 or RAPL had no effect on αMβ2 regulation.
Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.
Critchley et al., Leicester, United Kingdom. In Biochem Biophys Res Commun, 2012
Mice homozygous for several Tln2 gene targeted alleles are viable and fertile.
Talin, vinculin and nestin expression in orofacial muscles of dystrophin deficient mdx mice.
Kunert-Keil et al., Greifswald, Germany. In Arch Immunol Ther Exp (warsz), 2012
To determine a potential role of cytoskeletal proteins in the regeneration process of mdx masticatory muscles, we examined the expression of talin 1, talin 2, vinculin and nestin in 100-day-old control and mdx mice using quantitative RT-PCR, Western blot analyses and histochemistry.
New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.
Monkley et al., Leicester, United Kingdom. In Eur J Cell Biol, 2012
Talin1 was concentrated in peripheral focal adhesions while talin2 was observed in both focal and fibrillar adhesions, and knock-down of talin2 compromised fibronectin fibrillogenesis
Modulation of MicroRNA-194 and cell migration by HER2-targeting trastuzumab in breast cancer.
Bast et al., Houston, United States. In Plos One, 2011
Increased miR-194 expression markedly reduced levels of the cytoskeletal protein talin2 and specifically inhibited luciferase reporter activity of a talin2 wild-type 3'-untranslated region, but not that of a mutant reporter, indicating that talin2 is a direct downstream target of miR-194.
Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle.
Gregorio et al., Tucson, United States. In Circ Res, 2011
Fxr1 knockout hearts exhibit an up-regulation of desmoplakin and talin2 proteins, which is accompanied by severe disruption of desmosome as well as costamere architecture and composition in the heart
Structural diversity in integrin/talin interactions.
Campbell et al., Oxford, United Kingdom. In Structure, 2011
Structural diversity in integrin/talin interactions.
Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas.
Helland et al., Oslo, Norway. In Bmc Cancer, 2010
Data show that SCGB3A1 was down-regulated in invasive compared with DCIS, whereas talin 2 (TLN2) and PTGS1 were up-regulated in invasive compared with DCIS.
Talin 2 concentrations in cerebrospinal fluid in patients with epilepsy.
Wang et al., Chongqing, China. In Clin Biochem, 2010
the differential concentration of CSF and serum-talin 2 in the drug-refractory postencephalitic epilepsy group is an intractability-related phenomenon that might be involved in the development of RPEE
Vinculin and talin: focus on the myocardium.
Ross et al., Los Angeles, United States. In J Investig Med, 2009
This review discusses the general function of talin 1 and talin 2, as well as vinculin/metavinulin, with emphasis on what is understood about their role in the cardiac myocyte and in whole heart.
Talin depletion reveals independence of initial cell spreading from integrin activation and traction.
Sheetz et al., New York City, United States. In Nat Cell Biol, 2008
Depletion of talin2 in talin1-null cells did not affect the initiation of matrix-activated spreading or Src family kinase activation, but abolished the extracellular matrix-integrin-cytoskeleton linkage, sustained cell spreading and adhesion.
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