Dysregulation of X-linked gene expression in Klinefelter's syndrome and association with verbal cognition.
Irvine, United States. In Am J Med Genet B Neuropsychiatr Genet, 2007
The 14 X chromosome DEGs were not differentially expressed in prior studies comparing female and male brains suggesting a dysregulation profile unique to KS. Examination of X-linked DEGs, such as GTPBP6, TAF9L, and CXORF21, that show verbal cognition-gene expression correlations may establish a causal link between these genes, neurodevelopment, and language function.