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TAF5-like RNA polymerase II, p300/CBP-associated factor

TAF5L, PAF65beta, hPAF65beta
The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, TBP, CAN, p300, TAFII
Papers on TAF5L
Complex multi-block analysis identifies new immunologic and genetic disease progression patterns associated with the residual β-cell function 1 year after diagnosis of type 1 diabetes.
Nielsen et al., Copenhagen, Denmark. In Plos One, 2012
(2) A second pattern of high ZnT8 autoantibody levels and low postprandial glucagon levels associated with risk alleles of IFIH1, TCF2, TAF5L, IL2RA and PTPN2 and protective alleles of ERBB3 gene (P = 0.0005).
High levels of γ-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer.
Einbeigi et al., Göteborg, Sweden. In Bmc Cancer, 2012
The aim of this study was to determine the correlation of γ-glutamyl hydrolase (GGH), fatty acid amide hydrolase (FAAH), Pirin (PIR) and TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65 kDa (TAF5L), selected from identified gene signatures, with clinical outcomes as well as classical clinicopathological characteristics in primary invasive breast cancer patients.
Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression.
Montminy et al., Los Angeles, United States. In Embo J, 2007
latent cytoplasmic coactivator TORC2 mediates target gene activation in response to cAMP signaling by associating with CBP/p300 and increasing its recruitment to a subset of CREB target genes
The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.
Todd et al., Cambridge, United Kingdom. In Bmc Med Genet, 2006
In addition, we tested seven genes, TAF5L, PDCD1, TCF7, IL12B, IL6, ICAM1 and TBX21, with published marginal or inconsistent evidence of an association with type 1 diabetes.
Muscle cell survival mediated by the transcriptional coactivators p300 and PCAF displays different requirements for acetyltransferase activity.
Rotwein et al., Portland, United States. In Am J Physiol Cell Physiol, 2006
p300 or PCAF maintains myoblast viability as effectively as added growth factors through mechanisms requiring the acetyltransferase activity of PCAF but not of p300.
PCAF modulates PTEN activity.
Furnari et al., San Diego, United States. In J Biol Chem, 2006
PCAF is a histone acetyltransferase which regulates gene transcription. PCAF interacts physically and functionally with PTEN. PTEN acetylation by PCAF block the ability of PTEN to downregulate PI3-K signalling and to induce G1 cell cycle arrest.
Gene expression profiles of small-cell lung cancers: molecular signatures of lung cancer.
Nakamura et al., Tokyo, Japan. In Int J Oncol, 2006
Some of them are known to be transcription factors and/or gene expression regulators such as TAF5L, TFCP2L4, PHF20, LMO4, TCF20, RFX2, and DKFZp547I048 as well as those encoding nucleotide-binding proteins such as C9orf76, EHD3, and GIMAP4.
Developmental and cell type-specific regulation of core promoter transcription factors in germ cells of frogs and mice.
DeJong et al., Richardson, United States. In Gene Expr Patterns, 2006
Four of these factors, TRF3, TAF4L, TAF5L, and the previously-characterized ALF gene, are preferentially expressed in testis and ovary.
Six lysine residues on c-Myc are direct substrates for acetylation by p300.
Martinez et al., Riverside, United States. In Biochem Biophys Res Commun, 2005
p300 can acetylate DNA-bound Myc:Max complexes and that acetylated Myc:Max heterodimers efficiently interact with Miz-1
The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients.
Nosikov et al., Leuven, Belgium. In Autoimmunity, 2005
The TAF5L gene on chromosome 1q42 is associated tie type 1 diabetes in Russian patients.
Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis.
Van Dorsselaer et al., Strasbourg, France. In Proteomics, 2003
This new characterization of TFTC complex confirmed the presence of already described subunits (TRRAP, GCN5, SAP130/KIA0017, TAF(II)150, TAF(II)135, TAF(II)100, TAF(II)80, TAF(II)20, SPT3 and PAF65beta).
Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.
Tora et al., Strasbourg, France. In J Biol Chem, 1999
Furthermore, we identified four other previously uncharacterized subunits of TFTC: hADA3, hTAFII150, hSPT3, and hPAF65beta.
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