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TAF10 RNA polymerase II, TATA box binding protein

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: TBP, TAF, POLYMERASE, Histone, CAN
Papers on TAF10
LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation.
Peir├│ et al., Barcelona, Spain. In Mol Cell, Jul 2015
Using an unbiased proteomic approach, we have identified methylated TAF10, a member of the TFIID complex, as a LOXL2 substrate.
TAF10 Interacts with the GATA1 Transcription Factor and Controls Mouse Erythropoiesis.
Tora et al., Amsterdam, Netherlands. In Mol Cell Biol, Jun 2015
The contribution of the two TAF10-containing complexes (TFIID, SAGA) to erythropoiesis remains elusive.
Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules.
Berger et al., Grenoble, France. In Nat Commun, 2014
Here we describe a heterotrimeric TFIID subcomplex consisting of the TAF2, TAF8 and TAF10 proteins, which assembles in the cytoplasm.
dTAF10- and dTAF10b-Containing Complexes Are Required for Ecdysone-Driven Larval-Pupal Morphogenesis in Drosophila melanogaster.
Pankotai et al., Szeged, Hungary. In Plos One, 2014
The simultaneous deletion of both dTaf10 genes impaired the recruitment of the dTFIID subunit dTAF5 to polytene chromosomes, while binding of other TFIID subunits, dTAF1 and RNAPII was not affected.
Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives.
Yokoyama et al., Yokohama, Japan. In Acta Crystallogr D Biol Crystallogr, 2013
SET7/9 is a protein lysine methyltransferase that methylates histone H3 and nonhistone proteins such as p53, TAF10 and oestrogen receptor ╬▒.
The architecture of human general transcription factor TFIID core complex.
Berger et al., Grenoble, France. In Nature, 2013
We further demonstrate that binding of one TAF8-TAF10 complex breaks the original symmetry of core-TFIID.
Cloning and bioinformatic analysis of full-length novel pepper (Capsicum annuum) genes TAF10 and TAF13.
Deng et al., Kunming, China. In Genet Mol Res, 2012
We isolated two TATA-binding protein-associated factor (TAF) genes, TAF10 and TAF13, from pepper (Capsicum annuum).
A novel TBP-TAF complex on RNA polymerase II-transcribed snRNA genes.
Murphy et al., Oxford, United Kingdom. In Transcription, 2012
Interestingly, the largest TAF, TAF1, and the core TAFs, TAF10 and TAF4, are not detected on snRNA genes.
The integrator complex recognizes a new double mark on the RNA polymerase II carboxyl-terminal domain.
Murphy et al., Oxford, United Kingdom. In J Biol Chem, 2010
The carboxyl-terminal domain of the largest subunit of RNA polymerase II (pol II) comprises multiple tandem repeats of a heptapeptide.
CDKN1C negatively regulates RNA polymerase II C-terminal domain phosphorylation in an E2F1-dependent manner.
Cress et al., Tampa, United States. In J Biol Chem, 2010
CDKN1C negatively regulates RNA polymerase II C-terminal domain phosphorylation in an E2F1-dependent manner
Validation of reference genes for quantitative expression analysis by real-time RT-PCR in Saccharomyces cerevisiae.
Parrou et al., Toulouse, France. In Bmc Mol Biol, 2008
Using the algorithm geNorm, ALG9, TAF10, TFC1 and UBC6 turned out to be genes whose expression remained stable, independent of the growth conditions and the strain backgrounds tested in this study.
Dominant and redundant functions of TFIID involved in the regulation of hepatic genes.
Talianidis et al., Greece. In Mol Cell, 2008
To study the in vivo role of TFIID in the transcriptional regulation of hepatic genes, we generated mice with liver-specific disruption of the TAF10 gene.
Estrogen-induced and TAFII30-mediated gene repression by direct recruitment of the estrogen receptor and co-repressors to the core promoter and its reversal by tamoxifen.
Ratnam et al., Toledo, United States. In Oncogene, 2008
TAFII30 was required for optimal P4 promoter activity and for the repressive association of estrogen receptor.
Temporary expression of the TAF10 gene and its requirement for normal development of Arabidopsis thaliana.
Izui et al., Kyoto, Japan. In Plant Cell Physiol, 2007
TAF10 is a selective TATA-box binding protein-associated factor in plants, involved in pleiotropic, but selected morphological events in Arabidopsis. [TAF10]
Identification of a small TAF complex and its role in the assembly of TAF-containing complexes.
Tora et al., Strasbourg, France. In Plos One, 2006
The latter has to be involved in a pathway of complex formation distinct from the other known TAF complexes, since these three histone fold (HF)-containing proteins (TAF8, TAF10 and SPT7L) can never be found together either in TFIID or in STAGA/TFTC HAT complexes.
Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation.
Niedenthal et al., Hannover, Germany. In Nucleic Acids Res, 2006
Of these, three were constitutively SUMOylated (FOS, CRSP9 and CDC37) while the remaining five substrates (CSNK2B, TAF10, HSF2BP, PSMC3 and DRG1) showed a stimulation-dependent SUMOylation induced by the MAP3 kinase MEKK1.
The Arabidopsis mutant stg1 identifies a function for TBP-associated factor 10 in plant osmotic stress adaptation.
Lu et al., Wuhan, China. In Plant Cell Physiol, 2006
Overexpression of TAF10 in Arabidopsis improves seed tolerance to salt stress during germination and the knocked-down mutant is more sensitive to salt stress.[TAF10]
Regulation of spermatogenesis by testis-specific, cytoplasmic poly(A) polymerase TPAP.
Baba et al., Tsukuba, Japan. In Science, 2003
Although the overall cellular level of the transcription factor TAF10 is unaffected, TAF10 is insufficiently transported into the nucleus of germ cells.
Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor.
Tora et al., Strasbourg, France. In Cell, 1994
We have characterized a human TBP-associated factor (TAF), hTAFII30, associated with a subset of TFIID complexes.
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