Cell-cycle arrest and acute kidney injury: the light and the dark sides.
Pittsburgh, United States. In Nephrol Dial Transplant, Jan 2016
We recently reported results from multi-center studies where two urinary markers of cell-cycle arrest, tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) were validated for development of AKI well ahead of clinical manifestations-azotemia and oliguria.
OMA-gosh, where's that TAF?
Boston, United States. In Cell, 2008
In this issue, Guven-Ozkan et al. (2008) report that transcriptional repression during worm embryogenesis is mediated through sequestration of the general transcription factor TAF-4 and is regulated by mechanisms that orchestrate the transition between maternal and zygotic gene expression.