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Transforming, acidic coiled-coil containing protein 3

This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: Aurora, Msps, FGFR3, CAN, POLYMERASE
Papers using TACC3 antibodies
A B-Myb complex containing clathrin and filamin is required for mitotic spindle function
Shih Hsiu-Ming et al., In The Journal of Cell Biology, 2007
... following primary antibodies were used: rabbit anti-TACC3 (H-300), mouse anti-TACC3 (D-2), control mouse IgG, and rabbit IgG (Santa Cruz Biotechnology, ...
Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis
Hyman Anthony A. et al., In The Journal of Cell Biology, 1987
... Full-length TACC3 cDNA was subcloned into pET30 vector (CLONTECH Laboratories, Inc.) for expression ...
Papers on TACC3
The clinical significance of transforming acidic coiled-coil protein 3 expression in non-small cell lung cancer.
Zhang et al., Taiwan. In Oncol Rep, Jan 2016
The relationship between TACC3, a member of the transforming acidic coiled-coil proteins (TACCs) family, and lung carcinoma remains unclear.
Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms.
Silverman et al., Bethesda, United States. In J Natl Cancer Inst, Nov 2015
and rs798766 (TMEM129-TACC3-FGFR3, P interaction = .03).
TACC3 promotes stemness and is a potential therapeutic target in hepatocellular carcinoma.
Zeng et al., Guangzhou, China. In Oncotarget, Oct 2015
Transforming acidic coiled-coil protein 3 (TACC3) is essential for cell mitosis and transcriptional functions.
FGFR3-TACC3: A novel gene fusion in cervical cancer.
Johnson et al., Cambridge, United States. In Gynecol Oncol Rep, Aug 2015
We report the first three cases of cervical carcinoma harboring an FGFR3-TACC3 fusion, which serves as a novel therapeutic target.
Transforming acidic coiled-coil-containing protein 3 (TACC3) overexpression in hepatocellular carcinomas is associated with "stemness" and epithelial-mesenchymal transition-related marker expression and a poor prognosis.
Park et al., Seoul, South Korea. In Tumour Biol, Aug 2015
We performed an immunohistochemical analysis of transforming acidic coiled-coil-containing protein 3 (TACC3) expression in HCCs in whole tissue sections and tissue microarrays and examined the clinicopathological characteristics of TACC3-overexpressing HCCs in relation to stemness-related marker (K19, EpCAM) expression, epithelial-mesenchymal transition (EMT)-related proteins, and survival.
Comprehensive molecular characterization of urothelial bladder carcinoma.
Cancer Genome Atlas Research Network, In Nature, 2014
Whole-genome and RNA sequencing identified recurrent in-frame activating FGFR3-TACC3 fusions and expression or integration of several viruses (including HPV16) that are associated with gene inactivation.
FGF receptors: cancer biology and therapeutics.
Nakagama et al., Tokyo, Japan. In Med Res Rev, 2014
FGFR1 and FGFR3 genes are fused to neighboring TACC1 and TACC3 genes, respectively, due to interstitial deletions in glioblastoma multiforme.
Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients.
Park et al., Seoul, South Korea. In J Clin Oncol, 2014
We also uncovered recurrent occurrence of therapeutically actionable FGFR3-TACC3 fusion in lung SCC.
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation.
Cai et al., Shenzhen, China. In Nat Genet, 2013
Furthermore, we also detected a recurrent fusion involving FGFR3 and TACC3, another component of SCCS, by transcriptome sequencing of 42 DNA-sequenced tumors.
Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division.
Piekorz et al., In Biol Chem, 2013
Here, we focus on members of the transforming acidic coiled coil (TACC) family of centrosomal adaptor proteins, in particular TACC3, in which their subcellular localization at the mitotic spindle apparatus is controlled by Aurora-A kinase-mediated phosphorylation.
Transforming fusions of FGFR and TACC genes in human glioblastoma.
Iavarone et al., New York City, United States. In Science, 2012
study reports that a small subset of glioblastoma multiforme tumors harbors oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase coding domains of fibroblast growth factor receptor genes(FGFR1 or FGFR3) to the transforming acidic coiled-coil coding domains of TACC1 or TACC3; the FGFR-TACC fusion protein displays oncogenic activity
DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.
Van Aelst et al., New York City, United States. In Nat Neurosci, 2012
DOCK7 interaction with TACC3 controls interkinetic nuclear migration and the genesis of neurons from radial glial progenitor cells during cortical development
Disruption of Tacc3 function leads to in vivo tumor regression.
Noda et al., Tokyo, Japan. In Oncogene, 2012
results show that Tacc3 is a vulnerable component of the spindle assembly in lymphoma cells and is a promising cancer chemotherapy target
The role of clathrin in mitotic spindle organisation.
Royle, Liverpool, United Kingdom. In J Cell Sci, 2012
This mitotic function is unrelated to the role of clathrin in membrane trafficking and occurs in partnership with two other spindle proteins: transforming acidic coiled-coil protein 3 (TACC3) and colonic hepatic tumour overexpressed gene (ch-TOG; also known as cytoskeleton-associated protein 5, CKAP5).
High-efficiency counterselection recombineering for site-directed mutagenesis in bacterial artificial chromosomes.
Stewart et al., Dresden, Germany. In Nat Methods, 2012
Using this approach, we generated mutated TACC3 transgenes to identify phosphorylation-specific spindle defects after knockdown of endogenous TACC3 expression.
Novel functions of endocytic player clathrin in mitosis.
Zhang et al., Beijing, China. In Cell Res, 2011
In mitosis, clathrin forms a complex with phosphorylated TACC3 to ensure spindle stability and proper chromosome alignment.
A novel 4p16.3 microduplication distal to WHSC1 and WHSC2 characterized by oligonucleotide array with new phenotypic features.
Shchelochkov et al., Iowa City, United States. In Am J Med Genet A, 2011
we have identified a novel submicroscopic duplication involving dosage sensitive genes TACC3, FGFR3, and LETM1.
Genetic variants in urinary bladder cancer: collective power of the "wimp SNPs".
Hengstler et al., Dortmund, Germany. In Arch Toxicol, 2011
These SNPs are located next to the following genes: MYC, TP63, PSCA, the TERT-CLPTM1L locus, FGFR3, TACC3, NAT2, CBX6, APOBEC3A, CCNE1, and UGT1A.
A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging.
Royle et al., Liverpool, United Kingdom. In Embo J, 2011
TACC3 recruits ch-TOG and clathrin to the mitotic spindle. Together the complex forms inter-microtubule bridges in kinetochore fibres.
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