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Transforming, acidic coiled-coil containing protein 2

TACC2, AZU-1, anti-zuai-1, ECTACC
Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TACC1, CAN, TACC3, CAP37, FGFR2
Papers on TACC2
Whole exome sequencing identifies novel candidate genes that modify chronic obstructive pulmonary disease susceptibility.
Nyunoya et al., Albuquerque, United States. In Hum Genomics, Dec 2015
CONCLUSIONS: Our integrative analysis through both genetic and functional approaches identified two candidate genes (TACC2 and MYO1E) that augment cigarette smoke (CS)-induced cytotoxicity and, potentially, COPD susceptibility.
GWA meta-analysis of personality in Korean cohorts.
Kim et al., Seoul, South Korea. In J Hum Genet, Aug 2015
We investigated the top five single-nucleotide polymorphisms (SNPs) for each trait, and revealed the most highly association with neuroticism and TACC2 (rs1010657, P=8.79 × 10(-7)), extraversion and PTPN12 (rs12537271, P=1.47 × 10(-7)), openness and IMPAD1 (rs16921695, P=5 × 10(-8)), agreeableness and RPS29 (rs8015351, P=1.27 × 10(-6)) and conscientiousness and LMO4 (rs912765, P=2.91 × 10(-6)).
Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.
Zhong et al., Xinpu, China. In Bmc Pregnancy Childbirth, 2014
Differential expression of the transcripts PPP2R5C, STAM, TACC2, EML4, PAM, PDE4B, STAM, PPP2R5C, PDE4B, and EGFR indicated a co-expression among these mRNAs, which are involved in the ubiquitine-proteasome system (UPS), in addition to signaling transduction and beta adrenergic signaling, suggesting that imbalanced regulation of UPS may present an additional mechanism underlying the premature rupture of membrane in PPROM.
Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade.
Couch et al., Detroit, United States. In Hum Mol Genet, 2014
SNPs in TACC2 [rs17550038: odds ratio (OR) = 1.24, 95% confidence interval (CI) 1.16-1.33,
Cardiomyocyte cytokinesis score: a potential method for cardiomyocyte proliferation.
Hu et al., Beijing, China. In Cell Biol Int, 2014
Given the disturbances of nuclear division without cell division that occurs in cardiomyocytes, ten cytokinesis-correlated genes (Anln, Aurkb, Cenpa, Kif4, Kif23, Prc1, RhoA, Spin1, TACC2, and CDC42) were chosen to establish the cardiomyocyte cytokinesis score (CC-Score).
DNA methylation status is more reliable than gene expression at detecting cancer in prostate biopsy.
Ostrowski et al., Warsaw, Poland. In Br J Cancer, 2014
By contrast, DNA methylation levels of the APC, TACC2, RARB, DGKZ and HES5 promoter regions achieved high discriminating sensitivity and specificity, with area under the curve (AUCs) reaching 0.95-1.0.
Glucocorticoid-induced reversal of interleukin-1β-stimulated inflammatory gene expression in human oviductal cells.
Brown et al., Toronto, Canada. In Plos One, 2013
Quantitative real time RT-PCR studies validated the gene array data for IL8, IL23A, PI3 and TACC2 in OE-E6/E7 cells.
RBFOX1 cooperates with MBNL1 to control splicing in muscle, including events altered in myotonic dystrophy type 1.
Chabot et al., Sherbrooke, Canada. In Plos One, 2013
SORBS1, TACC2, TTN, ACTN1 and DMD) and channel (e.g.
TACC2 is an androgen-responsive cell cycle regulator promoting androgen-mediated and castration-resistant growth of prostate cancer.
Inoue et al., Tokyo, Japan. In Mol Endocrinol, 2012
Data suggest that TACC2 is highly expressed in prostate cancer cells and contributes to cell cycle progression and cell proliferation in androgen-nonresponsive prostate cancer cells; overexpression of TACC2 leads to recurrence of prostate cancer.
Genetic polymorphisms in oestrogen receptor-binding sites affect clinical outcomes in patients with prostate cancer receiving androgen-deprivation therapy.
Bao et al., Kao-hsiung, Taiwan. In J Intern Med, 2012
RESULTS: Based on multiple hypothesis testing, BNC2 rs16934641 was found to be associated with disease progression; in addition, TACC2 rs3763763 was associated with PCSM, and ALPK1 rs2051778 and TACC2 rs3763763 were associated with ACM.
Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study.
Willman et al., Albuquerque, United States. In Blood, 2012
Results revealed 3 genes highly predictive of event-free survival (EFS), beyond age and MLL status: FLT3, IRX2, and TACC2.
Transforming acidic coiled-coil-containing protein 2 (TACC2) in human breast cancer, expression pattern and clinical/prognostic relevance.
Jiang et al., Cardiff, United Kingdom. In Cancer Genomics Proteomics, 2010
TACC2 may mediate an oncogenic effect on breast cancer cells.
Simian virus 40 large T antigen targets the microtubule-stabilizing protein TACC2.
Nakao et al., Kumamoto, Japan. In J Cell Sci, 2009
Simian virus 40 large T antigen interacting with TACC2 is involved in stabilizing microtubules in mitosis.
Exploiting gene expression profiling to identify novel minimal residual disease markers of neuroblastoma.
Cheung et al., New York City, United States. In Clin Cancer Res, 2008
RESULTS: Based on sensitivity assays, 8 top-ranking markers were identified: CCND1, CRMP1, DDC, GABRB3, ISL1, KIF1A, PHOX2B, and TACC2.
TTK kinase is essential for the centrosomal localization of TACC2.
Yao et al., Hefei, China. In Febs Lett, 2004
Centrosomal TACC2 is required for mitotic spindle maintenance.
AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains.
Maxwell et al., Belfast, United Kingdom. In Leuk Lymphoma, 2002
TACC2, located at 10q26, is similar to anti-zuai-1 (AZU-1), a candidate breast tumour suppressor gene, and ECTACC, an endothelial cell TACC which is upregulated by erythropoietin (Epo).
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