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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Plastin 3

T-plastin, PLS3, plastin 3
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] (from NCBI)
Top mentioned proteins: Actin, HAD, CAN, AGE, SmaI
Papers using T-plastin antibodies
Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta
Urbani Andrea et al., In Journal of Proteomics, 2005
... anti PGAM1 (6) mAb, anti-PGK1 (Y-12) Ab, anti PKM2 (H-59) Ab, anti-Stat1 (M-22) Ab and anti-T-Plastin (A-3) mAb were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Papers on T-plastin
Plastins regulate ectoplasmic specialization via its actin bundling activity on microfilaments in the rat testis.
Cheng et al., New York City, United States. In Asian J Androl, Dec 2015
A recent report using RNAi that specifically knocks down plastin 3 has yielded some insightful information regarding the mechanism by which plastin 3 regulates the status of actin microfilament bundles at the ES via its intrinsic actin filament bundling activity.
Plastin 3 is upregulated in iPSC-derived motoneurons from asymptomatic SMN1-deleted individuals.
Wirth et al., Köln, Germany. In Cell Mol Life Sci, Dec 2015
High plastin 3 (PLS3) expression has previously been found in lymphoblastoid cells but not in fibroblasts of asymptomatic compared to symptomatic siblings.
Dysregulation of the TOX-RUNX3 pathway in cutaneous T-cell lymphoma.
Geskin et al., Pittsburgh, United States. In Oncotarget, Dec 2015
qRT-PCR confirmed TOX upregulation (>7 fold increase) in SS (n = 5), as well as two established markers, PLS3 and KIRD3DL2.
Actin-bundling protein plastin 3 is a regulator of ectoplasmic specialization dynamics during spermatogenesis in the rat testis.
Cheng et al., New York City, United States. In Faseb J, Sep 2015
Plastin 3 is one of the plastin family members abundantly found in yeast, plant and animal cells that confers actin microfilaments their bundled configuration.
Sézary syndrome without erythroderma.
Maubec et al., Paris, France. In J Am Acad Dermatol, Jun 2015
Peripheral blood lymphocytes from 3 of 4 patients tested strongly expressed PLS3, Twist-1, and KIR3DL2.
Expression of the PLS3 Gene in Circulating Cells in Patients with Colorectal Cancer.
Dziki et al., In Pol Przegl Chir, Feb 2015
Plastin-3 (PL S3) is one of such markers of CTC.
Comparative proteomic analysis of hypertrophic chondrocytes in osteoarthritis.
Economou et al., Irákleion, Greece. In Clin Proteomics, 2014
We also observed that the proteins GSTP1, PLS3, MYOF, HSD17B12, PRDX2, APCS, PLA2G2A SERPINH1/HSP47 and MVP, show distinct synthesis levels, characteristic for OA or control chondrocytes.
Mutational analysis of circulating tumor cells from colorectal cancer patients and correlation with primary tumor tissue.
Gazouli et al., Athens, Greece. In Plos One, 2014
In the present study we investigated the feasibility to detect KRAS, BRAF, CD133 and Plastin3 (PLS3) mutations in an enriched CTCs cell suspension from patients with colorectal cancer, with the hypothesis that these genes` mutations are of great importance regarding the generation of CTCs subpopulations.
New Genetic Forms of Childhood-Onset Primary Osteoporosis.
Mäkitie et al., Stockholm, Sweden. In Horm Res Paediatr, 2014
This Mini Review discusses monogenetic forms of childhood-onset primary osteoporosis, with the main focus on osteoporosis caused by mutations in WNT1 and PLS3, two of the most recently discovered genes underlying early-onset osteoporosis.
Plastin 3 Expression Does Not Modify Spinal Muscular Atrophy Severity in the ∆7 SMA Mouse.
Burghes et al., Columbus, United States. In Plos One, 2014
It has been suggested that Plastin3 (PLS3) acts as a sex specific phenotypic modifier where increased expression of PLS3 modifies the SMA phenotype in females.
Decay in survival motor neuron and plastin 3 levels during differentiation of iPSC-derived human motor neurons.
Yáñez-Muñoz et al., London, United Kingdom. In Sci Rep, 2014
PLS3 underwent parallel reductions at both the transcriptional and translational levels.
What is new in genetics and osteogenesis imperfecta classification?
Zabel et al., Belo Horizonte, Brazil. In J Pediatr (rio J), 2014
Mutations in PLS3 were recently identified in families with osteoporosis and fractures, with X-linked inheritance pattern.
Lessons learned from gene expression profiling of cutaneous T-cell lymphoma.
Geskin et al., Pittsburgh, United States. In Br J Dermatol, 2013
Despite discordant results, several dysregulated genes have been identified across multiple studies, including PLS3, KIR3DL2, TWIST1 and STAT4.
PLS3 mutations in X-linked osteoporosis with fractures.
Pals et al., Amsterdam, Netherlands. In N Engl J Med, 2013
Plastin 3 (PLS3), a protein involved in the formation of filamentous actin (F-actin) bundles, appears to be important in human bone health, on the basis of pathogenic variants in PLS3 in five families with X-linked osteoporosis and osteoporotic fractures that we report here.
Regulation of T-plastin expression by promoter hypomethylation in primary cutaneous T-cell lymphoma.
Mitchell et al., London, United Kingdom. In J Invest Dermatol, 2012
PLS3 is expressed in the majority of SS patients and provide insight into the molecular regulation of PLS3 expression in CTCL
Inducible expression and pathophysiologic functions of T-plastin in cutaneous T-cell lymphoma.
Michel et al., Paris, France. In Blood, 2012
T-plastin is a marker restricted to malignant lymphocytes from Sezary syndrome patients and plays a role for cell survival and migration.
Association of plastin 3 expression with disease severity in spinal muscular atrophy only in postpubertal females.
Chung et al., New York City, United States. In Arch Neurol, 2010
The PLS3 gene may be an age- and/or puberty-specific and sex-specific modifier of spinal muscular atrophy.
Expression of T-plastin, FoxP3 and other tumor-associated markers by leukemic T-cells of cutaneous T-cell lymphoma.
Hess et al., Roma, Italy. In Leuk Lymphoma, 2008
Increased T-plastin is associated with leukemic cutaneous T-cell lymphoma
Plastin 3 is a protective modifier of autosomal recessive spinal muscular atrophy.
Wirth et al., Köln, Germany. In Science, 2008
unaffected SMN1-deleted females exhibit significantly higher expression of PLS3 than their spinal muscular atrophy-affected counterparts
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