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Transcription factor 7

T-cell factor, TCF-1
The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: TCF, TCF4, V1a, CAN, PCNA
Papers on T-cell factor
MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1.
Wei et al., Shenyang, China. In Oncol Rep, Jan 2016
The overexpression of miR-148a reduced the mRNA and protein expression levels of WNT-1, also decreased the expression levels of the key components of Wnt/β-catenin pathway, including β-catenin, metalloproteinase-7 (MMP-7) and T-cell factor-4 (TCF-4) in MCF-7 and MDA-MB-231 cells.
Therapeutic targeting of casein kinase 1δ in breast cancer.
Duckett et al., Jupiter, United States. In Sci Transl Med, Jan 2016
We also show that Wnt/β-catenin signaling is a hallmark of human tumors overexpressing CK1δ, that disabling CK1δ blocks nuclear accumulation of β-catenin and T cell factor transcriptional activity, and that constitutively active β-catenin overrides the effects of inhibition or silencing of CK1δ.
Up-regulation of SRPK1 in non-small cell lung cancer promotes the growth and migration of cancer cells.
Chen et al., Shanghai, China. In Tumour Biol, Jan 2016
Mechanism studies showed that SRPK1 activated the transcriptional activity of beta-catenin/T-cell factor (TCF) complex, and knocking down the expression of SRPK1 attenuated the expression of target genes of beta-catenin/T-cell factor (TCF) complex.
Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer.
Yamada et al., Tokyo, Japan. In Pharmacol Ther, Dec 2015
Traf2- and Nck-interacting protein kinase (TNIK) has been identified as a regulatory component of the T-cell factor-4 and β-catenin transcriptional complex independently by two research groups.
Regulation of MYC gene expression by aberrant Wnt/β-catenin signaling in colorectal cancer.
Yochum et al., United States. In World J Biol Chem, Dec 2015
T-cell factor/Lymphoid enhancer factor transcription factors bind WREs and recruit the β-catenin transcriptional co-activator to activate target gene expression.
TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow.
Bhandoola et al., Bethesda, United States. In Nat Immunol, Oct 2015
We show that the transcription factor TCF-1 is required for the efficient generation of all known adult ILC subsets and their precursors.
The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection.
Wu et al., Chongqing, China. In Nat Immunol, Sep 2015
Here we found that the transcription factor TCF-1 was essential for both the initiation of T(FH) differentiation and the effector function of differentiated T(FH) cells during acute viral infection.
LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.
Crotty et al., Los Angeles, United States. In Nat Immunol, Sep 2015
Here we report that selective loss of Lef1 or Tcf7 (which encode the transcription factor LEF-1 or TCF-1, respectively) resulted in T(FH) cell defects, while deletion of both Lef1 and Tcf7 severely impaired the differentiation of T(FH) cells and the formation of GCs.
[T Cell Factor 4, beta-catenin and SFRP1 Expression of Wnt Signaling Pathway in Colorectal Carcinoma and the Prognosis].
Dong et al., In Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, Aug 2015
Abnormal activation of Wnt signaling pathway is closely related to the occurrence of tumor, and T cell factor 4 (Tcf4 ) and beta-catenin are important signal transmission factors of this pathway.
Polyphenol Compound as a Transcription Factor Inhibitor.
Park, Seoul, South Korea. In Nutrients, 2014
In this review, we focus on polyphenol compound inhibitors against dimeric forms of transcription factor components of intracellular signaling pathways (for instance, c-jun/c-fos (Activator Protein-1; AP-1), c-myc/max, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and β-catenin/T cell factor (Tcf)).
Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells.
Zhu et al., Bethesda, United States. In Mediators Inflamm, 2014
Regulators such as Id2, GATA-3, Nfil3, TOX, and TCF-1 are expressed and function at various stages of ILC development.
Phytochemicals as Innovative Therapeutic Tools against Cancer Stem Cells.
Ninfali et al., Urbino, Italy. In Int J Mol Sci, 2014
Most of these phytochemicals act by interfering with the canonical Wnt (β-catenin/T cell factor-lymphoid enhancer factor (TCF-LEF)) pathway implicated in the pathogenesis of several cancers.
Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation.
Gandhi et al., Boston, United States. In J Neuroinflammation, 2014
Chromatin immunoprecipitation was performed to assess T cell factor 1 (TCF-1) binding to promoter regions.
TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells.
Xue et al., Iowa City, United States. In Nat Immunol, 2014
The transcription factors TCF-1 and LEF-1 are essential for early T cell development, but their roles beyond the CD4(+)CD8(+) double-positive (DP) stage are unknown.
The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.
Powell et al., Baltimore, United States. In Nat Immunol, 2014
Simultaneously, SGK1 repressed the production of interferon-γ (IFN-γ) by controlling expression of the long isoform of the transcription factor TCF-1.
A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs.
Waterman et al., Irvine, United States. In Mol Cell Biol, 2012
findings show that induction of a dominant negative C-clamp version of TCF1 (dnTCF1E) induces p21 expression and a stall in the growth of DLD1 colon cancer cells; results indicate that a rapid-response WNT/p21 circuit is driven by C-clamp target gene selection
Tcf-1 gene silence suppresses downstream gene expression in CD4(+) T cells from bone marrow of aplastic anemia patients.
Liu et al., Wuhan, China. In Ann Hematol, 2012
Results suggest that Tcf-1 may contribute to pathogenesis of acquired aplastic anemia by regulating downstream gene expression such as c-myc and CD44.
T cell factor-1 negatively regulates expression of IL-17 family of cytokines and protects mice from experimental autoimmune encephalomyelitis.
Sen et al., Baltimore, United States. In J Immunol, 2011
Transgenic T cell factor 1 (TCF1) binds to regulatory regions of the IL17 gene and directly regulates IL17A and IL17F gene expression.
Regulation of β-catenin by t-DARPP in upper gastrointestinal cancer cells.
El-Rifai et al., Nashville, United States. In Mol Cancer, 2010
Findings demonstrate that t-DARPP regulates beta-catenin/TCF activity, thereby implicating a novel oncogenic signaling in upper gastrointestinal cancers.
Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentials.
Byers et al., Lexington, United States. In Crit Rev Eukaryot Gene Expr, 2010
In this review we present mounting evidence for the interdependency of TCF7/LEF1 variant expression and functions with cell lineage and cell state. [Review]
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