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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Syntaxin 18

syntaxin 18, Stx18
member of SYP8 Gene Family (from NCBI)
Top mentioned proteins: Sec22b, NSF, p31, ZW10, 110-kDa
Papers on syntaxin 18
Recurrent acute liver failure due to NBAS deficiency: phenotypic spectrum, disease mechanisms, and therapeutic concepts.
Hoffmann et al., Heidelberg, Germany. In J Inherit Metab Dis, Jan 2016
Thermal susceptibility of the syntaxin 18 complex is the basis of fever dependency of ALF episodes.
The BH3-only SNARE BNip1 mediates photoreceptor apoptosis in response to vesicular fusion defects.
Masai et al., Okinawa, Japan. In Dev Cell, 2013
BNip1 functions as a component of the syntaxin-18 SNARE complex and regulates retrograde transport from the Golgi to the endoplasmic reticulum.
Silencing of Nicotiana benthamiana Neuroblastoma-Amplified Gene causes ER stress and cell death.
Pai et al., Seoul, South Korea. In Bmc Plant Biol, 2012
Later it was found that NAG is localized in endoplasmic reticulum (ER) and is a component of the syntaxin 18 complex that is involved in Golgi-to-ER retrograde transport in human cells.
Disruption of the fusion of Leishmania parasitophorous vacuoles with ER vesicles results in the control of the infection.
Kima et al., Gainesville, United States. In Cell Microbiol, 2012
In the presence of dominant negative variants of sec22b or some of its known cognate partners, D12 and syntaxin 18, PVs failed to distend and harboured fewer parasites.
A targeted siRNA screen to identify SNAREs required for constitutive secretion in mammalian cells.
Peden et al., Cambridge, United Kingdom. In Traffic, 2010
We have identified the endoplasmic reticulum (ER)/Golgi SNAREs syntaxin 5, syntaxin 17, syntaxin 18, GS27, SLT1, Sec20, Sec22b, Ykt6 and the SM protein Sly1, along with the post-Golgi SNAREs SNAP-29 and syntaxin 19, as being required for constitutive secretion.
Dsl1p/Zw10: common mechanisms behind tethering vesicles and microtubules.
Schmitt, Göttingen, Germany. In Trends Cell Biol, 2010
Fusion of Golgi-derived COP (coat protein)-I vesicles with the endoplasmic reticulum (ER) is initiated by specific tethering complexes: the Dsl1 (depends on SLY1-20) complex in yeast and the syntaxin 18 complex in mammalian cells.
Sec22b is a negative regulator of phagocytosis in macrophages.
Wada et al., Fukushima, Japan. In Mol Biol Cell, 2009
In support of this, we have previously shown that the expression level of syntaxin 18, an ER-localized SNARE protein, correlates with phagocytosis activity.
Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport.
Tagaya et al., Hachiōji, Japan. In Mol Biol Cell, 2009
Syntaxin 18, a soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor (SNARE) protein implicated in endoplasmic reticulum (ER) membrane fusion, forms a complex with other SNAREs (BNIP1, p31, and Sec22b) and several peripheral membrane components (Sly1, ZW10, and RINT-1).
Role of syntaxin 18 in the organization of endoplasmic reticulum subdomains.
Tani et al., Hachiōji, Japan. In J Cell Sci, 2009
Suggest that syntaxin 18 has an important role in ER subdomain organization by mediating the fusion of retrograde membrane carriers with the ER membrane.
p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival.
Harada et al., Maebashi, Japan. In Mol Cell Biol, 2009
p31, the mammalian orthologue of yeast Use1p, is an endoplasmic reticulum (ER)-localized soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) that forms a complex with other SNAREs, particularly syntaxin 18.
Effective stimulation of growth in MCF-7 human breast cancer cells by inhibition of syntaxin18 by external guide sequence and ribonuclease P.
Lee et al., Prince George, Canada. In Cancer Lett, 2009
Stx18 in involved in growth of human breast cancer cells and may possibly be used as a prognostic marker and a molecular target in the treatment of breast cancer.
Members of a mammalian SNARE complex interact in the endoplasmic reticulum in vivo and are found in COPI vesicles.
Söling et al., Göttingen, Germany. In Eur J Cell Biol, 2008
Here, we report that the mammalian soluble N-ethylmaleimide-sensitive factor (NSF) attachment receptor (SNARE) proteins mSec22b, mUse1/D12, mSec20/BNIP1, and syntaxin 18 form a quaternary SNARE complex.
Sec22b-dependent assembly of endoplasmic reticulum Q-SNARE proteins.
Tagaya et al., Hachiōji, Japan. In Biochem J, 2008
We have previously shown that ER (endoplasmic reticulum)-localized syntaxin 18 (Qa) forms a complex with BNIP1 (Qb), p31/Use1 (Qc), Sec22b (R) and several peripheral membrane proteins.
Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis.
Storrie et al., Little Rock, United States. In Mol Biol Cell, 2007
Small interfering RNA (siRNA) against RINT-1, a protein linker between ZW10 and the ER soluble N-ethylmaleimide-sensitive factor attachment protein receptor, syntaxin 18, produced similar Golgi disruption.
Bovine papillomavirus type 1 infection is mediated by SNARE syntaxin 18.
Meneses et al., North Chicago, United States. In J Virol, 2007
We identified the interaction of the L2 protein with SNARE protein syntaxin 18, which mediates the trafficking of vesicles and their cargo between the endoplasmic reticulum, the cis-Golgi compartment, and possibly the plasma membrane.
RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex.
Tagaya et al., Hachiōji, Japan. In Mol Biol Cell, 2006
RINT-1 coordinates the localization and function of ZW10 by serving as a link between ZW10 and the SNARE complex comprising syntaxin 18.
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