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Syntaxin 12

syntaxin 13, syntaxin 12, Stx12
member of the syntaxin family; binds alpha SNAP and syndet/SNAP-23 in vitro; may play a role in vesicle-mediated transport [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: V1a, Rab11, Transferrin, SNAP-25, Rab5
Papers using syntaxin 13 antibodies
Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin.
Ehlers Michael D., In PLoS Biology, 2006
... rabbit anti-myc (Upstate Biotechnology), mouse LAMP-1 (Stressgen), mouse anti-myc, rabbit anti-Rab5 (Santa Cruz Biotechnology), rabbit anti-syntaxin 13 (Synaptic Systems), human anti-EEA1, and mouse ...
Papers on syntaxin 13
STX13 regulates cargo delivery from recycling endosomes during melanosome biogenesis.
Setty et al., Bengaluru, India. In J Cell Sci, Oct 2015
We found that depletion of syntaxin 13 (STX13, also known as STX12), a recycling endosomal Qa-SNARE, inhibits pigment granule maturation in melanocytes by rerouting the melanosomal proteins such as TYR and TYRP1 to lysosomes.
Endosomal localization of FIP3/Arfophilin-1 and its involvement in dendritic formation of mouse hippocampal neurons.
Sakagami et al., Sagamihara, Japan. In Brain Res, 2014
Immunohistochemical analysis showed the association of FIP3 with a subpopulation of endosomes labeled with EEA1 and syntaxin 12 in hippocampal neurons.
Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation.
Gao et al., Worcester, United States. In Mol Cell, 2013
Knockdown of syntaxin 13 (STX13) or its binding partner Vti1a in mammalian cells caused LC3-positive puncta to accumulate and blocks autophagic flux.
Role of Rabex-5 in the sorting of ubiquitinated cargo at an early stage in the endocytic pathway.
Lee et al., Kyoto, Japan. In Commun Integr Biol, 2013
Here, we show that Rabex-5 predominantly localizes on Rab5- and syntaxin 13-positive endosomes, but not on Rab11-positive recycling endosomes before stimulation with extracellular ligands.
Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients.
Gebicke-Haerter et al., Göttingen, Germany. In Eur Arch Psychiatry Clin Neurosci, 2012
Their gene products belonged to vesicle-associated proteins, that is, synaptotagmin 6 and syntaxin 12, to cytoskeletal proteins, like myosin 6, pleckstrin, or to proteins of the extracellular matrix, such as collagens, or laminin C3.
GRASP-1 regulates endocytic receptor recycling and synaptic plasticity.
van der Sluijs et al., Rotterdam, Netherlands. In Commun Integr Biol, 2010
GRASP-1 connects Rab4 and Rab11 recycling endosomal domains through the interaction with target (t)-SNARE syntaxin 13, which constitutes a new principle for regulating endosomal recycling.
The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.
Dell'Angelica et al., Los Angeles, United States. In Mol Psychiatry, 2010
Selective biochemical interaction between brain BLOC-1 and a few members of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) superfamily of proteins that control membrane fusion, including SNAP-25 and syntaxin 13, was demonstrated.
Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes.
van der Sluijs et al., Rotterdam, Netherlands. In Plos Biol, 2010
At the molecular level, GRASP-1 segregates Rab4 from EEA1/Neep21/Rab5-positive early endosomal membranes and coordinates the coupling to Rab11-labelled recycling endosomes by interacting with the endosomal SNARE syntaxin 13.
Endosomal fusion upon SNARE knockdown is maintained by residual SNARE activity and enhanced docking.
Rizzoli et al., Göttingen, Germany. In Traffic, 2009
Surprisingly, knockdown of syntaxin 13, syntaxin 6 and vti1a, alone or in combinations, did not result in measurable changes of endosomal trafficking or fusion.
Studies on Syntaxin 12 and alcohol preference involving C57BL/6J and DBA/2J strains of mice.
Singh et al., London, Canada. In Behav Genet, 2009
Syntaxin 12 has a role as a potential contributor to alcohol preference in mice
SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery.
L'hernault et al., Atlanta, United States. In Mol Biol Cell, 2009
SPE-39 knockdown in cultured human cells altered the morphology of syntaxin 7-, syntaxin 8-, and syntaxin 13-positive endosomes.
Integrative strategies to identify candidate genes in rodent models of human alcoholism.
Treadwell, Ottawa, Canada. In Genome, 2006
In our study, 2 genes, retinaldehyde binding protein 1 (Rlbp1) and syntaxin 12 (Stx12), were found to be strong candidates for ethanol preference.
Molecular defects in the ABCA1 pathway affect platelet function.
Schambeck et al., Regensburg, Germany. In Pathophysiol Haemost Thromb, 2005
The ABCA1-NH2-terminus-associated Syntaxin-13, a SNARE complex protein, interacts with syntaxin 13-interacting protein (pallidin) whose deficiency leads to impaired platelet granule release from the dense granule Adapter Protein-3 (AP-3)-related pathway.
Genetic segregation of brain gene expression identifies retinaldehyde binding protein 1 and syntaxin 12 as potential contributors to ethanol preference in mice.
Singh et al., London, Canada. In Behav Genet, 2004
Potential role for Rlbp1 and Syntaxin 12 in ethanol preference in mice, a conclusion supported by the location of these genes in quantitative trait loci
Developmental and spatial expression pattern of syntaxin 13 in the mouse central nervous system.
Hirling et al., Lausanne, Switzerland. In Cell Tissue Res, 2002
the developmentally regulated syntaxin 13 expression in various neuronal populations is consistent with its involvement in endocytic trafficking and neurite outgrowth.
The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis.
Dell'Angelica et al., Los Angeles, United States. In Pigment Cell Res, 2002
The pallidin protein was found to bind to syntaxin 13, a member of the syntaxin family of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs).
The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency.
Gitschier et al., San Francisco, United States. In Nat Genet, 1999
In a yeast two-hybrid screen, we discovered that pallidin interacts with syntaxin 13, a t-SNARE protein that mediates vesicle-docking and fusion.
Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13.
Zerial et al., Heidelberg, Germany. In Cell, 1999
Syntaxin 13, the t-SNARE required for endosome fusion, is transiently incorporated into the large oligomers via direct interactions with EEA1.
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