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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Syndecan 4

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: syndecan-1, CAN, fibronectin, V1a, Actin
Papers using syndecan-4 antibodies
Syndecan-4–dependent Rac1 regulation determines directional migration in response to the extracellular matrix
Humphries Martin J. et al., In The Journal of Cell Biology, 2005
... Mouse monoclonal antibodies raised against vinculin (Sigma-Aldrich), syndecan-4 (clone 5G9; Santa Cruz Biotechnology, Inc.), and Rac1 and ...
Fibroblast growth factor–specific modulation of cellular response by syndecan-4
Simons Michael et al., In The Journal of Cell Biology, 1993
... Alternatively, the HA-tagged syndecan-4 cDNA constructs were inserted between the XhoI and EcoRI restriction sites of a bicistronic mammalian expression plasmid (pIRES2-EGFP; CLONTECH Laboratories) that coexpresses EGFP ...
Papers on syndecan-4
The Conserved Phenylalanine in the Transmembrane Domain Enhances Heteromeric Interactions of Syndecans.
Oh et al., Seoul, South Korea. In J Biol Chem, Feb 2016
Similarly, in an in vitro binding assay, a syndecan-2 mutant (S2(F169Y)) showed a significantly reduced interaction with syndecan-4.
Biochemical and toxicological evaluation of nano-heparins in cell functional properties, proteasome activation and expression of key matrix molecules.
Tsatsakis et al., Pátrai, Greece. In Toxicol Lett, Feb 2016
Moreover, nano-Styela regulates cell apoptosis, expression of inflammatory molecules, such as IL-6 and IL-8 and reduces the expression levels of extracellular matrix macromolecules, such as the proteolytic enzymes MT1-MMP, uPA and the cell surface proteoglycans syndecan-1 and -2, but not on syndecan-4.
MicroRNA regulation of myogenic satellite cell proliferation and differentiation.
Velleman et al., Wooster, United States. In Mol Cell Biochem, Jan 2016
Two genes essential to satellite cell function are syndecan-4 and glypican-1.
Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice.
Lunde et al., Oslo, Norway. In J Mol Cell Cardiol, Nov 2015
Innate immune signaling increases expression of the transmembrane proteoglycan syndecan-4 in cardiac myocytes and fibroblasts, followed by shedding of its ectodomain.
Development of Potent and Selective Tissue Transglutaminase Inhibitors: Their Effect on TG2 Function and Application in Pathological Conditions.
Griffin et al., Villeurbanne, France. In Chem Biol, Nov 2015
Reaction of TG2 with this fluorescent inhibitor in NIH3T3 cells resulted in loss of binding of TG2 to cell surface syndecan-4 and inhibition of translocation of the enzyme into the extracellular matrix, with a parallel reduction in fibronectin deposition.
Transmembrane proteoglycans control stretch-activated channels to set cytosolic calcium levels.
Couchman et al., Copenhagen, Denmark. In J Cell Biol, Oct 2015
In fibroblasts, ligand interactions with heparan sulfate of syndecan-4 recruit cytoplasmic protein kinase C to target serine714 of TRPC7 with subsequent control of the cytoskeleton and the myofibroblast phenotype.
The transmembrane heparan sulphate proteoglycan syndecan-4 is involved in establishment of the lamellar structure of the annulus fibrosus of the intervertebral disc.
Hayes et al., Cardiff, United Kingdom. In Eur Cell Mater, 2014
In this study, we investigate the role of two cell surface heparan sulphate proteoglycans (HSPGs), glypican-6 and syndecan-4, in the matrix assembly process in the developmental rat intervertebral disc.
Syndecan-4 shedding is involved in the oxidative stress and inflammatory responses in left atrial tissue with valvular atrial fibrillation.
Xu et al., Nanjing, China. In Int J Clin Exp Pathol, 2014
In addition, syndecan-4 (Synd4) shedding induced by oxidative stress or inflammation plays a role in the migration of inflammatory cells.
Role of Syndecans in Lipid Metabolism and Human Diseases.
Galzitskaya et al., Moscow, Russia. In Adv Exp Med Biol, 2014
Finally, syndecan-4 initiates the capture of modified low-density lipoproteins by macrophages and thereby promotes the atheroma formation.
Efficacy of antithrombin in preclinical and clinical applications for sepsis-associated disseminated intravascular coagulation.
Saitoh et al., Tokyo, Japan. In J Intensive Care, 2013
Meanwhile, AT also binds to syndecan-4 on the cell surface under physiological conditions, thereby contributing to local antithrombogenicity.
Syndecan-4 signaling at a glance.
Simons et al., New Haven, United States. In J Cell Sci, 2013
Syndecan-4, a ubiquitous cell surface proteoglycan, mediates numerous cellular processes through signaling pathways that affect cellular proliferation, migration, mechanotransduction and endocytosis.
Cell-matrix adhesion of podocytes in physiology and disease.
Sonnenberg et al., Amsterdam, Netherlands. In Nat Rev Nephrol, 2013
Other cell-matrix adhesion receptors expressed by podocytes include the integrins α2β1 and αvβ3, α-dystroglycan, syndecan-4 and type XVII collagen.
The role of syndecan-1 in cellular signaling and its effects on heparan sulfate biosynthesis in mesenchymal tumors.
Dobra et al., Stockholm, Sweden. In Front Oncol, 2012
This proteoglycan is often overexpressed in adenocarcinoma cells, whereas mesothelioma and fibrosarcoma cells express syndecan-2 and syndecan-4 more abundantly.
Expression of the proteoglycan syndecan-4 and the mechanism by which it mediates stress fiber formation in folliculostellate cells in the rat anterior pituitary gland.
Yashiro et al., Tochigi, Japan. In J Endocrinol, 2012
Expression of the proteoglycan syndecan-4 and the mechanism by which it mediates stress fiber formation in folliculostellate cells in the rat anterior pituitary gland.
Syndecan-4 and fibronectin in osteosarcoma.
Park et al., Seoul, South Korea. In Pathology, 2012
Increased expression of SDC4 and FN may be underlying molecular alteration of osteo-sarcoma which accounts for more aggressive clinical behaviour.
Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis.
Simons et al., Kyoto, Japan. In Sci Signal, 2012
studies identify S4 as a regulator of MAPK signaling and address the question of how distinct classes of FGFRs individually contribute to signal transduction in endothelial cells
Cell surface proteoglycans syndecan-1 and -4 bind overlapping but distinct sites in laminin α3 LG45 protein domain.
Rousselle et al., Lyon, France. In J Biol Chem, 2012
the LAMA3 LG45 domain may trigger different signals toward keratinocytes depending on its interaction with syndecan-1 or -4.
Syndecan-4 proteoliposomes enhance fibroblast growth factor-2 (FGF-2)-induced proliferation, migration, and neovascularization of ischemic muscle.
Baker et al., Cambridge, United States. In Proc Natl Acad Sci U S A, 2012
results support liposomal delivery of syndecan-4 as an effective means to improving the potential of using growth factors to achieve therapeutic neovascularization of ischemic tissue
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis.
Pap et al., Hannover, Germany. In Nat Med, 2009
The loss of syndecan-4 in genetically modified mice and intra-articular injections of syndecan-4-specific antibodies into wild-type mice prevent osteoarthritic cartilage damage in a surgically induced model of osteoarthritis.
Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos.
Larraín et al., Santiago, Chile. In Nat Cell Biol, 2006
Here, we have identified Xenopus syndecan-4 (xSyn4), a cell-surface transmembrane heparan sulphate proteoglycan.
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