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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Syndecan 3

Syndecan-3, synapsin III, syn3
The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, syndecan-1, V1a, HAD
Papers on Syndecan-3
Phosphorylation by PKA and Cdk5 Mediates the Early Effects of Synapsin III in Neuronal Morphological Maturation.
Giovedì et al., Genova, Italy. In J Neurosci, Oct 2015
Synapsin III (SynIII) is a neuron-specific phosphoprotein that plays a unique role in neuronal development.
Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanamines.
Wünsch et al., Münster, Germany. In Bioorg Med Chem, Sep 2015
The key steps in the synthesis of the diastereomeric propellanamines syn-3 and anti-3 are diastereoselective reduction of the ketone 7 with L-Selectride to give anti-11, Mitsunobu inversion of the alcohol anti-13 into syn-13, and SN2 substitution of diastereomeric mesylates syn-14 and anti-14 with NaN3.
α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons.
Bellucci et al., Brescia, Italy. In J Cell Sci, Aug 2015
The neuronal phosphoprotein synapsin III (also known as SYN3), is a pivotal regulator of dopamine neuron synaptic function.
Synapsin III acts downstream of semaphorin 3A/CDK5 signaling to regulate radial migration and orientation of pyramidal neurons in vivo.
Cancedda et al., Genova, Italy. In Cell Rep, May 2015
Synapsin III (SynIII) is a phosphoprotein that is highly expressed at early stages of neuronal development.
Syndecan-4 is a major syndecan in primary human endothelial cells in vitro, modulated by inflammatory stimuli and involved in wound healing.
Kolset et al., Tromsø, Norway. In J Histochem Cytochem, Apr 2015
qRT-PCR analysis revealed that syndecan-3 and syndecan-4 were highly expressed in HUVECs, whereas the expression of syndecan-1 and -2 was low.
Proteoglycans and neuronal migration in the cerebral cortex during development and disease.
Maeda, Tokyo, Japan. In Front Neurosci, 2014
Neuronal cell surface proteoglycans such as PTPζ, neuroglycan C and syndecan-3 function as direct receptors for heparin-binding growth factors that induce neuronal migration.
Association of OCT derived drusen measurements with AMD associated-genotypic SNPs in Amish population.
Stambolian et al., São Paulo, Brazil. In J Clin Med, 2014
Study subjects were further genotyped to determine their risk for the AMD associated SNPs in SYN3, LIPC, ARMS2, C3, CFB, CETP, CFI and CFH genes using TaqMan genotyping assays.
Syndecan-3 and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells.
Iversen et al., Oslo, Norway. In Plos One, 2014
Knock down of syndecan-3 in endothelial,- smooth muscle- and breast cancer cells reduced the TFPI surface levels by 20-50%, and an association of TFPIα to syndecan-3 on the cell surface was demonstrated.
Bevacizumab reduces neurocan content and gene expression in newborn rat retina in vitro.
Monteiro et al., São Paulo, Brazil. In Invest Ophthalmol Vis Sci, 2014
The purpose of this study was to investigate the effect of bevacizumab on neurocan, phosphacan, and syndecan-3 PG levels in newborn rat retina.
Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice.
Middleton et al., In Arthritis Res Ther, 2013
Syndecan-3 is expressed by synovial endothelial cells of rheumatoid arthritis (RA) patients where it binds chemokines, suggesting a role in leukocyte trafficking.
Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent manner.
Valtorta et al., Milano, Italy. In J Neurosci, 2012
Analysis of cultured neurons from wild-type and Syn I,II,III-deficient triple knock-out (TKO) mice shows that synaptic vesicles are severely dispersed in the absence of Syns.
The Arabidopsis SYN3 cohesin protein is important for early meiotic events.
Makaroff et al., Oxford, United States. In Plant J, 2012
Downregulation of SYN3 results in defects in chromosome synapsis and condensation during male and female meiosis.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Yaspo et al., Berlin, Germany. In J Biol Chem, 2011
SDC3 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
Synapsin III: role in neuronal plasticity and disease.
Kao et al., Providence, United States. In Semin Cell Dev Biol, 2011
Synapsin III was discovered in 1998, more than two decades after the first two synapsins (synapsins I and II) were identified.
Synapsins: from synapse to network hyperexcitability and epilepsy.
Baldelli et al., Genova, Italy. In Semin Cell Dev Biol, 2011
Single, double and triple synapsin knockout mice, with the notable exception of the synapsin III knockout mice, show a severe epileptic phenotype without gross alterations in brain morphology and connectivity.
Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin.
Saarma et al., Helsinki, Finland. In J Cell Biol, 2011
Syndecan-3 may directly transduce Glial cell line-derived neurotrophic factor (GDNF) family ligands (GFL) signals or serve as a coreceptor, presenting GFLs to the signaling receptor RET.
syn-1-Amino-3-[(18)F]fluorocyclobutane-1-carboxylic acid
Leung, Bethesda, United States. In Unknown Journal, 2010
In this chapter, syn-1-Amino-3-[(18)F]fluorocyclobutane-1-carboxylic acid (syn-3-[(18)F]FACBC) has also been synthesized and studied as a potential PET brain tumor imaging agent (10).
The role of syndecans in the regulation of body weight and synaptic plasticity.
Clegg et al., Cleveland, United States. In Int J Biochem Cell Biol, 2007
Syndecan-3, a member of the syndecan family of type I transmembrane heparan sulfate proteoglycans is a novel a regulator of feeding behavior and body weight.
Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3.
Bernfield et al., Boston, United States. In Cell, 2001
In wild-type mice, syndecan-3, the predominantly neural syndecan, is expressed in hypothalamic regions that control energy balance.
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