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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Synaptotagmin XI

synaptotagmin XI, SYT-11, KIAA0080, Syt XI, synaptotagmin 11
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: SYT-SSX, C2A, V1a, E3 ubiquitin ligase, HAD
Papers on synaptotagmin XI
Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.
Jaiswal et al., Washington, D.C., United States. In Cell Death Differ, Nov 2015
Deletion of one of the most abundant Syt isoform in astrocyte - Syt XI - suppresses astrocyte lysosome exocytosis.
Leishmania promastigotes induce cytokine secretion in macrophages through the degradation of synaptotagmin XI.
Descoteaux et al., Québec, Canada. In J Immunol, 2014
We recently discovered that Syt XI is a recycling endosome- and lysosome-associated protein that negatively regulates the secretion of TNF and IL-6.
Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic β-cells.
Lang et al., Pessac, France. In Febs Lett, 2014
Novel binding partners of synaptotagmin 11 were identified in β-cells.
Genetic variants of synaptic vesicle and presynaptic plasma membrane proteins in idiopathic generalized epilepsy.
Sözen et al., In J Recept Signal Transduct Res, 2014
BACKGROUND: The aim of this study was to analyze the role of the genetic variants of two synaptic vesicle proteins (VAMP2 and Synaptotagmin XI) and two presynaptic plasma membrane proteins (Syntaxin 1A and SNAP-25) in patients with idiopathic generalized epilepsy (IGE).
Synaptotagmin XI regulates phagocytosis and cytokine secretion in macrophages.
Descoteaux et al., Québec, Canada. In J Immunol, 2013
Given the importance of vesicular trafficking in macrophages, we investigated the role of Syt XI in cytokine secretion and phagocytosis.
Developmental expression and subcellular distribution of synaptotagmin 11 in rat hippocampus.
Lee et al., Seoul, South Korea. In Neuroscience, 2013
Previous reports suggested that the synaptotagmin 11 (syt11) gene is involved in the development of schizophrenia based on the genomic analysis of patients.
Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neurons.
Schneggenburger et al., Lausanne, Switzerland. In Mol Cell Neurosci, 2010
At postnatal days 12-15 these neurons expressed Syt-2 and Syt-11, and also Syt-3, -4, -7 and -13 at lower levels, whereas Syt-1 and -9 were absent.
Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brain.
Schoch et al., Bonn, Germany. In J Comp Neurol, 2009
We also show that Syt-11 is the major isoform expressed in astrocytes.
Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia.
Oishi et al., Kisarazu, Japan. In Am J Med Genet B Neuropsychiatr Genet, 2007
Excessive expression of Syt11 can be associated with schizophrenia.
Effects of methylation of non-CpG sequence in the promoter region on the expression of human synaptotagmin XI (syt11).
Oishi et al., Kisarazu, Japan. In Gene, 2005
We have studied the effects of methylation of the promoter region on the expression of human synaptotagmin XI (syt11), a gene implicated in the onset of schizophrenia.
Differential expression of striatal synaptotagmin mRNA isoforms in hemiparkinsonian rats.
Zivin et al., Ljubljana, Slovenia. In Neuroscience, 2004
On the 6-hydroxydopamine (6-OHDA)-lesioned side we observed a nearly total loss of tyrosine hydroxylase (TH), synaptotagmin I, Syt IV, Syt VII and Syt XI mRNA levels in the substantia nigra compacta (SNc).
Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain.
Patel et al., New York City, United States. In Protein Sci, 2004
Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain were identified using high-resolution crystal structures. have identified
Polymorphic 33-bp repeats with promoter-like activity in synaptotagmin 11 gene.
Oishi et al., Tochigi, Japan. In Dna Res, 2004
In the immediate upstream region of the transcription initiation site of human synaptotagmin 11 gene, we found a tandem repeat of a 33-bp unit with a promoter-like activity.
Screening for mutations in synaptotagmin XI in Parkinson's disease.
Riess et al., Tübingen, Germany. In J Neural Transm Suppl, 2003
Lack of disease-causing mutations in a detailed analysis of a large sample of familial and sporadic Parkinson's disease patients argues against a major role of mutations in the synaptotagmin XI gene in PD.
The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI.
Pulst et al., Los Angeles, United States. In Hum Mol Genet, 2003
parkin interacts with and ubiquitinates synaptotagmin XI
Effects of olmesartan, an angiotensin II receptor blocker, on mechanically-modulated genes in cardiac myocytes.
Shimada et al., Tochigi, Japan. In Cardiovasc Drugs Ther, 2003
RESULTS: Nine genes induced under 4% mechanical strain were significantly suppressed by RNH-6270 in rat cardiac myocytes: monoamine oxidase B, neuromedine B receptor, olfactory receptor, synaptotagmin XI, retinol-binding protein, and 4 expressed sequence tags (ESTs).
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