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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


Synaptopodin, SYNPO
may associate with actin to regulate cell shape; may play a role in synaptic plasticity [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Actin, Nephrin, alpha-actinin-4, NPHS2, alpha-Actinin
Papers on Synaptopodin
Exome Sequence Data From Multigenerational Families Implicate AMPA Receptor Trafficking in Neurocognitive Impairment and Schizophrenia Risk.
Almasy et al., San Antonio, United States. In Schizophr Bull, Oct 2015
From the gene SYNPO, rs6579797 (MAF = 0.032) shows significant associations with ABF (P = .015)
Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration.
Duncan et al., Halifax, Canada. In Oncotarget, Jun 2015
Synaptopodin-2 (Synpo2), an actin-binding protein and invasive cancer biomarker, induces formation of complex stress fiber networks in the cell body and promotes PC3 prostate cancer cell migration in response to serum stimulation.
Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia.
Cotter et al., Dublin, Ireland. In Mol Psychiatry, Apr 2015
Prominent among these were altered expression of proteins involved in clathrin-mediated endocytosis (CME) (Dynamin-1, adaptor protein 2) and N-methyl-D-aspartate (NMDA)-interacting proteins such as CYFIP2, SYNPO, SHANK3, ESYT and MAPK3 (all P<0.0015).
STAT3 regulates steady-state expression of synaptopodin in cultured mouse podocytes.
Dryer et al., Houston, United States. In Mol Pharmacol, Feb 2015
Synaptopodin (Synpo) is a cytoskeleton regulatory protein expressed in podocyte foot processes that regulates the dynamics of actin filaments and the stability of small GTPases.
Kinetics of Label Retaining Cells in the Developing Rat Kidneys.
Lue et al., Beijing, China. In Plos One, 2014
At 6 weeks, the EdU-labeled LRCs combined with expression of CD34, RECA-1, Nestin, and Synaptopodin were discretely but widely distributed within the glomeruli; Stro-1 around the glomeruli; and α-smooth muscle actin (SMA) in arteries.
Everolimus Stabilizes Podocyte Microtubules via Enhancing TUBB2B and DCDC2 Expression.
Weber et al., Essen, Germany. In Plos One, 2014
Interestingly, Tubb2bbrdp/brdp mice revealed a delay in glomerular podocyte development as showed by podocyte-specific markers Wilm's tumour 1, Podocin, Nephrin and Synaptopodin.
Systemic inflammation is associated with a reduction in Synaptopodin expression in the mouse hippocampus.
Vlachos et al., Frankfurt am Main, Germany. In Exp Neurol, 2014
Here, we addressed the question of whether systemic lipopolysaccharide (LPS)-induced inflammation influences the expression of Synaptopodin (SP).
Expression of synaptopodin in endothelial cells exposed to laminar shear stress and its role in endothelial wound healing.
Boo et al., Taegu, South Korea. In Febs Lett, 2014
Analysis of mRNA expression profiles of human umbilical vein endothelial cells under static and LSS-exposed conditions provided a list of LSS-induced actin binding proteins including synaptopodin (SYNPO) whose endothelial expression has not been previously reported.
Overexpression of Toll-like receptor 8 correlates with the progression of podocyte injury in murine autoimmune glomerulonephritis.
Kon et al., Sapporo, Japan. In Sci Rep, 2013
In BXSB-Yaa mice, the glomerular levels of Tlr8 mRNA negatively correlated with the glomerular levels of podocyte functional markers (Nphs1, Nphs2, and Synpo) and positively correlated with urinary albumin levels.
Early growth response 4 is involved in cell proliferation of small cell lung cancer through transcriptional activation of its downstream genes.
Katagiri et al., Tokushima, Japan. In Plos One, 2013
We identified four EGR4 target genes, SAMD5, RAB15, SYNPO and DLX5, which were the most significantly downregulated genes upon depletion of EGR4 expression in all of the SCLC cells examined, and demonstrated the direct recruitment of EGR4 to their promoters by ChIP and luciferase reporter analysis.
Podocyte injury caused by indoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand.
Kopp et al., Japan. In Plos One, 2013
After 8 w of indoxyl sulfate, podocytes showed foot process effacement, cytoplasmic vacuoles, and a focal granular and wrinkled pattern of podocin and synaptopodin expression.
The glomerular parietal epithelial cell's responses are influenced by SM22 alpha levels.
Shankland et al., Seattle, United States. In Bmc Nephrol, 2013
RESULTS: The number of PEC transition cells, defined as cells co-expressing a PEC protein (PAX2) and podocyte protein (Synaptopodin) was higher in diseased SM22α-/-mice compared with SM22α+/+mice.
Cellular effects of everolimus and sirolimus on podocytes.
Schwenger et al., Heidelberg, Germany. In Plos One, 2012
Synaptopodin and podocin expression was reduced as well as nephrin protein, particularly in the SRL group.
The role of Th17/IL-17 in the pathogenesis of primary nephrotic syndrome in children.
Tao et al., Chongqing, China. In Kidney Blood Press Res, 2012
Reverse transcription polymerase chain reaction was applied to measure the mRNA expressions of RORc, IL-23p19, Nephrin, WT1, Synaptopodin, Podocalyxin, Fas, and FasL.
Colocalization of α-actinin and synaptopodin in the pyramidal cell axon initial segment.
Muñoz et al., Madrid, Spain. In Cereb Cortex, 2012
Together, these results indicate that alpha-actinin and the actin cytoskeleton are important components of the cisternal organelle that are probably required to stabilize the AIS.
Synaptopodin and the spine apparatus organelle-regulators of different forms of synaptic plasticity?
Vlachos, Frankfurt am Main, Germany. In Ann Anat, 2012
Synaptopodin (SP) is an actin-binding molecule, which is closely linked with the spine apparatus organelle (SA).
Chronic corticosterone exposure alters postsynaptic protein levels of PSD-95, NR1, and synaptopodin in the mouse brain.
Arnold et al., Philadelphia, United States. In Synapse, 2011
Synpatopodin may play an important role in the changes of PSD-95 and NR1 protein levels and other synaptic alterations that are induced by corticosterone
Preservations of nephrin and synaptopodin by recombinant hepatocyte growth factor in podocytes for the attenuations of foot process injury and albuminuria in nephritic mice.
Nakamura et al., Suita, Japan. In Nephrology (carlton), 2011
HGF protects podocytes from a loss of nephrin, at least in part, through maintaining synaptopodin in nephritic mice with albuminuria.
Urinary podocyte-associated mRNA profile in various stages of diabetic nephropathy.
Liu et al., Nanjing, China. In Plos One, 2010
The urinary mRNA profiles of synaptopodin, podocalyxin, CD2-AP, alpha-actin4, and podocin were found to increase with the progression of diabetic nephropathy.
Regulation of podocyte BK(Ca) channels by synaptopodin, Rho, and actin microfilaments.
Dryer et al., Houston, United States. In Am J Physiol Renal Physiol, 2010
Podocyte BK(Ca) channels are regulated by synaptopodin, Rho, and actin microfilaments.
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