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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, cytokeratin, neuron-specific enolase
Papers using Synaptophysin antibodies
Injury and differentiation following inhibition of mitochondrial respiratory chain complex IV in rat oligodendrocytes
Lassmann Hans et al., In Brain, 2009
... SynaptophysinEpitomics YE269, Burlingame, CA, USA ...
A dynamically regulated 14-3-3, Slob, and Slowpoke potassium channel complex in Drosophila presynaptic nerve terminals
Nguyen Trung P. et al., In Journal of Neuroimmune Pharmacology, 1998
... Synaptophysin (SVP-38)Sigma Aldrich ...
Papers on Synaptophysin
PROX1 promotes secretory granule formation in medullary thyroid cancer cells.
Kamma et al., Kami-renjaku, Japan. In Endocrinology, Feb 2016
Knockdown of PROX1 in an MTC cells reduced SGs detected by electron microscopy, and decreased expression of SG-related genes (Chromogranin A, Chromogranin B, Secretogranin II, Secretogranin III, Synaptophysin and Carboxypeptidase E).
Synaptogenesis and Myelination in the Nucleus/Tractus Solitarius: Potential Role in Apnea of Prematurity, Congenital Central Hypoventilation, and Sudden Infant Death Syndrome.
Flores-Sarnat et al., Calgary, Canada. In J Child Neurol, Jan 2016
Synaptophysin demonstrated the immunocytochemical sequence of synaptogenesis.
Neurotrophin-dependent plasticity of neurotransmitter segregation in the rat superior cervical ganglion in vivo.
Morales et al., Mexico. In Dev Neurobiol, Dec 2015
Axotomy also increased the number of VAChT immunopositive varicosities, and caused the appearance of a population of VAChT-, mENK- or SV2-containing varicosities lacking Synaptophysin (Syn).
Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain.
Kim et al., Chinju, South Korea. In Neurochem Int, Nov 2015
We observed that chronic treatment of caffeine (3 mg/kg/day intraperitoneally (i.p) for 60 days) improved memory impairment and synaptic markers (Synaptophysin and PSD95) in the d-galactose treated rats.
Neurorestorative Therapy of Stroke in Type 2 Diabetes Mellitus Rats Treated With Human Umbilical Cord Blood Cells.
Chen et al., Tianjin, China. In Stroke, Sep 2015
HUCBC treatment significantly promoted white matter remodeling as indicated by increased expression of Bielschowsky silver (axons marker), Luxol fast blue (myelin marker), SMI-31 (neurofilament), and Synaptophysin in the ischemic border zone.
Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus.
Kim et al., Chinju, South Korea. In J Pineal Res, Aug 2015
After 24 hr of Aβ1-42 injection, the mice were treated with melatonin (10 mg/kg, intraperitonially) for 3 wks, reversed the Aβ1-42-induced synaptic disorder via increasing the level of presyanptic (Synaptophysin and SNAP-25) and postsynaptic protein [PSD95, p-GluR1 (Ser845), SNAP23, and p-CREB (Ser133)], respectively, and attenuated the Aβ1-42-induced memory impairment.
Large Cell Neuroendocrine Carcinoma of the Nasopharynx: A Pediatric Case.
Heymann et al., Nantes, France. In J Pediatr Hematol Oncol, Aug 2015
The immunohistochemical analysis showed a proliferation of large tumor cells stained with Chromogranin A and Synaptophysin.
[Glomus tumour of the lung: a case report and literature review].
Matute-Turizo et al., Cartagena, Colombia. In Cir Cir, Jul 2015
Synaptophysin, EMA and cytokeratin cocktail were negative, making the diagnosis of glomus tumour.
A resected case of neuroendocrine carcinoma of the stomach with unusual lymph node metastasis.
Yano et al., Fukuoka, Japan. In Med Mol Morphol, May 2015
The lymph node metastasis was positive not only for chromogranin A, but also for Synaptophysin and CD56.
Collision tumor of primary merkel cell carcinoma and chronic lymphocytic leukemia/small lymphocytic lymphoma, diagnosed on ultrasound-guided fine-needle aspiration biopsy: a unique case report and review of literature.
Wu et al., New York City, United States. In Diagn Cytopathol, 2015
Immunocytochemical studies of cell block sections revealed that the larger cells were positive for CD56, Chromogranin, Synaptophysin, CK8/18, CK20 (dot-like pattern); and the smaller cells were positive for CD45.
Characterizing synaptic protein development in human visual cortex enables alignment of synaptic age with rat visual cortex.
Murphy et al., Hamilton, Canada. In Front Neural Circuits, 2014
In this study, we quantified expression of a set of highly conserved pre- and post-synaptic proteins (Synapsin, Synaptophysin, PSD-95, Gephyrin) and found that synaptic development in human primary visual cortex (V1) continues into late childhood.
Pathology: Classification and Immunoprofile.
Perren et al., Bern, Switzerland. In Front Horm Res, 2014
Synaptophysin and chromogranin A are, to date, the most reliable and most commonly used for this purpose.
Intra-Amniotic LPS Induced Region-Specific Changes in Presynaptic Bouton Densities in the Ovine Fetal Brain.
Gavilanes et al., Maastricht, Netherlands. In Biomed Res Int, 2014
Synaptophysin immunohistochemistry was used to quantify the presynaptic density in layers 2-3 and 5-6 of the motor cortex, somatosensory cortex, entorhinal cortex, and piriforme cortex, in the nucleus caudatus and putamen and in CA1/2, CA3, and dentate gyrus of the hippocampus.
[Bronchial glomus tumor: report of 2 cases and review of the literature].
Tong et al., Beijing, China. In Zhonghua Jie He He Hu Xi Za Zhi, 2014
Immunohistochemically, cytokeratin (CK) was negative, while vimentin and CD34 vascular endothelial cell were positive, smooth muscle actin (SMA) weakly positive, and Synaptophysin partially positive in tumor cells.
Radial microcolumnar cortical architecture: maturational arrest or cortical dysplasia?
Flores-Sarnat et al., Calgary, Canada. In Pediatr Neurol, 2013
Synaptophysin demonstrates both radial and horizontal lamination of synaptic layers.
Chaperon normal goblet cells intercalated with dysplastic cells in duodenal adenomas express synaptophysin.
Ideström et al., Stockholm, Sweden. In Anticancer Res, 2012
Normal goblet cells found in duodenal adenomas express synaptophysin.
Genetic and functional analyses of the gene encoding synaptophysin in schizophrenia.
Chen et al., Taiwan. In Schizophr Res, 2012
The data of this study suggested that the common polymorphisms of the SYP gene appear not to play a major role in conferring susceptibility to schizophrenia.
Differences of molecular expression mechanisms among neural cell adhesion molecule 1, synaptophysin, and chromogranin A in lung cancer cells.
Yazawa et al., Yokohama, Japan. In Pathol Int, 2012
NCAM1, SYPT and CGA expressions are differently regulated by neuroendocrine phenotype-specific transcription factors in lung cancer cells.
Expression of PSA-NCAM and synaptic proteins in the amygdala of psychiatric disorder patients.
Nacher et al., Valencia, Spain. In J Psychiatr Res, 2012
The expression of synaptophysin and GAD67 was downregulated in the basolateral nucleus of schizophrenics.
Paneth cells and goblet cells express the neuroendocrine peptide synaptophysin. I. Normal duodenal mucosa.
Rubio, Stockholm, Sweden. In In Vivo, 2012
Finding that synaptophysin is produced by Paneth cells adds new information which might help to unravel the riddle of the ultimate biological significance of these puzzling cells.
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