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Synapsin II

synapsin II, syn-2, synapsin 2
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. The TIMP4 gene is located within an intron of this gene and is transcribed in the opposite direction. Mutations in this gene may be associated with abnormal presynaptic function and schizophrenia. Alternative splicing of this gene results in two transcripts. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, V1a, OUT, synapsin I
Papers on synapsin II
DABCO catalyzed domino Michael/hydroalkoxylation reaction involving α-alkynyl-β-aryl nitroolefins: excellent stereoselective access to dihydropyrano[3,2-c]chromenes, pyranonaphthoquinones and related heterocycles.
Samanta et al., Indore, India. In Org Biomol Chem, Feb 2016
Moreover, syn-2-benzyl-4-aryl-3,4-dihydropyrano[3,2-c]chromenes were obtained in high yields (81-86%) via a stereoselective denitrohydrogenation of the corresponding 2-benzylidene-3,4-dihydropyrano[3,2-c]chromenes using a catalytic amount of 10% Pd/C.
Functions of synapsins in corticothalamic facilitation: important roles of synapsin I.
Heggelund et al., Oslo, Norway. In J Physiol, Nov 2015
ABSTRACT: The synaptic vesicle associated proteins synapsin I (SynI) and synapsin II (SynII) have important functions in several types of synaptic short-term plasticity in the brain, but their separate functions in different types of synapses are not well known.
Responses of Cerambycidae and Other Insects to Traps Baited With Ethanol, 2,3-Hexanediol, and 3,2-Hydroxyketone Lures in North-Central Georgia.
Sweeney et al., Fredericton, Canada. In J Econ Entomol, Oct 2015
In north-central Georgia, 13 species of woodboring beetles (Coleoptera: Cerambycidae: Cerambycinae) were attracted to multiple-funnel traps baited with ethanol and one of the following pheromones: (1) racemic 3-hydroxyhexan-2-one; (2) racemic 3-hydroxyoctan-2-one; and (3) syn-2,3-hexanediol.
Role of presynaptic phosphoprotein synapsin II in schizophrenia.
Mishra et al., Hamilton, Canada. In World J Psychiatry, Oct 2015
Synapsin II is a member of the neuronal phosphoprotein family.
Candidate Attractant Pheromones of Two Potentially Invasive Asian Cerambycid Species in the Genus Xylotrechus.
Millar et al., Izumo, Japan. In J Econ Entomol, Jun 2015
Furthermore, more than 200 males and females of the congener Xylotrechus rufilius Bates were attracted by racemic 2-hydroxyoctan-3-one, and inhibited by syn-2,3-octanediol.
Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2.
Ekdahl et al., Lund, Sweden. In Plos One, 2014
Here, we evaluated brain inflammation, synaptic protein expression, and adult hippocampal neurogenesis in the epileptogenic (1 and 2 months of age) and tonic-clonic (3.5-4 months) phase of synapsin 2 knockout mice using immunohistochemical and biochemical assays.
Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent manner.
Valtorta et al., Milano, Italy. In J Neurosci, 2012
Analysis of cultured neurons from wild-type and Syn I,II,III-deficient triple knock-out (TKO) mice shows that synaptic vesicles are severely dispersed in the absence of Syns.
Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.
Tsujimoto et al., Kyoto, Japan. In Febs Lett, 2012
Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 linking to G??-PLC?3-ERK1/2-synapsin 2
Synapsins I and II are not required for insulin secretion from mouse pancreatic β-cells.
Eliasson et al., Malmö, Sweden. In Endocrinology, 2012
We conclude that neither synapsin I nor synapsin II are directly involved in the regulation of glucose-stimulated insulin secretion and Ca(2)-dependent exocytosis in mouse pancreatic beta-cells.
Synapsin II is involved in the molecular pathway of lithium treatment in bipolar disorder.
Turecki et al., Montréal, Canada. In Plos One, 2011
Synapsin II is involved in the molecular pathway of lithium treatment in bipolar disorder
A new kinetic framework for synaptic vesicle trafficking tested in synapsin knock-outs.
Wesseling et al., Pamplona, Spain. In J Neurosci, 2011
The supply rate of vesicle trafficking depresses more rapidly in synapsin knock-outs; the phenotype can be fully explained by changing the value of the single parameter in the model that would specify the size of the local reserve pools.
Synapsin regulation of vesicle organization and functional pools.
Bykhovskaia, Bayamón, Puerto Rico. In Semin Cell Dev Biol, 2011
Synapsin directs vesicles into the reserve pool, and synapsin II isoform has a primary role in this function.
[Natural products syntheses based on the biotransformation using biocatalyst].
Akita, In Yakugaku Zasshi, 2011
Asymmetric reduction of 2-methyl-3-keto ester with yeast gave the optically active syn-2-methyl-3-hydroxy ester, which was converted to natural product such as (-)-oudemansin B. Asymmetric hydrolysis of 3-acetoxy-2-methy esters possessing syn- or anti-structure afforded the optically active 3-hydroxy-2-methyl esters and 3-acetoxy-2-methy esters corresponding to the starting material.
SmI2-induced cyclizations and their applications in natural product synthesis.
Nakata, Tokyo, Japan. In Chem Rec, 2010
We have developed SmI(2)-induced cyclization of beta-alkoxyacrylate with aldehyde, affording 2,6-syn-2,3-trans-tetrahydropyran (THP) or 2,7-syn-2,3-trans-oxepane with complete stereoselection, as a key reaction of efficient iterative and bi-directional strategies for the construction of these polycyclic ethers.
Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study.
Goldstein et al., Dublin, Ireland. In Lancet Neurol, 2007
Variations in the genes KCNAB1, GABRR2, KCNMB4, SYN2, and ALDH5A1 were most notable.
RIM1alpha is required for presynaptic long-term potentiation.
Malenka et al., Stanford, United States. In Nature, 2002
Studies of knockout mice have shown that the synaptic vesicle protein Rab3A is required for mossy fibre LTP, but the protein kinase A substrates rabphilin, synapsin I and synapsin II are dispensable.
Essential functions of synapsins I and II in synaptic vesicle regulation.
Südhof et al., Dallas, United States. In Nature, 1995
To analyse the functions of these proteins, we have studied knockout mice lacking either synapsin I, synapsin II, or both.
Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons.
Han et al., Boston, United States. In Science, 1994
Synapsin I and synapsin II are neuron-specific phosphoproteins that have a role in the regulation of neurotransmitter release and in the formation of nerve terminals.
Synapsin I, synapsin II, and synaptophysin: marker proteins of synaptic vesicles.
Thiel, Köln, Germany. In Brain Pathol, 1993
The nerve terminal of neurons is filled with small synaptic vesicles, specialized secretory organelles involved in the storage and release of neurotransmitters.
The synapsins and the regulation of synaptic function.
Greengard et al., New York City, United States. In Bioessays, 1990
The high degree of homology between the synapsins suggests that some of the functional properties of synapsin I are also shared by synapsin II.
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