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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Synapsin I

synapsin I, SYN1, synapsin 1
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Synaptophysin, HAD, ACID, CaM
Papers using synapsin I antibodies
Inferior parietal lobule projections to anterior inferotemporal cortex (area TE) in macaque monkey
Rockland Kathleen S. et al., In Frontiers in Neuroanatomy, 2002
... = 2); and a newly developed adenovirus, generated by using a neuron-specific promoter synapsin 1 and an enhanced green fluorescent protein (EGFP) reporter (AdSynEGFP; Tomioka and Rockland, ...
A dynamically regulated 14-3-3, Slob, and Slowpoke potassium channel complex in Drosophila presynaptic nerve terminals
Nguyen Trung P. et al., In Journal of Neuroimmune Pharmacology, 1998
... Synapsin 1Abcam ...
Autolytic transition of mu-calpain upon activation as resolved by antibodies distinguishing between the pre- and post-autolysis forms.
Okazawa Hitoshi, In PLoS ONE, 1991
... Temecula, CA), mouse anti-Tuj1 (1∶2000, Covance, Princeton, NJ), rabbit anti-GFAP (1∶500, DAKO, Carpinteria, CA), rabbit anti-Synapsin I (1∶500, Millipore), mouse anti-Cux1 (1∶100, Abnova, Taipei, Taiwan), rabbit anti-Satb2 ...
Papers on synapsin I
Clozapine Improves Memory Impairment and Reduces Aβ Level in the Tg-APPswe/PS1dE9 Mouse Model of Alzheimer's Disease.
Jeon et al., South Korea. In Mol Neurobiol, Feb 2016
Moreover, clozapine-phosphorylated synapsin I at Ser9 and Ser549 sites in the hippocampus and cortex of AD mice, which may be involved in synaptic strength.
The Nanoscale Observation of the Three-Dimensional Structures of Neurosynapses, Membranous Conjunctions Between Cultured Hippocampal Neurons and Their Significance in the Development of Epilepsy.
Yu et al., Beijing, China. In Mol Neurobiol, Jan 2016
The neurons and dendrites were marked by MAP-2, axons by neurofilament 200, and synapses by synapsin I immunological staining.
Ganglioside GQ1b induces dopamine release through the activation of Pyk2.
Chen et al., Beijing, China. In Mol Cell Neurosci, Jan 2016
Further studies revealed that activated Pyk2 stimulated ERK1/2 and p-38, while only the ERK1/2 activation was indispensable for GQ1b induced DA release, which interacted with Synapsin I directly and led to its phosphorylation, then depolymerization of F-actin, thus contributed to DA release.
GABAergic Agonists Modulate the Glutamate Release from Frontal Cortex Synaptosomes of Rats with Experimental Autoimmune Encephalomyelitis.
Roth et al., Córdoba, Argentina. In Inflamm Allergy Drug Targets, Jan 2016
In order to explore the possible metabolic pathways responsible for this alteration, in this work we evaluate the direct effect of different GABAergic agonists on the glutamate release and concomitant synapsin I phosphorylation in synaptosomes from the frontal cortex of control and EAE animals.
Glutamate Release.
Ueda et al., Charlottesville, United States. In Neurochem Res, Dec 2015
Glutamate-loaded vesicles undergo removal of Synapsin I by CaM kinase II-mediated phosphorylation, transforming to the release-ready pool.
Effects of high-fructose diets on central appetite signaling and cognitive function.
Vanden Berghe et al., Leuven, Belgium. In Front Nutr, 2014
On the other hand, it appears to impact on cognitive function by affecting phosphorylation levels of insulin receptor, synapsin 1, and synaptophysin.
Platelet Activating Factor Enhances Synaptic Vesicle Exocytosis Via PKC, Elevated Intracellular Calcium, and Modulation of Synapsin 1 Dynamics and Phosphorylation.
Gelbard et al., Rochester, United States. In Front Cell Neurosci, 2014
Furthermore, cPAF increases synapsin I phosphorylation at sites 1 and 3, and increases dispersion of synapsin I from the presynaptic compartment during stimulation, freeing synaptic vesicles for subsequent release.
Omega-3 Fatty acids could alleviate the risks of traumatic brain injury - a mini review.
Manivasagam et al., Oman. In J Tradit Complement Med, 2014
BDNF improves the synaptic transmission by regulating synapsin 1 and cyclic adenosine monophosphate (cAMP) response element binding protein.
Epilepsy associated with autism and attention deficit hyperactivity disorder: is there a genetic link?
Curatolo et al., Roma, Italy. In Brain Dev, 2014
The majority of the candidate genes are involved in synaptic formation/remodeling/maintenance (NRX1, CNTN4, DCLK2, CNTNAP2, TRIM32, ASTN2, CTNTN5, SYN1), neurotransmission (SYNGAP1, GABRG1, CHRNA7), or DNA methylation/chromatin remodeling (MBD5).
Decreased expression of synapse-related genes and loss of synapses in major depressive disorder.
Duman et al., New Haven, United States. In Nat Med, 2012
Here we use microarray gene profiling and electron microscopic stereology to reveal lower expression of synaptic-function–related genes (CALM2, SYN1, RAB3A, RAB4B and TUBB4) in the dlPFC of subjects with MDD and a corresponding lower number of synapses.
SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function.
Cossette et al., Genova, Italy. In Hum Mol Genet, 2011
SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function.
Glutamatergic neurotransmission in the synapsin I and II double knock-out mouse.
Walaas et al., Oslo, Norway. In Semin Cell Dev Biol, 2011
We here briefly describe the important characteristics of the synapsin proteins, and review recent studies on transgenic mice devoid of the gene products encoded by the synapsin I and II genes, where both neurochemical, cell biological and electrophysiological methods have been employed.
Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression.
Wang et al., Hefei, China. In J Biol Chem, 2011
the nucleocytoplasmic shuttling of dysbindin-1 regulates synapsin I expression and thus may be involved in the pathogenesis of schizophrenia.
Cellular site and molecular mode of synapsin action in associative learning.
Gerber et al., Würzburg, Germany. In Learn Mem, 2010
This study synapsin acts in associative memory trace formation in the mushroom bodies, as a downstream element of AC-cAMP-PKA signaling.
A role for syndecan-1 and claudin-2 in microbial translocation during HIV-1 infection.
Haase et al., Minneapolis, United States. In J Acquir Immune Defic Syndr, 2010
The authors propose claudin-2 and SYN1 work in concert to enhance microbial translocation across the intestinal epithelial barrier to contribute to chronic immune activation and CD4 T-cell depletion in HIV-1-infected patients.
Synapsin regulates vesicle organization and activity-dependent recycling at Drosophila motor boutons.
Bykhovskaia et al., Bethlehem, United States. In Neuroscience, 2010
these results elucidate a novel synapsin function, specifically, promoting vesicle reuptake and reserve pool formation upon intense stimulation.
Creation of a bacterial cell controlled by a chemically synthesized genome.
Venter et al., Rockville, United States. In Science, 2010
We report the design, synthesis, and assembly of the 1.08-mega-base pair Mycoplasma mycoides JCVI-syn1.0
Neurofibromin regulation of ERK signaling modulates GABA release and learning.
Silva et al., Los Angeles, United States. In Cell, 2008
Our results demonstrate that neurofibromin modulates ERK/synapsin I-dependent GABA release, which in turn modulates hippocampal LTP and learning.
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation.
Shi et al., Boston, United States. In Nature, 2007
RNA-interference-mediated depletion of SMCX derepresses several of these targets and simultaneously increases H3K4 trimethylation at the sodium channel type 2A (SCN2A) and synapsin I (SYN1) promoters.
RIM1alpha is required for presynaptic long-term potentiation.
Malenka et al., Stanford, United States. In Nature, 2002
Studies of knockout mice have shown that the synaptic vesicle protein Rab3A is required for mossy fibre LTP, but the protein kinase A substrates rabphilin, synapsin I and synapsin II are dispensable.
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