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Spleen tyrosine kinase

Syk, spleen tyrosine kinase
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: CAN, V1a, Src, BCR, Akt
Papers using Syk antibodies
CLEC-2 activates Syk through dimerization
Heemskerk Johan W. M. et al., In Cellular and Molecular Life Sciences, 2009
... Dimethyl BAPTA (DM-BAPTA), Fura-2 and Fura-Red acetoxymethyl esters were from Molecular Probes, while Syk inhibitor II and IV were from Merck Biosciences ...
Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2, 3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets.
Schulz Christian, In PLoS ONE, 2007
... Phospho-specific antibodies against Y416 Src family, anti-Syk Y525/526, Total Src and Total Syk were obtained from Cell Signaling Technologies (Beverly, MA) ...
Integrin α2β1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCγ2
Watson Steve P. et al., In The Journal of Cell Biology, 2001
... Anti-FAK pAb (C-903) and anti-Syk pAb (LR) for immunoprecipitation and anti-Syk mAb (4D10) for Western blotting were from Santa Cruz Biotechnology, Inc ...
LAT palymitoylationits essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
Oliver Janet M. et al., In The Journal of Cell Biology, 1997
... Rabbit anti-Lyn (44) and anti-Syk (N-19) Abs were from Santa Cruz Biotechnology, Inc ...
Killer cell inhibitory receptor recognition of human leukocyte antigen (HLA) class I blocks formation of a pp36/ PLC-γ signaling complex in human natural killer (NK) cells
Leibson Paul J. et al., In The Journal of Experimental Medicine, 1995
... The 4D10 mAb specific for Syk was purchased from Santa Cruz Biotechnology ...
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Papers on Syk
High-resolution antibody array analysis of childhood acute leukemia cells.
Kalina et al., Praha, Czech Republic. In Mol Cell Proteomics, Feb 2016
From non-CD markers, we found DBN1, PAX5, or PTK2 overexpressed in B-cell precursor acute lymphoblastic leukemias, LAT, SH2D1A, or STAT5A overexpressed in T-cell acute lymphoblastic leukemias, and HCK, GLUD1, or SYK overexpressed in acute myeloid leukemias.
A role for spleen tyrosine kinase in renal fibrosis in the mouse obstructed kidney.
Nikolic-Paterson et al., Australia. In Life Sci, Feb 2016
AIMS: Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase involved in the signalling pathways of the B cell receptor, Fcγ-receptor and some leukocyte integrins.
Resveratrol preferentially inhibits IgE-dependent PGD2 biosynthesis but enhances TNF production from human skin mast cells.
Gomez et al., Columbia, United States. In Biochim Biophys Acta, Feb 2016
Accordingly, COX-2 expression was inhibited but phosphorylation of Syk, Akt, p38, and p42/44 (ERKs) remained intact.
Ikaros limits follicular B cell activation by deregulating B cell receptor signaling pathways.
Kastner et al., Illkirch-Graffenstaden, France. In Biochem Biophys Res Commun, Feb 2016
Unstimulated mutant B cells show deregulation of positive and negative regulators of signal transduction at the mRNA level, and constitutive phosphorylation of ERK, p38, SYK, BTK, AKT and LYN.
Platelet immunoreceptor tyrosine-based activation motif (ITAM) and hemITAM signaling and vascular integrity in inflammation and development.
Bergmeier et al., Chapel Hill, United States. In J Thromb Haemost, Feb 2016
These receptors share common downstream effectors including Syk, SLP-76 and PLCγ2.
Targeted therapies for CLL: Practical issues with the changing treatment paradigm.
O'Brien et al., Houston, United States. In Blood Rev, Jan 2016
These include B-cell receptor (BCR) inhibitors such as Bruton tyrosine kinase (BTK) inhibitors, PI3 kinase inhibitors, and Syk inhibitors, novel anti-CD20 monoclonal antibodies such as ofatumumab and obinutuzumab, and Bcl-2 antagonists such as venetoclax (ABT-199).
The role of B-cell receptor inhibitors in the treatment of patients with chronic lymphocytic leukemia.
Wiestner, Bethesda, United States. In Haematologica, Dec 2015
Spleen tyrosine kinase, Bruton's tyrosine kinase, and the phosphatidylinositol 3-kinase (PI3K) δ isoform are essential for B-cell receptor signal transduction but also mediate the effect of other pathways engaged in chronic lymphocytic leukemia cells in the tissue-microenvironment. Orally bioavailable inhibitors of spleen tyrosine kinase, Bruton's tyrosine kinase, or PI3Kδ, induce high rates of durable responses.
Targeting Bruton's tyrosine kinase signaling as an emerging therapeutic agent of B-cell malignancies.
Zhang et al., Tianjin, China. In Oncol Lett, Dec 2015
These inhibitors include spleen tyrosine kinase, mammalian target of rapamycin, phosphoinositide 3'-kinase and Bruton's tyrosine kinase (BTK).
Spleen Tyrosine Kinase Confers Paclitaxel Resistance in Ovarian Cancer.
Birrer et al., Boston, United States. In Cancer Cell, Aug 2015
In this issue of Cancer Cell, Yu and colleagues describe the critical role of spleen tyrosine kinase (SYK) in paclitaxel resistance by modulating the stability of microtubules.
Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules.
Shih et al., Baltimore, United States. In Cancer Cell, Aug 2015
We report that recurrent ovarian carcinomas after paclitaxel/carboplatin treatment have higher levels of spleen tyrosine kinase (SYK) and phospho-SYK.
Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.
Xiao et al., Shanghai, China. In Nat Immunol, Jun 2015
Fungal infection stimulates the canonical C-type lectin receptor (CLR) signaling pathway via activation of the tyrosine kinase Syk.
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.
Müschen et al., San Francisco, United States. In Nature, Jun 2015
Here we find, by testing various components of proximal pre-BCR signalling in mouse BCR-ABL1 cells, that an incremental increase of Syk tyrosine kinase activity was required and sufficient to induce cell death.
Epigenetic modification and antibody-dependent expansion of memory-like NK cells in human cytomegalovirus-infected individuals.
Kim et al., East Lansing, United States. In Immunity, Apr 2015
Here, we have shown that HCMV-infected individuals have several distinct subsets of memory-like NK cells that are often deficient for multiple transcription factors and signaling proteins, including tyrosine kinase SYK, for which the reduced expression was stable over time and correlated with epigenetic modification of the gene promoter.
The importance of B cell-T cell interaction in autoimmune diseases.
Tanaka et al., In Nihon Rinsho Meneki Gakkai Kaishi, 2014
We found that combination with BCR, CD40 and TLR9 or IL-4/IL-21 signal via tyrosine kinases such as Syk/Btk/JAK caused robust gene expression of AICDA, BCL6, XBP1 and IgG production.
Disturbed T Cell Signaling and Altered Th17 and Regulatory T Cell Subsets in the Pathogenesis of Systemic Lupus Erythematosus.
van der Vlag et al., Nijmegen, Netherlands. In Front Immunol, 2014
In particular, defects in the TCRζ chain, Syk kinase, and calcium signaling molecules have been associated with SLE, which leads to hyperresponsive autoreactive T cells.
Spleen tyrosine kinase mediates high glucose-induced transforming growth factor-β1 up-regulation in proximal tubular epithelial cells.
Park et al., Seoul, South Korea. In Exp Cell Res, 2012
high glucose-induced TGF-beta1 gene transcription occurred through Pak2, Syk and subsequent ERK/AP-1 and NF-kappaB pathways
Identification of novel SNPs in SYK gene of breast cancer patients: computational analysis of SNPs in the 5'UTR.
Faryal et al., Islamabad, Pakistan. In Mol Biol Rep, 2012
Seven novel SYK gene SNPs were identified in breast cancer patients.
The C-type lectin receptor CLECSF8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through Syk kinase.
Brown et al., Cape Town, South Africa. In J Biol Chem, 2012
CLECSF8 functions as an activation receptor on myeloid cells and induces signaling via Syk kinase
Subthreshold desensitization of human basophils re-capitulates the loss of Syk and FcεRI expression characterized by other methods of desensitization.
MacGlashan, Baltimore, United States. In Clin Exp Allergy, 2012
IL-3 modifies only the sensitivity of signalling elements that are downstream of syk activation.
HIV delays IFN-α production from human plasmacytoid dendritic cells and is associated with SYK phosphorylation.
Ostrowski et al., Toronto, Canada. In Plos One, 2011
HIV delays pDC IFN-alpha production and pDC activation via SYK phosphorylation
More papers using Syk antibodies
Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases
Korenbrot Juan I. et al., In The Journal of Cell Biology, 1992
... Phospho-Src family (P-Y416) and phospho–Zap-70 (P-Y319)/Syk (P-Y352) antibodies were purchased from Cell Signaling Technology ...
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