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Intersectin 2

Swap, ITSN2, intersectin 2, SFRS8
This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: intersectin, Actin, CAN, 70-kDa, HAD
Papers using Swap antibodies
Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity
Martín-Belmonte Fernando et al., In The Journal of Cell Biology, 2007
... Antibodies against ITSN2 (Novus Biologicals), N-WASP (Santa Cruz Biotechnology, ...
Papers on Swap
Aging with ING: a comparative study of different forms of stress induced premature senescence.
Riabowol et al., Calgary, Canada. In Oncotarget, Nov 2015
ING1a induces expression of intersectin 2, a scaffold protein necessary for endocytosis, altering the stoichiometry of endocytosis proteins, subsequently blocking growth factor uptake leading to activation of Rb signaling to block cell growth.
A Charge Swap mutation E461K in the yeast dynamin Vps1 reduces endocytic invagination.
Ayscough et al., Durham, United Kingdom. In Commun Integr Biol, Jul 2015
Vps1 is the yeast dynamin-like protein that functions during several membrane trafficking events including traffic from Golgi to vacuole, endosomal recycling and endocytosis.
Intersectin adaptor proteins are associated with actin-regulating protein WIP in invadopodia.
Rynditch et al., Ukraine. In Cell Signal, Jul 2015
Here we show that WIP interacts with endocytic adaptor proteins of the intersectin (ITSN) family, ITSN1 and ITSN2.
Unraveling the Rat Intestine, Spleen and Liver Genome-Wide Transcriptome after the Oral Administration of Lavender Oil by a Two-Color Dye-Swap DNA Microarray Approach.
Shioda et al., Tokyo, Japan. In Plos One, 2014
The rats were administered LO at 5 mg/kg (usual therapeutic dose in humans) followed by the screening of differentially expressed genes in the tissues, using a 4×44-K whole-genome rat chip (Agilent microarray platform; Agilent Technologies, Palo Alto, CA, USA) in conjunction with a dye-swap approach, a novelty of this study.
The consequences of reconfiguring the ambisense S genome segment of Rift Valley fever virus on viral replication in mammalian and mosquito cells and for genome packaging.
Elliott et al., Saint Andrews, United Kingdom. In Plos Pathog, 2014
Using reverse genetics we generated a virus, designated rMP12:S-Swap, in which the N protein is expressed from the NSs locus and NSs from the N locus within the genomic S RNA.
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.
Sivils et al., Oklahoma City, United States. In Nat Genet, 2013
We also observed suggestive associations (Pmeta < 5 × 10(-5)) with variants in 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others.
Evaluation of Expression of Lipases and Phospholipases of Malassezia restricta in Patients with Seborrheic Dermatitis.
Jung et al., Seoul, South Korea. In Ann Dermatol, 2013
METHODS: Swap samples of two different body sites of at least 18 patients with seborrheic dermatitis were obtained and in vivo expression of lipases and phospholipases of M. restricta was analyzed by the gene specific two-step nested RT-PCR.
The effect of clozapine on mRNA expression for genes encoding G protein-coupled receptors and the protein components of clathrin-mediated endocytosis.
Gurling et al., London, United Kingdom. In Psychiatr Genet, 2013
RESULTS: The expression of genes encoding adaptor and clathrin assembly proteins, AP2A2, AP2B1, AP180, CLINT1, HIP1, ITSN2, and PICALM, increased relative to the control in SH-SY5Y cells incubated with 5-10 µmol/l clozapine for 24-72 h.
SWAP-70 restricts spontaneous maturation of dendritic cells.
Jessberger et al., Dresden, Germany. In J Immunol, 2013
We found that the absence of SWAP-70 causes spontaneous maturation of spleen- and bone marrow-derived DCs and, in vivo, of spleen-resident CD11c(+)CD11b(+)CD8α(-) DCs.
Control of the STAT6-BCL6 antagonism by SWAP-70 determines IgE production.
Jessberger et al., Dresden, Germany. In J Immunol, 2013
The switch to IgE depends on IL-4, which stimulates GLT of the Iε promoter, but is specifically and strongly impaired in Swap-70(-/-) mice.
Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.
Rynditch et al., Ukraine. In Plos One, 2012
BACKGROUND: Scaffolding proteins of the intersectin (ITSN) family, ITSN1 and ITSN2, are crucial for the initiation stage of clathrin-mediated endocytosis.
The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway.
Riabowol et al., Calgary, Canada. In Plos Biol, 2012
Intersectin 2 (ITSN2) is most affected by ING1a, being rapidly induced >25-fold.
The homeodomain region controls the phenotype of HOX-induced murine leukemia.
Slany et al., Erlangen, Germany. In Blood, 2012
Swap experiments between HOXA1 and HOXA9, 2 members of nonrelated paralog groups, revealed that gene expression patterns of HOX transformed cells in vitro are determined by the nature of the homeodomain.
Identification of a novel function of the clathrin-coated structure at the plasma membrane in facilitating GM-CSF receptor-mediated activation of JAK2.
Yen et al., Taipei, Taiwan. In Cell Cycle, 2012
Knockdown expression of clathrin heavy chain or intersectin 2 (ITSN2) attenuated GMR-mediated activation of JAK2, whereas inhibiting clathrin-coated pits or plagues to bud off the membrane by the dominant-negative mutant of dynamin enhanced such event.
Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.
Wagner et al., Regensburg, Germany. In Plos One, 2011
Thereby we identified five new (from intersectin 2, the osteoclast stimulating factor OSF, nephrocystin, sorting nexin 9, and CIN85) and seven already known high-confidence Sam68-ligands (mainly from the Src-kinase family), as well as several lower-affinity binders.
Intersectin-2L regulates caveola endocytosis secondary to Cdc42-mediated actin polymerization.
Predescu et al., Chicago, United States. In J Biol Chem, 2009
ITSN-2L, a guanine nucleotide exchange factor for Cdc42, regulates different steps of caveola endocytosis in ECs by controlling the temporal and spatial actin polymerization and remodeling sub-adjacent to the plasma membrane.
The K15 protein of Kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective SH3 domain interaction.
Pawson et al., Toronto, Canada. In Biochemistry, 2007
We show that the PPLP motif of K15 protein selectively binds the SH3-C domain of an endocytic adaptor protein, Intersectin 2 (ITSN2).
Expression analysis of human intersectin 2 gene (ITSN2) minor splice variants showing differential expression in normal human brain.
Welter et al., Homburg, Germany. In Oncol Rep, 2007
ITSN2C may be specifically expressed in neurons hinting to a physiologic role in neuronal cell function.
Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2.
Kaibuchi et al., Nagoya, Japan. In Mol Biol Cell, 2006
These results highlight a role of Numb for dendritic spine development and synaptic functions with intersectin and EphB2.
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