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Suppressor of zeste 12 homolog

SUZ12, JJAZ1, KIAA0160
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009] (from NCBI)
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Top mentioned proteins: Polycomb, EZH2, Histone, EED, JAZF1
Papers using SUZ12 antibodies
p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor
Dilworth Francis Jeffrey et al., In The EMBO Journal, 1998
... include H3K4me3 (Abcam ab8580), H3K27me3 (Abcam ab6002), H3 antibody (Millipore 06-755), Myog (Santa Cruz SC-576), Suz12 (Abcam ab12073), Mef2 (Santa Cruz ...
Papers on SUZ12
Histone Deacetylase 1 (HDAC1) Negatively Regulates Thermogenic Program in Brown Adipocytes via Coordinated Regulation of H3K27 Deacetylation and Methylation.
Xue et al., United States. In J Biol Chem, Feb 2016
This is followed by dissociation of the polycomb repressive complexes, including the H3K27 methyltransferase enhancer of zeste homologue (EZH2), suppressor of zeste 12 (SUZ12), and ring finger protein 2 (RNF2) from, and concomitant recruitment of H3K27 demethylase ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX) to UCP1 and PGC1α promoters, leading to decreased H3K27 trimethylation, a histone transcriptional repression mark.
Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics.
Hornick et al., Boston, United States. In Mod Pathol, Jan 2016
Inactivation of the polycomb repressive complex 2 (PRC2), resulting from inactivating mutations of its constituents SUZ12 or EED1, has recently been identified in 70-90% of malignant peripheral nerve sheath tumors.
Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNST.
Antonescu et al., Tampa, United States. In Am J Surg Pathol, Jan 2016
Mutations in EED and SUZ12 induce loss of trimethylation at lysine 27 of histone 3 (H3K27me3), with subsequent aberrant transcriptional activation of polycomb repressive complex 2-repressed homeobox master regulators.
PRC2 mediated H3K27 methylations in cellular identity and cancer.
Bracken et al., Dublin, Ireland. In Curr Opin Cell Biol, Dec 2015
It is composed of a trimeric core of SUZ12, EED and EZH1/2 and is responsible for catalysing both di-methylation and tri-methylation of Histone H3 at lysine 27 (H3K27me2/3).
Endometrial stromal sarcoma--the new genetic paradigm.
Nucci et al., Edmonton, Canada. In Histopathology, Jul 2015
Low-grade ESSs frequently contain chromosomal rearrangements that result in JAZF1-SUZ12 fusion or equivalent genetic fusions.
Role of PRC2-associated factors in stem cells and disease.
Di Croce et al., Barcelona, Spain. In Febs J, May 2015
The core canonical complex PRC2, which contains the EZH1/2, SUZ12 and EED proteins, may be extended and functionally manipulated through interactions with several other proteins.
MiR-449a suppresses cell invasion by inhibiting MAP2K1 in non-small cell lung cancer.
Zhou et al., Tianjin, China. In Am J Cancer Res, 2014
Furthermore, the histone methylation mediated the decreased expression of miR-449a through SUZ12.
The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington's Disease.
Weng et al., Boston, United States. In Plos One, 2014
Six transcription factors and chromatin remodelers are differentially enriched in HD H3K4me3 distal peaks, including EZH2 and SUZ12, two core subunits of the polycomb repressive complex 2 (PRC2).
Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors.
Bettegowda et al., Baltimore, United States. In Nat Genet, 2014
Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation.
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors.
Chi et al., New York City, United States. In Nat Genet, 2014
Using comprehensive genomic approaches, we identified loss-of-function somatic alterations of the Polycomb repressive complex 2 (PRC2) components (EED or SUZ12) in 92% of sporadic, 70% of NF1-associated and 90% of radiotherapy-associated MPNSTs.
Endometrial stromal tumors: the new WHO classification.
Longacre et al., Stanford, United States. In Adv Anat Pathol, 2014
Specifically, the JAZF1-SUZ12 (formerly JAZF1-JJAZ1) fusion identifies a large proportion of ESN and LG-ESSs, whereas the YWHAE-FAM22 translocation identifies HG-ESSs.
PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies.
Cichowski et al., Boston, United States. In Nature, 2014
Here we provide genomic, cellular, and mouse modelling data demonstrating that the polycomb group gene SUZ12 functions as tumour suppressor in PNS tumours, high-grade gliomas and melanomas by cooperating with mutations in NF1.
A family of pleiotropically acting microRNAs in cancer progression, miR-200: potential cancer therapeutic targets.
Li et al., Shantou, China. In Curr Pharm Des, 2013
Importantly, miR-200s also modulate the self-renewal ability of cancer stem cells by targeting BMI1 and SUZ12.
Braveheart, a long noncoding RNA required for cardiovascular lineage commitment.
Boyer et al., Cambridge, United States. In Cell, 2013
We also show that Bvht interacts with SUZ12, a component of polycomb-repressive complex 2 (PRC2), during cardiomyocyte differentiation, suggesting that Bvht mediates epigenetic regulation of cardiac commitment.
Genetic defects in PRC2 components other than EZH2 are not common in myeloid malignancies.
Jansen et al., In Blood, 2012
Genetic defects in PRC2 components other than EZH2 are not common in myeloid malignancies.
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia.
Aifantis et al., New York City, United States. In Nat Med, 2012
studies suggest a tumor suppressor role for PRC2 in human leukemia and suggest a hitherto unrecognized dynamic interplay between oncogenic NOTCH1 and PRC2 function
Polycomb repressive complex 2 targets murine cytomegalovirus chromatin for modification and associates with viral replication centers.
Kulesza et al., Aurora, United States. In Plos One, 2011
Data indicate that binding of EZH2, SUZ12 and EED, the 3 subunits of Plybomb repressive complex 2 (PRC2), is required for PRC2 full activity, and late during viral infection, a significant increase in PRC2 protein association with chromatin.
Proteins ZNF198 and SUZ12 are down-regulated in hepatitis B virus (HBV) X protein-mediated hepatocyte transformation and in HBV replication.
Andrisani et al., West Lafayette, United States. In Hepatology, 2011
We propose Plk1 activity down-regulates ZNF198 and SUZ12, thereby enhancing both HBV replication and pX-mediated oncogenic transformation.
RARγ is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells.
Gudas et al., New York City, United States. In J Cell Physiol, 2011
Data show that RARgamma is required for deposition of H2A.Z and Suz12 at RA target genes, and that in embryonic stem cells both RARgamma and Suz12 exist in a multi-protein complex in the absence of ligand.
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