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Suppressor of variegation 3-9 homolog 2

Suv39h2, Suppressor of variegation 3-9 homolog 2
Top mentioned proteins: Histone, SUV39H1, G9a, EZH2, SETDB1
Papers on Suv39h2
Dynamic changes of histone H3 lysine 9 following trimethylation in bovine oocytes and pre-implantation embryos.
Li et al., Changchun, China. In Biotechnol Lett, Dec 2015
OBJECTIVES: We have examined dynamic changes of histone H3 lysine 9 following trimethylation (H3K9me3), the mRNA expression levels of SUV39H1 and SUV39H2 in bovine oocytes and the role in the development of in vitro fertilization (IVF) pre-implantation embryos.
Histone acetylation and methylation significantly change with severity of atherosclerosis in human carotid plaques.
Pelisek et al., München, Germany. In Cardiovasc Pathol, Dec 2015
The expression of histone acetyltransferases (GNAT group: GCN5L, P300/CBP group: P300, MYST group: MYST1 and MYST2) and histone methyltransferases (H3K4: MLL2/4, SET7/9, and hSET1A; H3K9: SUV39H1, SUV39H2, ESET/SETDB1, and EHMT1; H3K27: EZH2 and G9a) was analyzed by SYBR-green-based real-time polymerase chain reaction.
Targeting Suppressor of Variegation 3-9 Homologue 2 (SUV39H2) in Acute Lymphoblastic Leukemia (ALL).
Alachkar et al., Chicago, United States. In Transl Oncol, Oct 2015
Suppressor of variegation 3-9 homologue 2 (SUV39H2), also known as KMT1B, is a SET-domain-containing histone methyltransferase that is upregulated in solid cancers, but its expression is hardly detectable in normal tissues.
Effect of intra-uterine growth restriction on long-term fertility in boars.
Dong et al., In Reprod Fertil Dev, Sep 2015
Expression of DNA methyltransferase (Dnmt) genes Dnmt1, Dnmt3a, histone-lysine N-methyltransferase (Suv39h2), and lysine (K)-specific demethylase Kdm4a was upregulated in testes from IUGR boars.
H3K9 Trimethylation Silences Fas Expression To Confer Colon Carcinoma Immune Escape and 5-Fluorouracil Chemoresistance.
Liu et al., Hangzhou, China. In J Immunol, Sep 2015
We discovered that verticillin A is a selective inhibitor of histone methyltransferases SUV39H1, SUV39H2, and G9a/GLP that exhibit redundant functions in H3K9 trimethylation and FAS transcriptional silencing.
SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells.
Hamamoto et al., Chicago, United States. In Oncotarget, Aug 2015
Here, we demonstrate that the histone lysine methyltransferase SUV39H2 trimethylated LSD1 on lysine 322.
Vitamin A induces inhibitory histone methylation modifications and down-regulates trained immunity in human monocytes.
Netea et al., Nijmegen, Netherlands. In J Leukoc Biol, Jul 2015
ATRA inhibited cytokine responses upon restimulation of monocytes, and this effect was exerted through increased expression of SUV39H2, a histone methyltransferase that induces the inhibitory mark H3K9me3.
H3K9MTase G9a is essential for the differentiation and growth of tenocytes in vitro.
Nifuji et al., Yokohama, Japan. In Histochem Cell Biol, Jul 2015
In primary mouse tenocytes, six H3K9 methyltransferase (H3K9MTase) genes, i.e., G9a, G9a-like protein (GLP), PR domain zinc finger protein 2 (PRDM2), SUV39H1, SUV39H2, and SETDB1/ESET were all expressed, with increased mRNA levels observed during tenocyte differentiation.
MiR-101 reverses the hypomethylation of the LMO3 promoter in glioma cells.
Wu et al., Changsha, China. In Oncotarget, May 2015
It was determined that miR-101 decreases the occupancy of H3K27me3 by inhibiting EZH2, DNMT3A and EED and decreases the H3K9me3 occupancy on the LMO3 promoter via SUV39H1, SUV39H2, G9a and PHF8.
Alternative splicing regulates the expression of G9A and SUV39H2 methyltransferases, and dramatically changes SUV39H2 functions.
Batsché et al., Paris, France. In Nucleic Acids Res, Mar 2015
Here, we have investigated how alternative splicing affects the function of two human histone methyltransferases (HMTase): G9A and SUV39H2.
DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells.
Tanaka et al., Tokyo, Japan. In Plos One, 2014
The expression levels of Suv39h1 and Suv39h2, histone methyltransferases for H3K9me3, were inversely correlated with Twist1 expression, and knockdown of Suv39h1 or Suv39h2 induced Twist1 expression.
Altered telomere homeostasis and resistance to skin carcinogenesis in Suv39h1 transgenic mice.
Schoeftner et al., Trieste, Italy. In Cell Cycle, 2014
The Suv39h1 and Suv39h2 H3K9 histone methyltransferases (HMTs) have a conserved role in the formation of constitutive heterochromatin and gene silencing.
Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair.
Hamamoto et al., Chicago, United States. In Nat Commun, 2013
Here we find that the histone methyltransferase SUV39H2 methylates histone H2AX on lysine 134.
Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes.
FinnDiane Study Group et al., Helsinki, Finland. In Diabetes, 2011
genetic association studies in a Finnish population with type I diabetes: The minor T allele of exonic SNP rs17353856 in SUV39H2 is associated with diabetic retinopathy (in a larger meta-analysis); thus an genetic variation may be protective.
Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia.
Mendelson et al., Dallas, United States. In Mol Cell Biol, 2011
findings suggest that Suv39H1 and Suv39H2 are key hypoxia-induced methyltransferases; their decline in fetal lung during late gestation is critical for epigenetic changes resulting in the developmental induction of SP-A
PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.
Peters et al., Basel, Switzerland. In Nat Genet, 2008
In Suv39h2 maternally deficient zygotes, PRC1 also associates with maternal heterochromatin lacking H3K9me3, thereby revealing hierarchy between repressive pathways.
Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes.
Chen et al., Shanghai, China. In Plos One, 2007
The SUV39H2 gene is found in tetrapods (e.g., human, mouse and frog) but not in zebrafish, suggesting that this gene is generated by a tetrapod lineage-specific gene duplication event.
Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer.
Lee et al., South Korea. In Carcinogenesis, 2006
a novel SUV39H2 polymorphism may have a role in lung cancer susceptibility for smokers
Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases.
Blasco et al., Madrid, Spain. In Nat Genet, 2004
Taken together, the results indicate epigenetic regulation of telomere length in mammals by Suv39h1 and Suv39h2.
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