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Surfeit gene 6

This gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. The gene demonstrates features of a housekeeping gene, being ubiquitously expressed, and the encoded protein has been localized to the nucleolus. The protein includes motifs found in both the mouse and fish orthologs, which suggests a putative function as a nucleolar-matrix protein with nucleic acid-binding properties, based on characteristics determined in mouse. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: B23, CAN, GST, OUT, glycosyltransferase
Papers on Surf-6
[Identification of the protein partners of the human nucleolar protein SURF6 in HeLa cells by GST pull-down assay].
Zatsepina et al., In Bioorg Khim, 2014
The eukaryotic proteins comprising the SURF6 protein family are evolutionary conservative and housekeeping proteins however, functional roles of human SURF6 have not been studied so far.
Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women.
Wei et al., Tianjin, China. In Nat Commun, 2013
(rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
Development of novel mouse hybridomas producing monoclonal antibodies specific to human and mouse nucleolar protein SURF-6.
Zatsepina et al., Moscow, Russia. In Hybridoma (larchmt), 2012
SURF-6 is an evolutionarily conserved nucleolar protein that is important for cell viability; however, its function in mammals still remains uncertain.
Molecular characterization of the human ABO blood group orthologus system in pigs.
Park et al., Seoul, South Korea. In Anim Genet, 2011
The analysis showed that the 0 allele has a large deletion between exon 7 of the A0 blood group gene and the neighbouring SURF6.
[Cloning, expression, and isolation from Escherichia coli of human protein SURF-6 translationally fused to glutathione S-transferase].
Polzikov et al., In Prikl Biokhim Mikrobiol, 2011
cDNA of human gene Surf-6 (hSutf-6) was amplified and cloned into vector pGEX-2T for the expression in the bacterial system of protein hSURF-6 translationally fused to glutathione S-transferase.
[The levels of key nucleolar proteins in the lymphoid cells of healthy individuals and patients with lymphoproliferative diseases].
Zatsepina et al., In Klin Lab Diagn, 2010
Immunocytochemical staining with specific antibodies was used to study the expression of three nucleolar proteins (fibrillarin, B23/nucleofozmin, and SURF6), which were involved in pRNA maturation, in the lymphoid cells of healthy individuals and patients with lymphoproliferative diseases and to compare it with the expression of the known proliferation marker Ki-67 protein.
[Overexpression of the nucleolar protein SURF-6 in mouse fibroblasts NIH/3T3 leads to stabilisation of intragenic transcribed spacers of the pre-rRNA].
Zatsepina et al., In Bioorg Khim, 2010
The plasmid pUHrT62-1 encodes a tetracycline-dependant trans-activator, the protein rtTA, the plasmid pBI-SURF6--the genes of EGFP (enhanced green fluorescent protein) and of mouse SURF-6 which expression was controlled by the rtTA-responsive bi-directorial promoter.
Early expression of nucleolar SURF-6 protein in mouse spleen lymphocytes activated for proliferation in vitro.
Zatsepina et al., Moscow, Russia. In Bull Exp Biol Med, 2009
The observations suggest that nucleolar protein SURF-6 can act as a marker of early T lymphocyte activation for proliferation and that it could participate in cell cycle regulation in mammals.
The nucleolar protein SURF-6 is essential for viability in mouse NIH/3T3 cells.
Zatsepina et al., Moscow, Russia. In Mol Biol Rep, 2007
Expression of SURF-6 is essential for mammalian cell viability and cell cycle progression.
Implication of nucleolar protein SURF6 in ribosome biogenesis and preimplantation mouse development.
Schultz et al., Philadelphia, United States. In Biol Reprod, 2006
Surf6 is essential for mouse preimplantation development, presumably by regulating ribosome biogenesis.
Identification of an evolutionary conserved SURF-6 domain in a family of nucleolar proteins extending from human to yeast.
Magoulas et al., Moscow, Russia. In Biochem Biophys Res Commun, 2005
The mammalian SURF-6 protein is localized in the nucleolus, yet its function remains elusive in the recently characterized nucleolar proteome.
The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts.
Pietropaolo et al., Napoli, Italy. In Gene, 2002
The nucleotide sequence of the genomic region flanking the 3'-end of the Hu-Surf5 gene revealed the presence of a processed pseudogene of human ribosomal protein L21 followed by Hu-Surf6 gene.
Identification and characterization of proteins that interact with Drosophila melanogaster protein kinase CK2.
Bidwai et al., Morgantown, United States. In Mol Cell Biochem, 2001
Most notable among these are Surf6, a nucleolar protein involved in RNA processing, and Spalt, a homeotic protein.
Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus.
Fried et al., London, United Kingdom. In Gene, 2000
The human Surfeit locus contains at least six tightly clustered genes (Surf-1 to Surf-6) of which five (Surf-1 to Surf-5) have been characterised and found not to share any sequence homology.
The human Surfeit locus.
Fried et al., London, United Kingdom. In Genomics, 1998
The organization of the human Surfeit locus containing the six sequence-unrelated housekeeping genes Surf-1 to Surf-6 (HGMW-approved symbols SURF1-SURF6) has been determined.
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