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Superoxide dismutase 2, mitochondrial

superoxide dismutase, MnSOD
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SOD, catalase, ACID, CAN, Ros
Papers using superoxide dismutase antibodies
Overexpression of aldehyde dehydrogenase 1A1 reduces oxidation-induced toxicity in SH-SY5Y neuroblastoma cells
Bohmann Dirk et al., In Disease Models & Mechanisms, 2009
... Attenuation of 6-hydroxydopamine-induced dopaminergic nigrostriatal lesions in superoxide dismutase transgenic mice ...
Soluble misfolded subfractions of mutant superoxide dismutase-1s are enriched in spinal cords throughout life in murine ALS models
Borchelt David R. et al., In Human Molecular Genetics, 2006
... Disulphide-reduced superoxide dismutase-1 in CNS of transgenic amyotrophic lateral sclerosis models ...
A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation
Fischbeck Kenneth H. et al., In Human Molecular Genetics, 2005
... Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice ...
Comprehensive glyco-proteomic analysis of human alpha1-antitrypsin and its charge isoforms
Sang Qing-Xiang Amy et al., In Journal of Cancer, 2005
... anti-human rabbit antibodies against ER-α MC-20 (MW 66 kDa), calmodulin FL-149 (MW 17 kDa), and superoxide dismutase FL-222 (MW 25 kDa) were purchased from Santa Cruz Biotechnology, Inc ...
p53 Translocation to Mitochondria Precedes Its Nuclear Translocation and Targets Mitochondrial Oxidative Defense Protein-Manganese Superoxide Dismutase
St Clair Daret K. et al., In Oncogene, 2004
... inhibitor set III from Calbiochem (La Jolla, CA), dithiothreitol from BioRad (Carlsbad, CA), rabbit poly-clonal anti-MnSOD from Upstate Technology (Lake Placid, NY), Protein A/G agarose from Santa Cruz Biotechnology (Santa Cruz, CA), rabbit ...
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Papers on superoxide dismutase
Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges.
Mattson et al., Baltimore, United States. In Cell Metab, Feb 2016
SIRT3 deficiency results in hyperacetylation of several mitochondrial proteins, including superoxide dismutase 2 and cyclophilin D. Running wheel exercise increases the expression of Sirt3 in hippocampal neurons, which is mediated by excitatory glutamatergic neurotransmission and is essential for mitochondrial protein acetylation homeostasis and the neuroprotective effects of running.
Activity of antioxidant enzymes in response to atmospheric pressure induced physiological stress in deep-sea hydrothermal vent mussel Bathymodiolus azoricus.
Bettencourt et al., Portugal. In Mar Environ Res, Feb 2016
The enzymatic activities of superoxide dismutase (SOD), catalase (CAT), and iron storage proteins in addition to electrophoretic profiles were examined in vent mussel gills and digestive gland.
Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes.
Fukushima et al., Obihiro, Japan. In World J Gastroenterol, Feb 2016
Antioxidant phytochemicals, such as polyphenols, regulate the expression of ALD-associated proteins and peptides, namely, catalase, superoxide dismutase, glutathione, glutathione peroxidase, and glutathione reductase.
Strong Associations Exist among Oxidative Stress and Antioxidant Biomarkers in the Circulating, Cellular and Urinary Anatomical Compartments in Guatemalan Children from the Western Highlands.
Gil et al., Guatemala City, Guatemala. In Plos One, Dec 2015
The urinary oxidative stress biomarkers studied were F2-isoprostanes and 8-hydroxy-deoxy-guanosine. Red cell enzyme activities measured were: catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase.
ALA Pretreatment Improves Waterlogging Tolerance of Fig Plants.
Wang et al., Nanjing, China. In Plos One, Dec 2015
Moreover, ALA pretreatment significantly increased activities of leaf superoxide dismutase (SOD) and peroxidase (POD), root vigor, and activities of root alcohol dehydrogenase (ADH), and lactate dehydrogenase (LDH), indicating ALA also significantly improves antioxidant ability and root function of fig plants under waterlogging stress.
Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage.
Bergthaler et al., Vienna, Austria. In Immunity, Dec 2015
Using a mouse model of viral hepatitis, we identified virus-induced early transcriptional changes in the redox pathways in the liver, including downregulation of superoxide dismutase 1 (Sod1).
Effects of tempol on altered metabolism and renal vascular responsiveness in fructose-fed rats.
Johns et al., Cork, Ireland. In Appl Physiol Nutr Metab, Dec 2015
UNASSIGNED: This study investigated the effect of tempol (a superoxide dismutase mimetic) on renal vasoconstrictor responses to angiotensin II (Ang II) and adrenergic agonists in fructose-fed Sprague-Dawley rats (a model of metabolic syndrome).
Ascorbic acid supplementation does not alter oxidative stress markers in healthy volunteers engaged in a supervised exercise program.
Anthony et al., Chiang Mai, Thailand. In Appl Physiol Nutr Metab, Nov 2015
After 3 months of exercise, there was no significant change in blood glucose, lipid profile, MDA, TAS, superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase activities amongst groups.
[Recent advances in the study of Nrf2 and inflammatory respiratory diseases].
Hou et al., In Yao Xue Xue Bao, Sep 2015
As a result, Nrf2 enhances the expression of glutathione and antioxidants such as superoxide dismutase and glutathione S-transferase, and subsequently scavenging free radicals.
Nothing Boring About Boron.
Pizzorno, Seattle, United States. In Integr Med (encinitas), Aug 2015
As the current article shows, boron has been proven to be an important trace mineral because it (1) is essential for the growth and maintenance of bone; (2) greatly improves wound healing; (3) beneficially impacts the body's use of estrogen, testosterone, and vitamin D; (4) boosts magnesium absorption; (5) reduces levels of inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor α (TNF-α); (6) raises levels of antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase; (7) protects against pesticide-induced oxidative stress and heavy-metal toxicity; (8) improves the brains electrical activity, cognitive performance, and short-term memory for elders; (9) influences the formation and activity of key biomolecules, such as S-adenosyl methionine (SAM-e) and nicotinamide adenine dinucleotide (NAD(+)); (10) has demonstrated preventive and therapeutic effects in a number of cancers, such as prostate, cervical, and lung cancers, and multiple and non-Hodgkin's lymphoma; and (11) may help ameliorate the adverse effects of traditional chemotherapeutic agents.
Copper transport and trafficking at the host-bacterial pathogen interface.
Giedroc et al., Bloomington, United States. In Acc Chem Res, 2015
Recent highlights of copper chemistry at the host-microbial pathogen interface include the first high resolution structures and functional characterization of a Cu(I)-effluxing P1B-ATPase, a new class of bacterial copper chaperone, a fungal Cu-only superoxide dismutase SOD5, and the discovery of a small molecule Cu-bound SOD mimetic.
Cholesterol and metal ions in Alzheimer's disease.
Lim et al., Ann Arbor, United States. In Chem Soc Rev, 2014
For example, (a) cholesterol has been shown to be misregulated in AD-afflicted brains, and the aberrant activity of proteins (particularly, apolipoprotein E (ApoE) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)) has been linked to cholesterol-related AD exacerbation; (b) dyshomeostasis of metal ions associated with misfolded proteins (i.e., amyloid-β (Aβ) aggregates) found in the brains of AD patients is shown to promote oxidative stress leading to the malfunction of multiple proteins, including cytochrome c oxidase (CcO), and Cu/Zn superoxide dismutase (SOD1); (c) metal ion misregulation has also been observed to disrupt the activity of proteins (e.g., HMGR, low-density lipoproteins (LDL)), required for cholesterol production and regulation.
Insight into the structure and mechanism of nickel-containing superoxide dismutase derived from peptide-based mimics.
Shearer, Reno, United States. In Acc Chem Res, 2014
Nickel superoxide dismutase (NiSOD) is a nickel-containing metalloenzyme that catalyzes the disproportionation of superoxide through a ping-pong mechanism that relies on accessing reduced Ni(II) and oxidized Ni(III) oxidation states.
Role of Oxidative Stress in HIV-1-Associated Neurocognitive Disorder and Protection by Gene Delivery of Antioxidant Enzymes.
Strayer et al., Philadelphia, United States. In Antioxidants (basel), 2013
We used SV40 vectors for gene delivery of antioxidant enzymes, Cu/Zn superoxide dismutase (SOD1), or glutathione peroxidase (GPx1) into the rat caudate putamen (CP).
Antioxidant Defenses in Plants with Attention to Prunus and Citrus spp.
Racchi, Florence, Italy. In Antioxidants (basel), 2012
Biochemical and molecular features of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxidase (APX) are discussed because they play crucial roles in scavenging ROS in the different cell compartments and in response to stress conditions.
27-hydroxycholesterol and the expression of three estrogen-sensitive proteins in MCF7 cells.
Sierralta et al., Santiago, Chile. In Oncol Rep, 2012
Exposure to a major circulating cholesterol metabolite initiates a phenotypic change to a mesenchymal cell type in MCF7 cells with increased expression of MnSOD, FOXM1 and estrogen receptor beta.
Manganese superoxide dismutase regulates a metabolic switch during the mammalian cell cycle.
Goswami et al., Iowa City, United States. In Cancer Res, 2012
MnSOD regulates a "metabolic switch" during progression from quiescent through the proliferative cycle.
Metallation state of human manganese superoxide dismutase expressed in Saccharomyces cerevisiae.
Whittaker et al., Beaverton, United States. In Arch Biochem Biophys, 2012
metallation state of human manganese superoxide dismutase expressed in Saccharomyces cerevisiae
Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling.
Zhou et al., Guangzhou, China. In Free Radic Biol Med, 2012
High SOD2 is associated with migration and invasion of tongue squamous cell carcinoma.
Acquisition of resistance of pancreatic cancer cells to 2-methoxyestradiol is associated with the upregulation of manganese superoxide dismutase.
Du et al., Fayetteville, United States. In Mol Cancer Res, 2012
Data suggest that upregulation of manganese superoxide dismutase (SOD2) expression is an important mechanism pancreatic cancer cells acquire resistance to reactive oxygen species-inducing, anticancer drugs, and potentially also to ionizing radiation.
More papers using superoxide dismutase antibodies
Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation
Fisher Elizabeth M. C. et al., In Disease Models & Mechanisms, 1996
... Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice ...
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